生物文献研读笔记 生物医学文献追踪与解读
月报 CNS 主刊

Nature_Science_Cell主刊文献月报_2026-09

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Nature、Science、Cell 生物医学与 AI 文献月报

统计月份： 2026-09检索日期： 2026-10-06 覆盖时间： 2026/09/01 至 2026/09/30检索期刊： Nature、Science、Cell（仅限主刊）检索来源： PubMed E-utilities（ESearch + EFetch）、期刊官方 DOI 页面、PubMed Central 纳入标准： Nature/Science/Cell 主刊发表的研究论文；主题涉及生物学、医学、生命科学、生物技术、神经科学、免疫学、肿瘤学、发育生物学、细胞生物学、遗传学与基因组学、蛋白质科学/结构生物学、微生物/病毒/感染、药物研发/诊断/治疗，或人工智能与生命科学/医学/药物研发的交叉研究；排除新闻、社论、评论、勘误等非研究性文章。 排除标准： 非主刊（子刊）文章；与生物医学/AI 无关的文章；新闻、社论、评论、书评、人物访谈、政策评论；信息无法核验的文章；DOI/摘要/官方链接缺失的文章。

本月结果概览

  • PubMed 检索命中 PMIDs：361 条
  • 成功获取元数据：361 篇
  • 研究性文章：242 篇
  • Nature/Science/Cell 主刊研究性文章：207 篇
  • 排除非研究性文章：119 篇
  • 排除非主刊文章：35 篇
  • 本报告详细解读精选文献：20 篇

一、本月高价值文献总表

序号 题目 期刊 发表日期 研究领域 文章类型 PMID DOI OA 状态 推荐等级
1 GPCR antagonism via rewiring of receptor trafficking and degradation. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42816619 10.1038/s41586-026-11088-0 可能开放获取（PMC ID: PMC13632652） A
2 Dynamic protrusions mediate crawling motility in Asgard archaea. Nature 未提供 细胞生物学、药物研发、人工智能 Research Article 42816618 10.1038/s41586-026-11063-9 非 OA / 需订阅访问 A
3 γδ T cell receptor dependencies define a unique immunosurveillance modality. Nature 未提供 免疫学、遗传学与基因组学、人工智能 Research Article 42816614 10.1038/s41586-026-11076-4 非 OA / 需订阅访问 A
4 Prion-like transmission of human tau strains in the mouse brain. Nature 未提供 神经科学、遗传学与基因组学、结构生物学 Research Article 42816607 10.1038/s41586-026-11061-x 非 OA / 需订阅访问 A
5 Function-preserving watermarking of AI-generated proteins. Nature 未提供 遗传学与基因组学、结构生物学、药物研发 Research Article 42816606 10.1038/s41586-026-10965-y 非 OA / 需订阅访问 A
6 Written in development and lost in ageing: the grammar of cellular identity. Nature 未提供 发育生物学、细胞生物学、遗传学与基因组学 Review 42816559 10.1038/s41586-026-10955-0 非 OA / 需订阅访问 A
7 Scalable decision-making for games of imperfect information. Nature 未提供 遗传学与基因组学、人工智能 Research Article 42816558 10.1038/s41586-026-11036-y 可能开放获取（PMC ID: PMC13626944） A
8 Single-cell atlas of transcriptomic vulnerability across brain disorders. Nature 未提供 神经科学、免疫学、细胞生物学 Research Article 42778699 10.1038/s41586-025-09573-z 可能开放获取（PMC ID: PMC13600946） A
9 TRAM promotes Toll-like-receptor-free myddosome signal transduction. Nature 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42778610 10.1038/s41586-026-11052-y 非 OA / 需订阅访问 A
10 A design approach for bitopic kinase inhibitors. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42778601 10.1038/s41586-026-11056-8 非 OA / 需订阅访问 A
11 Lsp2 links early-life diet to adult translation and lifespan in Drosophila. Nature 未提供 发育生物学、遗传学与基因组学、蛋白质科学 Research Article 42778590 10.1038/s41586-026-11031-3 非 OA / 需订阅访问 A
12 Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes. Nature 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42778177 10.1038/s41586-026-11169-0 非 OA / 需订阅访问 A
13 Chemist-aligned retrosynthesis by ensembling diverse inductive bias models. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42767646 10.1038/s41586-026-11160-9 非 OA / 需订阅访问 A
14 A thermodynamically favoured molecular computer. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42749917 10.1038/s41586-026-10996-5 可能开放获取（PMC ID: PMC13581610） A
15 Rapid patient-specific neural networks for X-ray to volume registration. Nature 未提供 神经科学、遗传学与基因组学、人工智能 Research Article 42749809 10.1038/s41586-026-11045-x 非 OA / 需订阅访问 A
16 Reimagining research papers as interactive and reliable AI agents. Nature 未提供 遗传学与基因组学、人工智能、生物技术 Research Article 42749808 10.1038/s41586-026-11044-y 非 OA / 需订阅访问 A
17 Identification of broadly tumour-reactive γδ TCRs from multiple myeloma. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42749802 10.1038/s41586-026-11055-9 非 OA / 需订阅访问 A
18 Mutational constraints on RSV F and its neutralization by antibodies. Nature 未提供 免疫学、发育生物学、遗传学与基因组学 Research Article 42749798 10.1038/s41586-026-11030-4 可能开放获取（PMC ID: PMC13587686） A
19 Quality control of glycogen through direct ubiquitylation by RNF213. Nature 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42744304 10.1038/s41586-026-11139-6 非 OA / 需订阅访问 A
20 Encoded and non-genetic protein variants expand human functional proteome. Nature 未提供 肿瘤学、遗传学与基因组学、蛋白质科学 Research Article 42742175 10.1038/s41586-026-11124-z 非 OA / 需订阅访问 A
21 Phosphine-mediated azine C-H couplings with water and ammonia. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42742168 10.1038/s41586-026-10991-w 可能开放获取（PMC ID: PMC13600945） A
22 An operational perturbation proteomics-based virtual cell model. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42717098 10.1038/s41586-026-11001-9 非 OA / 需订阅访问 A
23 Imaging cellular activity across all organs reveals body-wide circuits. Nature 未提供 神经科学、免疫学、细胞生物学 Research Article 42717095 10.1038/s41586-026-10979-6 非 OA / 需订阅访问 A
24 TRI-611, a selective, brain-penetrant molecular glue degrader of ALK. Nature 未提供 神经科学、肿瘤学、遗传学与基因组学 Research Article 42717093 10.1038/s41586-026-10998-3 非 OA / 需订阅访问 A
25 Proximity-guided graph learning reveals tumour-associated proximity antigens. Nature 未提供 发育生物学、细胞生物学、遗传学与基因组学 Research Article 42717092 10.1038/s41586-026-11003-7 非 OA / 需订阅访问 A
26 Predicting genome-wide functional constraints with GPN-Star. Nature 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42717086 10.1038/s41586-026-11005-5 非 OA / 需订阅访问 A
27 Breaking timescales with generative sampling of conformational transitions. Nature 未提供 细胞生物学、遗传学与基因组学、结构生物学 Research Article 42717085 10.1038/s41586-026-11025-1 非 OA / 需订阅访问 A
28 TM184C is a GPCR-like regulator of intercellular exchange and autophagy. Nature 未提供 细胞生物学、人工智能、蛋白质科学 Research Article 42717083 10.1038/s41586-026-10993-8 可能开放获取（PMC ID: PMC13581589） A
29 Operational tropical cyclone forecasting with AI. Nature 未提供 发育生物学、遗传学与基因组学、人工智能 Research Article 42717078 10.1038/s41586-026-10953-2 可能开放获取（PMC ID: PMC13581599） A
30 Explainable deep learning improves human mental models of self-driving cars. Nature 未提供 神经科学、人工智能 Research Article 42687026 10.1038/s41586-026-10950-5 可能开放获取（PMC ID: PMC13538056） A
31 Creating bottom-up RNA transfer vehicles from synthetic protein assemblies. Nature 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42686908 10.1038/s41586-026-10952-3 非 OA / 需订阅访问 A
32 3D epigenome of glial cell types in developing human cortex. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42686907 10.1038/s41586-026-10987-6 非 OA / 需订阅访问 A
33 Late-life semaglutide treatment slows ageing and extends lifespan in female mice. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42686906 10.1038/s41586-026-10940-7 可能开放获取（PMC ID: PMC13558073） A
34 Probing far-from-equilibrium dynamics of electrical double layers. Nature 未提供 药物研发、人工智能 Research Article 42686904 10.1038/s41586-026-10986-7 非 OA / 需订阅访问 A
35 Connectome analysis of a cerebellum-like circuit for sensory prediction. Nature 未提供 神经科学、药物研发、人工智能 Research Article 42686902 10.1038/s41586-026-10690-6 非 OA / 需订阅访问 A
36 Rewiring the ribosome to translate proteins encoded in its own RNA. Nature 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42686901 10.1038/s41586-026-10962-1 非 OA / 需订阅访问 A
37 Human brain organoids record the passage of time over multiple years. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42618795 10.1038/s41586-026-10877-x 可能开放获取（PMC ID: PMC13581598） A
38 The HydroGym reinforcement learning platform for fluid dynamics. Nature 未提供 遗传学与基因组学、结构生物学、人工智能 Research Article 42618782 10.1038/s41586-026-10917-6 可能开放获取（PMC ID: PMC13558066） A
39 Luminescent-reaction-enabled super-resolution imaging. Nature 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42587155 10.1038/s41586-026-10889-7 可能开放获取（PMC ID: PMC13538040） A
40 Rb-driven transcription limits its tumour-suppressive effects in breast cancer. Nature 未提供 肿瘤学、细胞生物学、遗传学与基因组学 Research Article 42587147 10.1038/s41586-026-10886-w 可能开放获取（PMC ID: PMC13558077） A
41 An expanded codebook of human transcription factor DNA-binding specificity. Nature 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42557334 10.1038/s41586-026-10798-9 可能开放获取（PMC ID: PMC13538051） A
42 An ancient mitochondrial program tunes translation to haem availability. Nature 未提供 发育生物学、细胞生物学、药物研发 Research Article 42557333 10.1038/s41586-026-10885-x 可能开放获取（PMC ID: PMC13600944） A
43 The Virtual Tissues foundation model resolves spatial proteomics across scales. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42557331 10.1038/s41586-026-10884-y 可能开放获取（PMC ID: PMC13581600） A
44 ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer. Nature 未提供 肿瘤学、发育生物学、细胞生物学 Research Article 42557330 10.1038/s41586-026-10890-0 可能开放获取（PMC ID: PMC13600930） A
45 DCAF11-dependent molecular glue degrader activated by glutathionylation. Nature 未提供 药物研发、蛋白质科学 Research Article 42557329 10.1038/s41586-026-10873-1 可能开放获取（PMC ID: PMC13600927） A
46 Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours. Nature 未提供 神经科学、遗传学与基因组学、药物研发 Research Article 42557328 10.1038/s41586-026-10874-0 可能开放获取（PMC ID: PMC13558064） A
47 Antigen presentation by CD40 + MHC-II + astrocytes promotes CNS autoimmunity. Nature 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42557325 10.1038/s41586-026-10860-6 非 OA / 需订阅访问 A
48 Uncovering the mechanism of female restitution in sugarcane hybrids. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42557324 10.1038/s41586-026-10863-3 非 OA / 需订阅访问 A
49 A tumour-derived organoid biobank maps cancer gene dependencies. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42557320 10.1038/s41586-026-10830-y 可能开放获取（PMC ID: PMC13581617） A
50 FNIP1 variants are associated with favourable metabolism in 1 million humans. Nature 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42557317 10.1038/s41586-026-10864-2 可能开放获取（PMC ID: PMC13581615） A
51 A compendium of next-generation patient-derived models for diverse cancers. Nature 未提供 肿瘤学、发育生物学、遗传学与基因组学 Research Article 42557316 10.1038/s41586-026-10806-y 可能开放获取（PMC ID: PMC13581597） A
52 Diverse bacterial pattern recognition receptors sense the core phage proteome. Nature 未提供 神经科学、免疫学、遗传学与基因组学 Research Article 42527607 10.1038/s41586-026-10852-6 可能开放获取（PMC ID: PMC13581612） A
53 Miniaturizing and modifying natural proteins with Raygun. Nature 未提供 遗传学与基因组学、人工智能、蛋白质科学 Research Article 42527603 10.1038/s41586-026-10842-8 可能开放获取（PMC ID: PMC13600932） A
54 Subnuclear genome compartmentalization controls bivalent chromatin activity. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42486990 10.1038/s41586-026-10832-w 可能开放获取（PMC ID: PMC13558055） A
55 AI-redesigned starting points and outcomes enhance protein evolution. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42486980 10.1038/s41586-026-10820-0 可能开放获取（PMC ID: PMC13477572） A
56 An encyclopedia of human enhancer-gene regulatory interactions. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42457959 10.1038/s41586-026-10781-4 可能开放获取（PMC ID: PMC13471189） A
57 Modular in vivo antibody-ADC click to reverse drug resistance in tumours. Nature 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42457957 10.1038/s41586-026-10789-w 可能开放获取（PMC ID: PMC13538031） A
58 Aneuploidy selects for the acquisition of driver genes in breast cancer. Nature 未提供 肿瘤学、细胞生物学、遗传学与基因组学 Research Article 42420452 10.1038/s41586-026-10752-9 非 OA / 需订阅访问 A
59 An intrinsic cytoskeletal oscillator establishes neuronal polarity. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42420447 10.1038/s41586-026-10755-6 可能开放获取（PMC ID: PMC13538037） A
60 Non-genotoxic transplantation and in vivo selection through epitope editing. Nature 未提供 免疫学、肿瘤学、发育生物学 Research Article 42420446 10.1038/s41586-026-10737-8 可能开放获取（PMC ID: PMC13538065） A
61 Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42815464 10.1016/j.cell.2026.09.011 可能开放获取（PMC ID: PMC13629491） A
62 Spatial evolution of a cachexia-promoting microenvironment in pancreatic cancer. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42810340 10.1016/j.cell.2026.09.012 非 OA / 需订阅访问 A
63 Cargo crosslinking nucleates AP-1 lattice formation. Cell 未提供 神经科学、发育生物学、细胞生物学 Research Article 42805176 10.1016/j.cell.2026.09.022 非 OA / 需订阅访问 A
64 In-cell discovery and characterization of a non-canonical bacterial protein translocation-folding complex. Cell 未提供 细胞生物学、遗传学与基因组学、结构生物学 Research Article 42790421 10.1016/j.cell.2026.08.055 非 OA / 需订阅访问 A
65 Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries. Cell 未提供 细胞生物学、遗传学与基因组学、结构生物学 Research Article 42790420 10.1016/j.cell.2026.08.054 非 OA / 需订阅访问 A
66 Resident tissue macrophages transfer selenium transporter protein to protect pancreatic cancer from ferroptosis. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42785301 10.1016/j.cell.2026.09.001 非 OA / 需订阅访问 A
67 A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42785300 10.1016/j.cell.2026.08.058 非 OA / 需订阅访问 A
68 A geothermal amoeba sets a new upper temperature limit for eukaryotes. Cell 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42772279 10.1016/j.cell.2026.08.043 可能开放获取（PMC ID: PMC13598948） A
69 Chloroplasts balance energy production and stress resilience via a cold-induced signaling pathway. Cell 未提供 肿瘤学、细胞生物学、遗传学与基因组学 Research Article 42759513 10.1016/j.cell.2026.08.041 非 OA / 需订阅访问 A
70 Toward autonomous science with agentic artificial intelligence. Cell 未提供 神经科学、遗传学与基因组学、结构生物学 Review 42753735 10.1016/j.cell.2026.08.052 非 OA / 需订阅访问 A
71 An open benchmark and language models for AI in aging biology. Cell 未提供 遗传学与基因组学、人工智能、蛋白质科学 Research Article 42753698 10.1016/j.cell.2026.08.026 非 OA / 需订阅访问 A
72 scBaseCount: An AI agent-curated, standardized, auto-updated single-cell data repository. Cell 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42753696 10.1016/j.cell.2026.08.025 非 OA / 需订阅访问 A
73 Changing minds: How AI is transforming the life sciences. Cell 未提供 药物研发、人工智能 Research Article 42753695 10.1016/j.cell.2026.08.019 非 OA / 需订阅访问 A
74 Avoiding common failures in AI for health and medicine. Cell 未提供 遗传学与基因组学、人工智能 Review 42753694 10.1016/j.cell.2026.07.025 非 OA / 需订阅访问 A
75 World models for biomedicine. Cell 未提供 细胞生物学、遗传学与基因组学、药物研发 Review 42753693 10.1016/j.cell.2026.08.032 非 OA / 需订阅访问 A
76 A world model of the virtual cell. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Review 42753692 10.1016/j.cell.2026.08.042 非 OA / 需订阅访问 A
77 3D chromatin remodeling during domestication defines novel targets for crop improvement. Cell 未提供 遗传学与基因组学、结构生物学、药物研发 Research Article 42748920 10.1016/j.cell.2026.08.038 非 OA / 需订阅访问 A
78 Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth. Cell 未提供 神经科学、肿瘤学、遗传学与基因组学 Research Article 42743926 10.1016/j.cell.2026.08.037 可能开放获取（PMC ID: PMC13596996） A
79 Mitochondrial ATP promotes T cell differentiation through chromatin accessibility. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42727574 10.1016/j.cell.2026.08.023 非 OA / 需订阅访问 A
80 4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning. Cell 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42721963 10.1016/j.cell.2026.08.028 非 OA / 需订阅访问 A
81 Caloric restriction modulates genome-wide somatic mutation in mice. Cell 未提供 神经科学、遗传学与基因组学、人工智能 Research Article 42716011 10.1016/j.cell.2026.08.013 可能开放获取（PMC ID: PMC13559707） A
82 The complete gustatory connectome of adult Drosophila reveals how taste guides feeding, foraging, and social behavior. Cell 未提供 神经科学、遗传学与基因组学、蛋白质科学 Research Article 42691996 10.1016/j.cell.2026.08.016 非 OA / 需订阅访问 A
83 Sexual dimorphism in the complete Drosophila male central nervous system connectome. Cell 未提供 神经科学、遗传学与基因组学、蛋白质科学 Research Article 42691995 10.1016/j.cell.2026.08.015 非 OA / 需订阅访问 A
84 De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles. Cell 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42679818 10.1016/j.cell.2026.08.007 非 OA / 需订阅访问 A
85 Predicting cellular responses to perturbation across diverse contexts with State. Cell 未提供 发育生物学、细胞生物学、遗传学与基因组学 Research Article 42673963 10.1016/j.cell.2026.07.052 非 OA / 需订阅访问 A
86 Fifteen challenges for generative AI applications to cell biology. Cell 未提供 免疫学、肿瘤学、细胞生物学 Review 42607668 10.1016/j.cell.2026.07.004 非 OA / 需订阅访问 A
87 Why machines don't speak biology: Toward native biological language models. Cell 未提供 药物研发、人工智能 Review 42520803 10.1016/j.cell.2026.07.003 非 OA / 需订阅访问 A
88 Dynamic dimer-of-dimers architecture defines Mg 2+ transport in human CNNM4. Cell 未提供 细胞生物学、结构生物学、药物研发 Research Article 42497866 10.1016/j.cell.2026.06.039 可能开放获取（PMC ID: PMC13479726） A
89 A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42476129 10.1016/j.cell.2026.06.037 可能开放获取（PMC ID: PMC13592201） A
90 Spatial proximity sequencing maps developmental dynamics in the germinal center. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42462709 10.1016/j.cell.2026.06.034 非 OA / 需订阅访问 A
91 Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders. Cell 未提供 神经科学、遗传学与基因组学、蛋白质科学 Research Article 42385702 10.1016/j.cell.2026.06.013 可能开放获取（PMC ID: PMC13340254） A
92 Structural basis for host membrane binding and remodeling by invading malaria parasites. Cell 未提供 细胞生物学、微生物/病毒、人工智能 Research Article 42379167 10.1016/j.cell.2026.06.012 可能开放获取（PMC ID: PMC13322224） A
93 Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine. Cell 未提供 肿瘤学、药物研发、蛋白质科学 Research Article 42276042 10.1016/j.cell.2026.06.007 非 OA / 需订阅访问 A
94 Population-scale immune multiome atlas reveals regulatory disease mechanisms. Nature 未提供 免疫学、遗传学与基因组学、药物研发 Research Article 42816628 10.1038/s41586-026-11078-2 非 OA / 需订阅访问 B
95 Type 2 immune history trains lung macrophages for viral disease tolerance. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42816626 10.1038/s41586-026-11060-y 非 OA / 需订阅访问 B
96 Sugar-rich foods exacerbate antibiotic-induced microbiome disruption. Nature 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42816625 10.1038/s41586-026-11077-3 非 OA / 需订阅访问 B
97 Osteoclasts intercept meningeal lymphatic paths for dural metastasis. Nature 未提供 神经科学、免疫学、肿瘤学 Research Article 42816624 10.1038/s41586-026-11082-6 非 OA / 需订阅访问 B
98 An amygdala to anterior hypothalamic circuit gates stress sensitivity. Nature 未提供 神经科学 Research Article 42816620 10.1038/s41586-026-11075-5 非 OA / 需订阅访问 B
99 Spatiotemporal clonal architecture of the newborn mouse forebrain. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42816613 10.1038/s41586-026-11064-8 非 OA / 需订阅访问 B
100 Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation. Nature 未提供 遗传学与基因组学、药物研发 Research Article 42816612 10.1038/s41586-026-11113-2 非 OA / 需订阅访问 B
101 Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity. Nature 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42816610 10.1038/s41586-026-11087-1 非 OA / 需订阅访问 B
102 A two-hit mechanism triggers autoimmune hair loss. Nature 未提供 神经科学、免疫学、发育生物学 Research Article 42816609 10.1038/s41586-026-11098-y 非 OA / 需订阅访问 B
103 Transcription pause and elongation regulators mediate somatic hypermutation. Nature 未提供 免疫学、遗传学与基因组学、药物研发 Research Article 42816608 10.1038/s41586-026-11092-4 非 OA / 需订阅访问 B
104 Lifespan single-cell transcriptomic atlas of the human prefrontal cortex. Nature 未提供 神经科学、免疫学、发育生物学 Research Article 42778698 10.1038/s41586-026-10271-7 可能开放获取（PMC ID: PMC13600939） B
105 Single-nucleus transcriptome-wide association study of human brain disorders. Nature 未提供 神经科学、免疫学、细胞生物学 Research Article 42778697 10.1038/s41586-026-10836-6 可能开放获取（PMC ID: PMC13600940） B
106 Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion. Nature 未提供 免疫学、肿瘤学、发育生物学 Research Article 42778612 10.1038/s41586-026-11059-5 非 OA / 需订阅访问 B
107 The gene-regulatory evolution of the human skeleton. Nature 未提供 细胞生物学、遗传学与基因组学 Research Article 42778609 10.1038/s41586-026-11053-x 非 OA / 需订阅访问 B
108 Reference genomes and fossils revise bat family phylogeny and biogeography. Nature 未提供 遗传学与基因组学 Research Article 42778608 10.1038/s41586-026-11007-3 可能开放获取（PMC ID: PMC13626947） B
109 mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis. Nature 未提供 神经科学、免疫学、发育生物学 Research Article 42778607 10.1038/s41586-026-11054-w 非 OA / 需订阅访问 B
110 The lipidomic architecture of the mouse brain. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42778605 10.1038/s41586-026-11050-0 可能开放获取（PMC ID: PMC13626954） B
111 Hepatocytes promote liver metastasis of pancreatic cancer by providing serine. Nature 未提供 神经科学、肿瘤学、遗传学与基因组学 Research Article 42778596 10.1038/s41586-026-11051-z 非 OA / 需订阅访问 B
112 A methanogen hydrolase reveals the structure of archaeal peptidoglycan. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42778595 10.1038/s41586-026-11028-y 非 OA / 需订阅访问 B
113 The mutational dynamics of the Arabidopsis centromeres. Nature 未提供 遗传学与基因组学 Research Article 42778594 10.1038/s41586-026-11046-w 非 OA / 需订阅访问 B
114 MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42778593 10.1038/s41586-026-11048-8 非 OA / 需订阅访问 B
115 Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila. Nature 未提供 遗传学与基因组学、药物研发、蛋白质科学 Research Article 42778591 10.1038/s41586-026-11029-x 非 OA / 需订阅访问 B
116 Molecular-level observation of the self-assembly of a virus-like particle. Nature 未提供 发育生物学、细胞生物学、遗传学与基因组学 Research Article 42749916 10.1038/s41586-026-10948-z 可能开放获取（PMC ID: PMC13581590） B
117 Developmental xenocortication using human-derived organoids in mice. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42749812 10.1038/s41586-026-11032-2 非 OA / 需订阅访问 B
118 A retinoic acid autoregulatory loop governing prefrontal-motor arealization. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42749810 10.1038/s41586-026-11014-4 非 OA / 需订阅访问 B
119 Evolution and heterogeneity of lethal metastatic bladder cancer subtypes. Nature 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42749807 10.1038/s41586-026-11035-z 非 OA / 需订阅访问 B
120 Cohesin reshapes replication fork contacts to aid fork slowing and reversal. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42749806 10.1038/s41586-026-11034-0 非 OA / 需订阅访问 B
121 Development of a random background to understand ligand optimization. Nature 未提供 发育生物学、药物研发 Research Article 42749805 10.1038/s41586-026-11013-5 非 OA / 需订阅访问 B
122 Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis. Nature 未提供 遗传学与基因组学 Research Article 42749804 10.1038/s41586-026-11057-7 非 OA / 需订阅访问 B
123 Targeted genomic integration and rearrangement using prime assembly. Nature 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42749803 10.1038/s41586-026-11024-2 非 OA / 需订阅访问 B
124 Transcriptional activation of plant immunity by salicylic acid. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42749801 10.1038/s41586-026-11021-5 非 OA / 需订阅访问 B
125 Topographic structure and function of locus coeruleus noradrenaline neurons. Nature 未提供 神经科学、遗传学与基因组学 Research Article 42749800 10.1038/s41586-026-11026-0 非 OA / 需订阅访问 B
126 Mitochondrial fission factor senses and governs ferroptosis. Nature 未提供 细胞生物学、蛋白质科学 Research Article 42749797 10.1038/s41586-026-11020-6 非 OA / 需订阅访问 B
127 Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors. Nature 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42749286 10.1038/s41586-026-11123-0 非 OA / 需订阅访问 B
128 Inflection points and transitions in Alzheimer's disease. Nature 未提供 神经科学、细胞生物学、遗传学与基因组学 Review 42749285 10.1038/s41586-026-11110-5 非 OA / 需订阅访问 B
129 Highly efficient base editing at PCSK9 and normal human embryo development. Nature 未提供 发育生物学、遗传学与基因组学、药物研发 Research Article 42742174 10.1038/s41586-026-11118-x 非 OA / 需订阅访问 B
130 Integrated signatures define mutational processes in prostate cancer. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42717097 10.1038/s41586-026-10468-w 非 OA / 需订阅访问 B
131 PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity. Nature 未提供 免疫学、肿瘤学、发育生物学 Research Article 42717091 10.1038/s41586-026-10954-1 非 OA / 需订阅访问 B
132 Within-family effect of ancestry on complex traits in a Mexican population. Nature 未提供 遗传学与基因组学 Research Article 42717089 10.1038/s41586-026-11039-9 非 OA / 需订阅访问 B
133 Denisovans from southwestern China and their subsistence strategies. Nature 未提供 遗传学与基因组学、蛋白质科学 Research Article 42717087 10.1038/s41586-026-10997-4 非 OA / 需订阅访问 B
134 Mobile education builds resilience during shocks in five countries. Nature 未提供 遗传学与基因组学、药物研发、生物技术 Research Article 42717082 10.1038/s41586-026-10990-x 可能开放获取（PMC ID: PMC13581608） B
135 A serpin-myeloid axis in pancreatic cancer heterogeneity and immune evasion. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42717081 10.1038/s41586-026-11002-8 非 OA / 需订阅访问 B
136 Molecular mechanisms and pathogenesis of MASH. Nature 未提供 免疫学、肿瘤学、细胞生物学 Review 42687025 10.1038/s41586-026-10529-0 非 OA / 需订阅访问 B
137 Current therapeutic landscape and future treatment perspectives of MASH. Nature 未提供 免疫学、肿瘤学、细胞生物学 Review 42687024 10.1038/s41586-026-10672-8 非 OA / 需订阅访问 B
138 Functional chimeric mRNAs encode proteins in mammalian immunity. Nature 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42686912 10.1038/s41586-026-10982-x 非 OA / 需订阅访问 B
139 Robust inference and correlates from genetic associations with personality. Nature 未提供 遗传学与基因组学、药物研发 Research Article 42686911 10.1038/s41586-026-10992-9 可能开放获取（PMC ID: PMC13589609） B
140 Intracellular complement factor H protects neurons during CNS inflammation. Nature 未提供 神经科学、免疫学、细胞生物学 Research Article 42686909 10.1038/s41586-026-10981-y 非 OA / 需订阅访问 B
141 Structure and operating principles of a monkeypox virus replisome. Nature 未提供 遗传学与基因组学、结构生物学、微生物/病毒 Research Article 42686903 10.1038/s41586-026-10937-2 非 OA / 需订阅访问 B
142 Long-read sequencing reveals pre-meiotic gene conversion in sperm. Nature 未提供 遗传学与基因组学 Research Article 42649296 10.1038/s41586-026-10901-0 可能开放获取（PMC ID: PMC13600919） B
143 Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42649293 10.1038/s41586-026-10927-4 非 OA / 需订阅访问 B
144 Phase-homogeneous mixed-halide perovskites for stable tandem photovoltaics. Nature 未提供 遗传学与基因组学 Research Article 42649283 10.1038/s41586-026-10929-2 非 OA / 需订阅访问 B
145 RNA synthesis and substrate analogue inhibition in the CCHFV polymerase. Nature 未提供 遗传学与基因组学、结构生物学、微生物/病毒 Research Article 42649282 10.1038/s41586-026-10913-w 非 OA / 需订阅访问 B
146 Glucose-responsive probiotics for glycaemic modulation in mice and monkeys. Nature 未提供 发育生物学、遗传学与基因组学、药物研发 Research Article 42587154 10.1038/s41586-026-10909-6 非 OA / 需订阅访问 B
147 A dependency map enhanced with next-generation 3D cancer models. Nature 未提供 肿瘤学、细胞生物学、遗传学与基因组学 Research Article 42557315 10.1038/s41586-026-10843-7 可能开放获取（PMC ID: PMC13581591） B
148 Stimulation modulates gene-linked cell assemblies in the human brain. Nature 未提供 神经科学、遗传学与基因组学、药物研发 Research Article 42557314 10.1038/s41586-026-10879-9 非 OA / 需订阅访问 B
149 Structures and inhibition of the Crimean-Congo haemorrhagic fever virus polymerase. Nature 未提供 免疫学、发育生物学、细胞生物学 Research Article 42486991 10.1038/s41586-026-10701-6 非 OA / 需订阅访问 B
150 Exceptional brain and ecological diversity in the earliest snakes. Nature 未提供 神经科学、药物研发 Research Article 42486987 10.1038/s41586-026-10809-9 可能开放获取（PMC ID: PMC13538052） B
151 Efficient and precise programmable DNA knock-in without double-strand breaks. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42486986 10.1038/s41586-026-10819-7 非 OA / 需订阅访问 B
152 CRISPR-Cas regulates expression of embedded anti-phage defence systems. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42486981 10.1038/s41586-026-10833-9 非 OA / 需订阅访问 B
153 Brown bullhead catfish melanoma represents a novel transmissible cancer. Nature 未提供 肿瘤学、细胞生物学、遗传学与基因组学 Research Article 42486978 10.1038/s41586-026-10828-6 可能开放获取（PMC ID: PMC13538035） B
154 Genetic background sets the trajectory of experimental cancer evolution. Nature 未提供 肿瘤学、发育生物学、遗传学与基因组学 Research Article 42486977 10.1038/s41586-026-10821-z 可能开放获取（PMC ID: PMC13600922） B
155 A global molecular code for birth order and neuronal identity in Drosophila. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42486976 10.1038/s41586-026-10797-w 可能开放获取（PMC ID: PMC13538039） B
156 Prior therapy defines mutation profiles in childhood cancer at relapse. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42486975 10.1038/s41586-026-10803-1 可能开放获取（PMC ID: PMC13581601） B
157 The planktonic microbiome of the Great Barrier Reef. Nature 未提供 遗传学与基因组学、微生物/病毒 Research Article 42486971 10.1038/s41586-026-10778-z 可能开放获取（PMC ID: PMC13558084） B
158 GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42457964 10.1038/s41586-026-10786-z 非 OA / 需订阅访问 B
159 Cell-type signatures of Alzheimer's disease shared across population groups. Nature 未提供 神经科学、遗传学与基因组学、生物技术 Research Article 42457956 10.1038/s41586-026-10793-0 可能开放获取（PMC ID: PMC13538069） B
160 Diet-microbiome synergy underlies obesity-associated immunotherapy efficacy. Nature 未提供 免疫学、肿瘤学、微生物/病毒 Research Article 42420462 10.1038/s41586-026-10750-x 可能开放获取（PMC ID: PMC13558080） B
161 Gut microbiota primes stroke severity via the AHR in intestinal dendritic cells. Cell 未提供 神经科学、免疫学、遗传学与基因组学 Research Article 42810339 10.1016/j.cell.2026.09.013 非 OA / 需订阅访问 B
162 Microbiome signatures linked to cancer and treatment adverse events in a real-world cohort. Cell 未提供 肿瘤学、遗传学与基因组学、微生物/病毒 Research Article 42810338 10.1016/j.cell.2026.09.009 非 OA / 需订阅访问 B
163 Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound. Cell 未提供 神经科学、遗传学与基因组学、微生物/病毒 Research Article 42805175 10.1016/j.cell.2026.09.005 非 OA / 需订阅访问 B
164 Opposing functions of gut immunomodulatory metabolites on CAR-T therapy. Cell 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42805174 10.1016/j.cell.2026.09.004 非 OA / 需订阅访问 B
165 Shifts in embryonic oxygen levels cue heterochrony in limb initiation. Cell 未提供 发育生物学、遗传学与基因组学 Research Article 42785299 10.1016/j.cell.2026.08.051 可能开放获取（PMC ID: PMC13636768） B
166 CD4 T cells convert transient responses to KRAS inhibition to durable remissions in pancreatic cancer. Cell 未提供 免疫学、肿瘤学、药物研发 Research Article 42777708 10.1016/j.cell.2026.08.045 非 OA / 需订阅访问 B
167 Projection-defined modules reveal mouse motor cortex architecture. Cell 未提供 神经科学、药物研发 Research Article 42777707 10.1016/j.cell.2026.08.046 非 OA / 需订阅访问 B
168 Direct cell-to-cell transmission of retrotransposons. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42777706 10.1016/j.cell.2026.08.047 非 OA / 需订阅访问 B
169 Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42772280 10.1016/j.cell.2026.08.049 非 OA / 需订阅访问 B
170 Oligodendrocytes in central nervous system health and disease. Cell 未提供 神经科学、发育生物学、细胞生物学 Review 42759515 10.1016/j.cell.2026.08.003 非 OA / 需订阅访问 B
171 mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia. Cell 未提供 免疫学、遗传学与基因组学、药物研发 Research Article 42759514 10.1016/j.cell.2026.08.039 非 OA / 需订阅访问 B
172 Tahoe-100M: Mapping drug-induced molecular phenotypes at single-cell resolution. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42753697 10.1016/j.cell.2026.08.035 非 OA / 需订阅访问 B
173 Single-cell-resolved genome atlas of prokaryoplankton inhabiting the ocean's interior. Cell 未提供 遗传学与基因组学、微生物/病毒、生物技术 Research Article 42743927 10.1016/j.cell.2026.08.036 非 OA / 需订阅访问 B
174 Programmed ribosomal frameshifting triggers translational stress to promote viral replication. Cell 未提供 遗传学与基因组学、微生物/病毒、蛋白质科学 Research Article 42743925 10.1016/j.cell.2026.08.031 非 OA / 需订阅访问 B
175 Copper ion-induced MYH9 polymerization executes cuproptosis. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42735689 10.1016/j.cell.2026.08.030 非 OA / 需订阅访问 B
176 Norway spruce spatiotemporal programs of conifer reproductive development. Cell 未提供 发育生物学、遗传学与基因组学、生物技术 Research Article 42735688 10.1016/j.cell.2026.08.033 非 OA / 需订阅访问 B
177 Glycocalyx-edited mesenchymal stem/stromal cell therapy in advanced osteoporosis. Cell 未提供 遗传学与基因组学、药物研发、生物技术 Research Article 42727576 10.1016/j.cell.2026.08.017 非 OA / 需订阅访问 B
178 Metax enables accurate cross-domain taxonomic profiling of metagenomes. Cell 未提供 遗传学与基因组学、微生物/病毒 Research Article 42727575 10.1016/j.cell.2026.08.024 非 OA / 需订阅访问 B
179 Architecture of the serotonergic projectome in the mouse brain. Cell 未提供 神经科学、药物研发 Research Article 42721962 10.1016/j.cell.2026.08.022 非 OA / 需订阅访问 B
180 Identification of the tendon/ligament stem cell in mice and humans. Cell 未提供 发育生物学、细胞生物学、遗传学与基因组学 Research Article 42705230 10.1016/j.cell.2026.08.018 非 OA / 需订阅访问 B
181 The organization of visual pathways in the Drosophila brain. Cell 未提供 神经科学 Research Article 42691997 10.1016/j.cell.2026.08.014 非 OA / 需订阅访问 B
182 The regulatory logic linking inflammation and fibrosis. Cell 未提供 免疫学、发育生物学、细胞生物学 Review 42691994 10.1016/j.cell.2026.08.001 非 OA / 需订阅访问 B
183 Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types. Cell 未提供 细胞生物学、遗传学与基因组学、生物技术 Research Article 42685689 10.1016/j.cell.2026.08.010 非 OA / 需订阅访问 B
184 Live-cell transcriptomics with engineered virus-like particles. Cell 未提供 免疫学、发育生物学、细胞生物学 Research Article 42679822 10.1016/j.cell.2026.08.005 可能开放获取（PMC ID: PMC13618706） B
185 Oxygen-responsive bacterial glycosphingolipid links symbiont fitness and immune development in neonatal host. Cell 未提供 免疫学、发育生物学、细胞生物学 Research Article 42679821 10.1016/j.cell.2026.08.011 可能开放获取（PMC ID: PMC13573233） B
186 Ratiometric transcriptional activation by protein degradation. Cell 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42679820 10.1016/j.cell.2026.08.009 非 OA / 需订阅访问 B
187 Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42679819 10.1016/j.cell.2026.08.006 非 OA / 需订阅访问 B
188 Virtual Cell Challenge 2026: Benchmarking zero-shot generalization across cellular contexts. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42648290 10.1016/j.cell.2026.08.004 非 OA / 需订阅访问 B
189 Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function. Cell 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42617595 10.1016/j.cell.2026.07.054 非 OA / 需订阅访问 B
190 Polyamines buffer labile iron to suppress ferroptosis. Cell 未提供 细胞生物学、遗传学与基因组学、生物技术 Research Article 42600612 10.1016/j.cell.2026.07.040 可能开放获取（PMC ID: PMC13527661） B
191 Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis. Cell 未提供 神经科学、免疫学、细胞生物学 Research Article 42551425 10.1016/j.cell.2026.07.008 可能开放获取（PMC ID: PMC13480947） B
192 Targeting peripheral 5-HT 2A R enhances antitumor immunity in colorectal cancer. Cell 未提供 神经科学、免疫学、肿瘤学 Research Article 42551424 10.1016/j.cell.2026.07.028 非 OA / 需订阅访问 B
193 Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer. Cell 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42556334 10.1016/j.cell.2026.07.031 非 OA / 需订阅访问 B
194 Spatial atlas of the human brain vasculature reveals specialized cell ensembles. Cell 未提供 神经科学、免疫学、遗传学与基因组学 Research Article 42537647 10.1016/j.cell.2026.07.007 可能开放获取（PMC ID: PMC13577656） B
195 Dietary arginine drives codon-dependent MHC class I translation and improves immunity in colon tumorigenesis and respiratory viral infection. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42532044 10.1016/j.cell.2026.07.020 非 OA / 需订阅访问 B
196 Basement membrane turnover controls cell shape. Cell 未提供 免疫学、细胞生物学 Research Article 42532043 10.1016/j.cell.2026.07.010 可能开放获取（PMC ID: PMC13536978） B
197 Advancing cancer detection and treatment using longitudinal routine clinical data. Cell 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42508404 10.1016/j.cell.2026.07.009 非 OA / 需订阅访问 B
198 The intrinsic cardiac nervous system is essential for cardiac function and survival. Cell 未提供 神经科学、遗传学与基因组学、药物研发 Research Article 42486084 10.1016/j.cell.2026.06.040 可能开放获取（PMC ID: PMC13527665） B
199 Localized PD-1 CAR T therapy reprograms neuroinflammation. Cell 未提供 神经科学、免疫学、肿瘤学 Research Article 42480527 10.1016/j.cell.2026.06.036 非 OA / 需订阅访问 B
200 Boron-bridged GIPCs stabilize cell wall anchoring and PIN polar domains. Cell 未提供 发育生物学、细胞生物学、药物研发 Research Article 42462711 10.1016/j.cell.2026.06.028 非 OA / 需订阅访问 B
201 Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42462710 10.1016/j.cell.2026.06.027 非 OA / 需订阅访问 B
202 Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs. Cell 未提供 发育生物学、细胞生物学、遗传学与基因组学 Research Article 42385704 10.1016/j.cell.2026.06.015 非 OA / 需订阅访问 B
203 Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis. Cell 未提供 发育生物学、遗传学与基因组学、生物技术 Research Article 42385701 10.1016/j.cell.2026.06.014 可能开放获取（PMC ID: PMC13379681） B
204 The anthropogenic fingerprint on emerging infectious diseases. Nature 未提供 微生物/病毒、人工智能 Research Article 42778602 10.1038/s41586-026-11058-6 非 OA / 需订阅访问 C
205 Anodic Pd membrane H 2 extraction enhances thermochemical dehydrogenation. Nature 未提供 细胞生物学 Research Article 42717090 10.1038/s41586-026-11008-2 非 OA / 需订阅访问 C
206 Designing physics experiments with artificial intelligence. Nature 未提供 人工智能 Review 42687023 10.1038/s41586-026-10898-6 非 OA / 需订阅访问 C
207 Reconstituting human primitive streak formation through extra-embryonic cell coordination. Cell 未提供 发育生物学 Research Article 42341759 10.1016/j.cell.2026.05.045 非 OA / 需订阅访问 C

二、按期刊分类列表

Nature

  • PMID 42816619 — GPCR antagonism via rewiring of receptor trafficking and degradation. (Research Article, 推荐等级 A)
  • PMID 42816618 — Dynamic protrusions mediate crawling motility in Asgard archaea. (Research Article, 推荐等级 A)
  • PMID 42816614 — γδ T cell receptor dependencies define a unique immunosurveillance modality. (Research Article, 推荐等级 A)
  • PMID 42816607 — Prion-like transmission of human tau strains in the mouse brain. (Research Article, 推荐等级 A)
  • PMID 42816606 — Function-preserving watermarking of AI-generated proteins. (Research Article, 推荐等级 A)
  • PMID 42816559 — Written in development and lost in ageing: the grammar of cellular identity. (Review, 推荐等级 A)
  • PMID 42816558 — Scalable decision-making for games of imperfect information. (Research Article, 推荐等级 A)
  • PMID 42778699 — Single-cell atlas of transcriptomic vulnerability across brain disorders. (Research Article, 推荐等级 A)
  • PMID 42778610 — TRAM promotes Toll-like-receptor-free myddosome signal transduction. (Research Article, 推荐等级 A)
  • PMID 42778601 — A design approach for bitopic kinase inhibitors. (Research Article, 推荐等级 A)
  • PMID 42778590 — Lsp2 links early-life diet to adult translation and lifespan in Drosophila. (Research Article, 推荐等级 A)
  • PMID 42778177 — Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes. (Research Article, 推荐等级 A)
  • PMID 42767646 — Chemist-aligned retrosynthesis by ensembling diverse inductive bias models. (Research Article, 推荐等级 A)
  • PMID 42749917 — A thermodynamically favoured molecular computer. (Research Article, 推荐等级 A)
  • PMID 42749809 — Rapid patient-specific neural networks for X-ray to volume registration. (Research Article, 推荐等级 A)
  • PMID 42749808 — Reimagining research papers as interactive and reliable AI agents. (Research Article, 推荐等级 A)
  • PMID 42749802 — Identification of broadly tumour-reactive γδ TCRs from multiple myeloma. (Research Article, 推荐等级 A)
  • PMID 42749798 — Mutational constraints on RSV F and its neutralization by antibodies. (Research Article, 推荐等级 A)
  • PMID 42744304 — Quality control of glycogen through direct ubiquitylation by RNF213. (Research Article, 推荐等级 A)
  • PMID 42742175 — Encoded and non-genetic protein variants expand human functional proteome. (Research Article, 推荐等级 A)
  • PMID 42742168 — Phosphine-mediated azine C-H couplings with water and ammonia. (Research Article, 推荐等级 A)
  • PMID 42717098 — An operational perturbation proteomics-based virtual cell model. (Research Article, 推荐等级 A)
  • PMID 42717095 — Imaging cellular activity across all organs reveals body-wide circuits. (Research Article, 推荐等级 A)
  • PMID 42717093 — TRI-611, a selective, brain-penetrant molecular glue degrader of ALK. (Research Article, 推荐等级 A)
  • PMID 42717092 — Proximity-guided graph learning reveals tumour-associated proximity antigens. (Research Article, 推荐等级 A)
  • PMID 42717086 — Predicting genome-wide functional constraints with GPN-Star. (Research Article, 推荐等级 A)
  • PMID 42717085 — Breaking timescales with generative sampling of conformational transitions. (Research Article, 推荐等级 A)
  • PMID 42717083 — TM184C is a GPCR-like regulator of intercellular exchange and autophagy. (Research Article, 推荐等级 A)
  • PMID 42717078 — Operational tropical cyclone forecasting with AI. (Research Article, 推荐等级 A)
  • PMID 42687026 — Explainable deep learning improves human mental models of self-driving cars. (Research Article, 推荐等级 A)
  • PMID 42686908 — Creating bottom-up RNA transfer vehicles from synthetic protein assemblies. (Research Article, 推荐等级 A)
  • PMID 42686907 — 3D epigenome of glial cell types in developing human cortex. (Research Article, 推荐等级 A)
  • PMID 42686906 — Late-life semaglutide treatment slows ageing and extends lifespan in female mice. (Research Article, 推荐等级 A)
  • PMID 42686904 — Probing far-from-equilibrium dynamics of electrical double layers. (Research Article, 推荐等级 A)
  • PMID 42686902 — Connectome analysis of a cerebellum-like circuit for sensory prediction. (Research Article, 推荐等级 A)
  • PMID 42686901 — Rewiring the ribosome to translate proteins encoded in its own RNA. (Research Article, 推荐等级 A)
  • PMID 42618795 — Human brain organoids record the passage of time over multiple years. (Research Article, 推荐等级 A)
  • PMID 42618782 — The HydroGym reinforcement learning platform for fluid dynamics. (Research Article, 推荐等级 A)
  • PMID 42587155 — Luminescent-reaction-enabled super-resolution imaging. (Research Article, 推荐等级 A)
  • PMID 42587147 — Rb-driven transcription limits its tumour-suppressive effects in breast cancer. (Research Article, 推荐等级 A)
  • PMID 42557334 — An expanded codebook of human transcription factor DNA-binding specificity. (Research Article, 推荐等级 A)
  • PMID 42557333 — An ancient mitochondrial program tunes translation to haem availability. (Research Article, 推荐等级 A)
  • PMID 42557331 — The Virtual Tissues foundation model resolves spatial proteomics across scales. (Research Article, 推荐等级 A)
  • PMID 42557330 — ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer. (Research Article, 推荐等级 A)
  • PMID 42557329 — DCAF11-dependent molecular glue degrader activated by glutathionylation. (Research Article, 推荐等级 A)
  • PMID 42557328 — Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours. (Research Article, 推荐等级 A)
  • PMID 42557325 — Antigen presentation by CD40 + MHC-II + astrocytes promotes CNS autoimmunity. (Research Article, 推荐等级 A)
  • PMID 42557324 — Uncovering the mechanism of female restitution in sugarcane hybrids. (Research Article, 推荐等级 A)
  • PMID 42557320 — A tumour-derived organoid biobank maps cancer gene dependencies. (Research Article, 推荐等级 A)
  • PMID 42557317 — FNIP1 variants are associated with favourable metabolism in 1 million humans. (Research Article, 推荐等级 A)
  • PMID 42557316 — A compendium of next-generation patient-derived models for diverse cancers. (Research Article, 推荐等级 A)
  • PMID 42527607 — Diverse bacterial pattern recognition receptors sense the core phage proteome. (Research Article, 推荐等级 A)
  • PMID 42527603 — Miniaturizing and modifying natural proteins with Raygun. (Research Article, 推荐等级 A)
  • PMID 42486990 — Subnuclear genome compartmentalization controls bivalent chromatin activity. (Research Article, 推荐等级 A)
  • PMID 42486980 — AI-redesigned starting points and outcomes enhance protein evolution. (Research Article, 推荐等级 A)
  • PMID 42457959 — An encyclopedia of human enhancer-gene regulatory interactions. (Research Article, 推荐等级 A)
  • PMID 42457957 — Modular in vivo antibody-ADC click to reverse drug resistance in tumours. (Research Article, 推荐等级 A)
  • PMID 42420452 — Aneuploidy selects for the acquisition of driver genes in breast cancer. (Research Article, 推荐等级 A)
  • PMID 42420447 — An intrinsic cytoskeletal oscillator establishes neuronal polarity. (Research Article, 推荐等级 A)
  • PMID 42420446 — Non-genotoxic transplantation and in vivo selection through epitope editing. (Research Article, 推荐等级 A)
  • PMID 42816628 — Population-scale immune multiome atlas reveals regulatory disease mechanisms. (Research Article, 推荐等级 B)
  • PMID 42816626 — Type 2 immune history trains lung macrophages for viral disease tolerance. (Research Article, 推荐等级 B)
  • PMID 42816625 — Sugar-rich foods exacerbate antibiotic-induced microbiome disruption. (Research Article, 推荐等级 B)
  • PMID 42816624 — Osteoclasts intercept meningeal lymphatic paths for dural metastasis. (Research Article, 推荐等级 B)
  • PMID 42816620 — An amygdala to anterior hypothalamic circuit gates stress sensitivity. (Research Article, 推荐等级 B)
  • PMID 42816613 — Spatiotemporal clonal architecture of the newborn mouse forebrain. (Research Article, 推荐等级 B)
  • PMID 42816612 — Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation. (Research Article, 推荐等级 B)
  • PMID 42816610 — Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity. (Research Article, 推荐等级 B)
  • PMID 42816609 — A two-hit mechanism triggers autoimmune hair loss. (Research Article, 推荐等级 B)
  • PMID 42816608 — Transcription pause and elongation regulators mediate somatic hypermutation. (Research Article, 推荐等级 B)
  • PMID 42778698 — Lifespan single-cell transcriptomic atlas of the human prefrontal cortex. (Research Article, 推荐等级 B)
  • PMID 42778697 — Single-nucleus transcriptome-wide association study of human brain disorders. (Research Article, 推荐等级 B)
  • PMID 42778612 — Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion. (Research Article, 推荐等级 B)
  • PMID 42778609 — The gene-regulatory evolution of the human skeleton. (Research Article, 推荐等级 B)
  • PMID 42778608 — Reference genomes and fossils revise bat family phylogeny and biogeography. (Research Article, 推荐等级 B)
  • PMID 42778607 — mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis. (Research Article, 推荐等级 B)
  • PMID 42778605 — The lipidomic architecture of the mouse brain. (Research Article, 推荐等级 B)
  • PMID 42778596 — Hepatocytes promote liver metastasis of pancreatic cancer by providing serine. (Research Article, 推荐等级 B)
  • PMID 42778595 — A methanogen hydrolase reveals the structure of archaeal peptidoglycan. (Research Article, 推荐等级 B)
  • PMID 42778594 — The mutational dynamics of the Arabidopsis centromeres. (Research Article, 推荐等级 B)
  • PMID 42778593 — MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness. (Research Article, 推荐等级 B)
  • PMID 42778591 — Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila. (Research Article, 推荐等级 B)
  • PMID 42749916 — Molecular-level observation of the self-assembly of a virus-like particle. (Research Article, 推荐等级 B)
  • PMID 42749812 — Developmental xenocortication using human-derived organoids in mice. (Research Article, 推荐等级 B)
  • PMID 42749810 — A retinoic acid autoregulatory loop governing prefrontal-motor arealization. (Research Article, 推荐等级 B)
  • PMID 42749807 — Evolution and heterogeneity of lethal metastatic bladder cancer subtypes. (Research Article, 推荐等级 B)
  • PMID 42749806 — Cohesin reshapes replication fork contacts to aid fork slowing and reversal. (Research Article, 推荐等级 B)
  • PMID 42749805 — Development of a random background to understand ligand optimization. (Research Article, 推荐等级 B)
  • PMID 42749804 — Sex without crossovers mimics clonal reproduction in Rhynchospora tenuis. (Research Article, 推荐等级 B)
  • PMID 42749803 — Targeted genomic integration and rearrangement using prime assembly. (Research Article, 推荐等级 B)
  • PMID 42749801 — Transcriptional activation of plant immunity by salicylic acid. (Research Article, 推荐等级 B)
  • PMID 42749800 — Topographic structure and function of locus coeruleus noradrenaline neurons. (Research Article, 推荐等级 B)
  • PMID 42749797 — Mitochondrial fission factor senses and governs ferroptosis. (Research Article, 推荐等级 B)
  • PMID 42749286 — Mechanisms of Transcriptional Regulation by Salicylic Acid Receptors. (Research Article, 推荐等级 B)
  • PMID 42749285 — Inflection points and transitions in Alzheimer's disease. (Review, 推荐等级 B)
  • PMID 42742174 — Highly efficient base editing at PCSK9 and normal human embryo development. (Research Article, 推荐等级 B)
  • PMID 42717097 — Integrated signatures define mutational processes in prostate cancer. (Research Article, 推荐等级 B)
  • PMID 42717091 — PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity. (Research Article, 推荐等级 B)
  • PMID 42717089 — Within-family effect of ancestry on complex traits in a Mexican population. (Research Article, 推荐等级 B)
  • PMID 42717087 — Denisovans from southwestern China and their subsistence strategies. (Research Article, 推荐等级 B)
  • PMID 42717082 — Mobile education builds resilience during shocks in five countries. (Research Article, 推荐等级 B)
  • PMID 42717081 — A serpin-myeloid axis in pancreatic cancer heterogeneity and immune evasion. (Research Article, 推荐等级 B)
  • PMID 42687025 — Molecular mechanisms and pathogenesis of MASH. (Review, 推荐等级 B)
  • PMID 42687024 — Current therapeutic landscape and future treatment perspectives of MASH. (Review, 推荐等级 B)
  • PMID 42686912 — Functional chimeric mRNAs encode proteins in mammalian immunity. (Research Article, 推荐等级 B)
  • PMID 42686911 — Robust inference and correlates from genetic associations with personality. (Research Article, 推荐等级 B)
  • PMID 42686909 — Intracellular complement factor H protects neurons during CNS inflammation. (Research Article, 推荐等级 B)
  • PMID 42686903 — Structure and operating principles of a monkeypox virus replisome. (Research Article, 推荐等级 B)
  • PMID 42649296 — Long-read sequencing reveals pre-meiotic gene conversion in sperm. (Research Article, 推荐等级 B)
  • PMID 42649293 — Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG. (Research Article, 推荐等级 B)
  • PMID 42649283 — Phase-homogeneous mixed-halide perovskites for stable tandem photovoltaics. (Research Article, 推荐等级 B)
  • PMID 42649282 — RNA synthesis and substrate analogue inhibition in the CCHFV polymerase. (Research Article, 推荐等级 B)
  • PMID 42587154 — Glucose-responsive probiotics for glycaemic modulation in mice and monkeys. (Research Article, 推荐等级 B)
  • PMID 42557315 — A dependency map enhanced with next-generation 3D cancer models. (Research Article, 推荐等级 B)
  • PMID 42557314 — Stimulation modulates gene-linked cell assemblies in the human brain. (Research Article, 推荐等级 B)
  • PMID 42486991 — Structures and inhibition of the Crimean-Congo haemorrhagic fever virus polymerase. (Research Article, 推荐等级 B)
  • PMID 42486987 — Exceptional brain and ecological diversity in the earliest snakes. (Research Article, 推荐等级 B)
  • PMID 42486986 — Efficient and precise programmable DNA knock-in without double-strand breaks. (Research Article, 推荐等级 B)
  • PMID 42486981 — CRISPR-Cas regulates expression of embedded anti-phage defence systems. (Research Article, 推荐等级 B)
  • PMID 42486978 — Brown bullhead catfish melanoma represents a novel transmissible cancer. (Research Article, 推荐等级 B)
  • PMID 42486977 — Genetic background sets the trajectory of experimental cancer evolution. (Research Article, 推荐等级 B)
  • PMID 42486976 — A global molecular code for birth order and neuronal identity in Drosophila. (Research Article, 推荐等级 B)
  • PMID 42486975 — Prior therapy defines mutation profiles in childhood cancer at relapse. (Research Article, 推荐等级 B)
  • PMID 42486971 — The planktonic microbiome of the Great Barrier Reef. (Research Article, 推荐等级 B)
  • PMID 42457964 — GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma. (Research Article, 推荐等级 B)
  • PMID 42457956 — Cell-type signatures of Alzheimer's disease shared across population groups. (Research Article, 推荐等级 B)
  • PMID 42420462 — Diet-microbiome synergy underlies obesity-associated immunotherapy efficacy. (Research Article, 推荐等级 B)
  • PMID 42778602 — The anthropogenic fingerprint on emerging infectious diseases. (Research Article, 推荐等级 C)
  • PMID 42717090 — Anodic Pd membrane H 2 extraction enhances thermochemical dehydrogenation. (Research Article, 推荐等级 C)
  • PMID 42687023 — Designing physics experiments with artificial intelligence. (Review, 推荐等级 C)

Science

本月无纳入文献。

Cell

  • PMID 42815464 — Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1. (Research Article, 推荐等级 A)
  • PMID 42810340 — Spatial evolution of a cachexia-promoting microenvironment in pancreatic cancer. (Research Article, 推荐等级 A)
  • PMID 42805176 — Cargo crosslinking nucleates AP-1 lattice formation. (Research Article, 推荐等级 A)
  • PMID 42790421 — In-cell discovery and characterization of a non-canonical bacterial protein translocation-folding complex. (Research Article, 推荐等级 A)
  • PMID 42790420 — Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries. (Research Article, 推荐等级 A)
  • PMID 42785301 — Resident tissue macrophages transfer selenium transporter protein to protect pancreatic cancer from ferroptosis. (Research Article, 推荐等级 A)
  • PMID 42785300 — A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration. (Research Article, 推荐等级 A)
  • PMID 42772279 — A geothermal amoeba sets a new upper temperature limit for eukaryotes. (Research Article, 推荐等级 A)
  • PMID 42759513 — Chloroplasts balance energy production and stress resilience via a cold-induced signaling pathway. (Research Article, 推荐等级 A)
  • PMID 42753735 — Toward autonomous science with agentic artificial intelligence. (Review, 推荐等级 A)
  • PMID 42753698 — An open benchmark and language models for AI in aging biology. (Research Article, 推荐等级 A)
  • PMID 42753696 — scBaseCount: An AI agent-curated, standardized, auto-updated single-cell data repository. (Research Article, 推荐等级 A)
  • PMID 42753695 — Changing minds: How AI is transforming the life sciences. (Research Article, 推荐等级 A)
  • PMID 42753694 — Avoiding common failures in AI for health and medicine. (Review, 推荐等级 A)
  • PMID 42753693 — World models for biomedicine. (Review, 推荐等级 A)
  • PMID 42753692 — A world model of the virtual cell. (Review, 推荐等级 A)
  • PMID 42748920 — 3D chromatin remodeling during domestication defines novel targets for crop improvement. (Research Article, 推荐等级 A)
  • PMID 42743926 — Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth. (Research Article, 推荐等级 A)
  • PMID 42727574 — Mitochondrial ATP promotes T cell differentiation through chromatin accessibility. (Research Article, 推荐等级 A)
  • PMID 42721963 — 4D spatiotemporal landscape of mitochondrial phenotypes across cellular states unlocked through representation learning. (Research Article, 推荐等级 A)
  • PMID 42716011 — Caloric restriction modulates genome-wide somatic mutation in mice. (Research Article, 推荐等级 A)
  • PMID 42691996 — The complete gustatory connectome of adult Drosophila reveals how taste guides feeding, foraging, and social behavior. (Research Article, 推荐等级 A)
  • PMID 42691995 — Sexual dimorphism in the complete Drosophila male central nervous system connectome. (Research Article, 推荐等级 A)
  • PMID 42679818 — De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles. (Research Article, 推荐等级 A)
  • PMID 42673963 — Predicting cellular responses to perturbation across diverse contexts with State. (Research Article, 推荐等级 A)
  • PMID 42607668 — Fifteen challenges for generative AI applications to cell biology. (Review, 推荐等级 A)
  • PMID 42520803 — Why machines don't speak biology: Toward native biological language models. (Review, 推荐等级 A)
  • PMID 42497866 — Dynamic dimer-of-dimers architecture defines Mg 2+ transport in human CNNM4. (Research Article, 推荐等级 A)
  • PMID 42476129 — A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death. (Research Article, 推荐等级 A)
  • PMID 42462709 — Spatial proximity sequencing maps developmental dynamics in the germinal center. (Research Article, 推荐等级 A)
  • PMID 42385702 — Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders. (Research Article, 推荐等级 A)
  • PMID 42379167 — Structural basis for host membrane binding and remodeling by invading malaria parasites. (Research Article, 推荐等级 A)
  • PMID 42276042 — Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine. (Research Article, 推荐等级 A)
  • PMID 42810339 — Gut microbiota primes stroke severity via the AHR in intestinal dendritic cells. (Research Article, 推荐等级 B)
  • PMID 42810338 — Microbiome signatures linked to cancer and treatment adverse events in a real-world cohort. (Research Article, 推荐等级 B)
  • PMID 42805175 — Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound. (Research Article, 推荐等级 B)
  • PMID 42805174 — Opposing functions of gut immunomodulatory metabolites on CAR-T therapy. (Research Article, 推荐等级 B)
  • PMID 42785299 — Shifts in embryonic oxygen levels cue heterochrony in limb initiation. (Research Article, 推荐等级 B)
  • PMID 42777708 — CD4 T cells convert transient responses to KRAS inhibition to durable remissions in pancreatic cancer. (Research Article, 推荐等级 B)
  • PMID 42777707 — Projection-defined modules reveal mouse motor cortex architecture. (Research Article, 推荐等级 B)
  • PMID 42777706 — Direct cell-to-cell transmission of retrotransposons. (Research Article, 推荐等级 B)
  • PMID 42772280 — Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation. (Research Article, 推荐等级 B)
  • PMID 42759515 — Oligodendrocytes in central nervous system health and disease. (Review, 推荐等级 B)
  • PMID 42759514 — mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia. (Research Article, 推荐等级 B)
  • PMID 42753697 — Tahoe-100M: Mapping drug-induced molecular phenotypes at single-cell resolution. (Research Article, 推荐等级 B)
  • PMID 42743927 — Single-cell-resolved genome atlas of prokaryoplankton inhabiting the ocean's interior. (Research Article, 推荐等级 B)
  • PMID 42743925 — Programmed ribosomal frameshifting triggers translational stress to promote viral replication. (Research Article, 推荐等级 B)
  • PMID 42735689 — Copper ion-induced MYH9 polymerization executes cuproptosis. (Research Article, 推荐等级 B)
  • PMID 42735688 — Norway spruce spatiotemporal programs of conifer reproductive development. (Research Article, 推荐等级 B)
  • PMID 42727576 — Glycocalyx-edited mesenchymal stem/stromal cell therapy in advanced osteoporosis. (Research Article, 推荐等级 B)
  • PMID 42727575 — Metax enables accurate cross-domain taxonomic profiling of metagenomes. (Research Article, 推荐等级 B)
  • PMID 42721962 — Architecture of the serotonergic projectome in the mouse brain. (Research Article, 推荐等级 B)
  • PMID 42705230 — Identification of the tendon/ligament stem cell in mice and humans. (Research Article, 推荐等级 B)
  • PMID 42691997 — The organization of visual pathways in the Drosophila brain. (Research Article, 推荐等级 B)
  • PMID 42691994 — The regulatory logic linking inflammation and fibrosis. (Review, 推荐等级 B)
  • PMID 42685689 — Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types. (Research Article, 推荐等级 B)
  • PMID 42679822 — Live-cell transcriptomics with engineered virus-like particles. (Research Article, 推荐等级 B)
  • PMID 42679821 — Oxygen-responsive bacterial glycosphingolipid links symbiont fitness and immune development in neonatal host. (Research Article, 推荐等级 B)
  • PMID 42679820 — Ratiometric transcriptional activation by protein degradation. (Research Article, 推荐等级 B)
  • PMID 42679819 — Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities. (Research Article, 推荐等级 B)
  • PMID 42648290 — Virtual Cell Challenge 2026: Benchmarking zero-shot generalization across cellular contexts. (Research Article, 推荐等级 B)
  • PMID 42617595 — Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function. (Research Article, 推荐等级 B)
  • PMID 42600612 — Polyamines buffer labile iron to suppress ferroptosis. (Research Article, 推荐等级 B)
  • PMID 42551425 — Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis. (Research Article, 推荐等级 B)
  • PMID 42551424 — Targeting peripheral 5-HT 2A R enhances antitumor immunity in colorectal cancer. (Research Article, 推荐等级 B)
  • PMID 42556334 — Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer. (Research Article, 推荐等级 B)
  • PMID 42537647 — Spatial atlas of the human brain vasculature reveals specialized cell ensembles. (Research Article, 推荐等级 B)
  • PMID 42532044 — Dietary arginine drives codon-dependent MHC class I translation and improves immunity in colon tumorigenesis and respiratory viral infection. (Research Article, 推荐等级 B)
  • PMID 42532043 — Basement membrane turnover controls cell shape. (Research Article, 推荐等级 B)
  • PMID 42508404 — Advancing cancer detection and treatment using longitudinal routine clinical data. (Research Article, 推荐等级 B)
  • PMID 42486084 — The intrinsic cardiac nervous system is essential for cardiac function and survival. (Research Article, 推荐等级 B)
  • PMID 42480527 — Localized PD-1 CAR T therapy reprograms neuroinflammation. (Research Article, 推荐等级 B)
  • PMID 42462711 — Boron-bridged GIPCs stabilize cell wall anchoring and PIN polar domains. (Research Article, 推荐等级 B)
  • PMID 42462710 — Whole-transcriptome-scale isoform-resolved spatial imaging of single cells in tissues. (Research Article, 推荐等级 B)
  • PMID 42385704 — Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs. (Research Article, 推荐等级 B)
  • PMID 42385701 — Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis. (Research Article, 推荐等级 B)
  • PMID 42341759 — Reconstituting human primitive streak formation through extra-embryonic cell coordination. (Research Article, 推荐等级 C)

三、逐篇文献解读

以下精选 20 篇 A 级高优先级文献进行详细解读。其余纳入文献的核心信息已列于上文总表。

文献 1

英文题目： GPCR antagonism via rewiring of receptor trafficking and degradation.

中文题目： 通过重编程受体转运与降解实现 GPCR 拮抗

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Rhee Kaitlin, Shue Lawrence, Adachi Akimasa, Sun Pengwei, Osei-Owusu James et al. DOI： 10.1038/s41586-026-11088-0 PMID： 42816619官方链接： https://www.nature.com/articles/s41586-026-11088-0 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816619/ OA 状态： 可能开放获取（PMC ID: PMC13632652）研究领域： 免疫学, 肿瘤学, 细胞生物学, 微生物/病毒, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

G-protein-coupled receptors (GPCRs) represent one of the most important yet incompletely addressed classes of therapeutic targets1. Here we report a strategy for functional GPCR antagonism through bispecific antibody-mediated endocytosis and lysosomal degradation. GPCR-TfR1 targeting chimeras (GTACs) achieve potent and selective downregulation of multiple GPCRs, including BILF1, RXFP1 and CCR6-viral, cancer and immune targets that have been difficult to drug2-4. GTACs lead to complete inhibition of receptor signalling, including constitutive signalling, with more than one to two orders of magnitude greater potency than conventional antibody antagonists. Using protein engineering and multicolour live-cell imaging, we establish a context-dependent degrader design and explain the cellular mechanisms, with broad relevance for degrader technology. The GTAC platform establishes induced endocytosis and rewiring protein trafficking as a model for therapeutic GPCR modulation.

2. 摘要中文翻译

G 蛋白偶联受体（GPCR）是最重要但尚未充分开发的药物靶点类别之一。本研究报道了一种通过双特异性抗体介导的内吞和溶酶体降解实现功能性 GPCR 拮抗的策略。GPCR-TfR1 靶向嵌合体（GTACs）可强效且选择性地下调多种 GPCR，包括 BILF1、RXFP1 和 CCR6——这些分别是病毒、癌症和免疫靶点，长期以来难以成药。GTACs 可完全抑制受体信号（包括组成型信号），其效力比传统抗体拮抗剂高 1-2 个数量级。利用蛋白工程和多色活细胞成像，研究建立了情境依赖性降解器设计，并阐明了细胞机制，对降解器技术具有广泛意义。GTAC 平台确立了诱导内吞和重编程蛋白转运作为治疗性 GPCR 调控的新范式。

3. 摘要层面解读

  • 研究对象： G 蛋白偶联受体（GPCR）、双特异性抗体、TfR1、BILF1、RXFP1、CCR6
  • 核心科学问题： 如何通过非传统拮抗机制（降解而非阻断）实现对难以成药 GPCR 的有效调控？
  • 主要方法： 设计 GPCR-TfR1 靶向嵌合体（GTACs）；蛋白工程优化；多色活细胞成像；受体信号检测；溶酶体降解分析。
  • 主要发现： GTACs 通过双特异性抗体同时结合 GPCR 和转铁蛋白受体 TfR1，诱导 GPCR 内吞并靶向溶酶体降解；对 BILF1、RXFP1、CCR6 等难成药靶点实现强效下调和信号完全抑制。
  • 方向归属： 免疫学, 肿瘤学, 细胞生物学, 微生物/病毒, 药物研发, 蛋白质科学
  • 值得关注的原因： 为难成药 GPCR 靶点提供了全新的降解策略，超越了传统小分子和抗体拮抗剂的局限，具有广泛的肿瘤、免疫和病毒感染治疗潜力。

4. 全文精读分析

未进行全文分析，原因：PMC ID 存在，但需进一步核验 OA 可访问性及获取全文。

5. 一句话评价

GTAC 平台通过重编程受体转运实现 GPCR 功能拮抗，为难成药靶点开辟了治疗性蛋白降解新路径。

文献 2

英文题目： Dynamic protrusions mediate crawling motility in Asgard archaea.

中文题目： 动态突起介导阿斯加德古菌的爬行运动

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Radler Philipp, Viehboeck Tobias, Luo Zhen-Hao, Maslać Nevena, Schmidt Katharina et al. DOI： 10.1038/s41586-026-11063-9 PMID： 42816618官方链接： https://www.nature.com/articles/s41586-026-11063-9 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816618/ OA 状态： 非 OA / 需订阅访问研究领域： 细胞生物学, 药物研发, 人工智能, 蛋白质科学 推荐等级： A

1. 原文摘要

Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion and spatially organized signalling pathways1,2. Asgard archaea, which are considered the closest known prokaryotic relatives of eukaryotes, potentially encode these functions within their large set of 'eukaryotic signature proteins'3-6. The few cultivated members show a complex cell morphology, consisting of a central cell body from which several protrusions extend, filled with an actin-based cytoskeleton7,8. Here, live-cell microscopy of two organisms of the Lokiarchaea and Hodarchaea lineages7,9 showed that they dynamically and greatly change their cell shape on a minute time scale and grow and retract their extensive protrusions with a speed of 1.5-4.8 µm min-1, respectively. After adhering to a glass surface, cells use their protrusions to undergo active crawling motion. In the presence of selected actin inhibitors, however, the observed dynamics were arrested, suggesting a central role of actin in these processes. The observed cellular plasticity and motility are unique features among prokaryotes and might have been crucial for the emergence of the first eukaryotic cells that are thought to have formed through the association of a member of the Asgard archaea and an α-proteobacterium, the ancestor of mitochondria.

2. 摘要中文翻译

爬行运动是真核细胞的标志，需要动态肌动蛋白细胞骨架、受调控的粘附和空间组织的信号通路。阿斯加德古菌被认为是已知最接近真核生物的原核生物，其大量“真核特征蛋白”可能编码这些功能。少数可培养的阿斯加德古菌表现出复杂的细胞形态：中央细胞体延伸出多个充满肌动蛋白细胞骨架的突起。本研究对 Lokiarchaea 和 Hodarchaea 两个类群的两种生物进行活细胞显微观察，发现它们能在分钟时间尺度上动态大幅改变细胞形状，突起生长和收缩速度分别为 1.5-4.8 µm/min。粘附于玻璃表面后，细胞利用突起进行主动爬行运动。然而，在特定肌动蛋白抑制剂存在下，这些动态被阻断，提示肌动蛋白在此过程中发挥核心作用。观察到的细胞可塑性和运动性在古菌中独一无二，可能对首个真核细胞的产生至关重要——据认为真核细胞由阿斯加德古菌与 α-变形菌（线粒体祖先）共生形成。

3. 摘要层面解读

  • 研究对象： 阿斯加德古菌（Lokiarchaea、Hodarchaea）、肌动蛋白细胞骨架、细胞突起、爬行运动
  • 核心科学问题： 阿斯加德古菌是否具有由肌动蛋白驱动的真核样细胞运动能力，这对真核细胞起源有何启示？
  • 主要方法： 活细胞显微镜观察；肌动蛋白抑制剂处理；细胞形态与运动速度定量分析。
  • 主要发现： 阿斯加德古菌能形成动态肌动蛋白突起并在固体表面爬行；肌动蛋白抑制剂阻断运动；这是原核生物中独有的真核样运动特征。
  • 方向归属： 细胞生物学, 药物研发, 人工智能, 蛋白质科学
  • 值得关注的原因： 为理解真核细胞起源和肌动蛋白细胞骨架的早期演化提供了直接细胞生物学证据。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

在阿斯加德古菌中观察到肌动蛋白驱动的真核样爬行运动，为真核细胞演化提供了关键线索。

文献 3

英文题目： γδ T cell receptor dependencies define a unique immunosurveillance modality.

中文题目： γδ T 细胞受体依赖性定义了一种独特的免疫监视模式

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Veland Nicolas, Garcia-Cassani Bethania, Zarco-Cuadrillero Ángela, Mavrigiannaki Annamaria, Natalini Ambra et al. DOI： 10.1038/s41586-026-11076-4 PMID： 42816614官方链接： https://www.nature.com/articles/s41586-026-11076-4 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816614/ OA 状态： 非 OA / 需订阅访问研究领域： 免疫学, 遗传学与基因组学, 人工智能 推荐等级： A

1. 原文摘要

γδ T cells are one of three lymphocyte lineages that utilize gene rearrangement to diversify their antigen receptors. Nonetheless, the cells' classification has remained uncertain, complicating our ability to understand the basis for their evolutionary conservation. Whereas many γδ T cells display hallmarks of adaptive immunity, others, including those in barrier tissues, make rapid, reportedly T cell receptor-independent responses that phenocopy innate immune cells1. Here we address this paradox and show that the phenotypes of tissue-intrinsic γδ T cells, including their rapid, innate-like responsiveness to tissue stress and carcinogenesis, acutely depend on the γδ T cell receptor (TCRγδ). Those dependencies emphasize the unique biology of γδ T cells and of the immunosurveillance modalities they mediate, with their clinical deployment evidently requiring environments conducive to TCRγδ signalling.

2. 摘要中文翻译

γδ T 细胞是利用基因重排来多样化其抗原受体的三种淋巴细胞谱系之一。然而，该细胞的分类长期不明，阻碍了我们理解其进化保守性的基础。许多 γδ T 细胞具有适应性免疫特征，但其他 γδ T 细胞（包括屏障组织中的细胞）能快速做出 reportedly T 细胞受体非依赖的反应，表型模拟先天免疫细胞。本研究解决了这一悖论，证明组织固有 γδ T 细胞的表型，包括其对组织应激和癌变的快速先天样反应，急性依赖于 γδ T 细胞受体（TCRγδ）。这些依赖性强调了 γδ T 细胞及其介导的免疫监视模式的独特生物学，其临床应用显然需要有利于 TCRγδ 信号传导的环境。

3. 摘要层面解读

  • 研究对象： γδ T 细胞、TCRγδ、组织免疫监视、屏障组织、癌症免疫
  • 核心科学问题： 组织固有 γδ T 细胞的快速免疫监视反应是否依赖 TCRγδ，这对 γδ T 细胞分类和临床应用有何意义？
  • 主要方法： 遗传学模型；γδ T 细胞受体信号阻断；组织应激与肿瘤模型；表型与功能分析。
  • 主要发现： 组织固有 γδ T 细胞的快速先天样反应急性依赖 TCRγδ；γδ T 细胞具有区别于 αβ T 细胞和先天免疫细胞的独特生物学。
  • 方向归属： 免疫学, 遗传学与基因组学, 人工智能
  • 值得关注的原因： 重新定义了 γδ T 细胞的免疫学地位，为开发 γδ T 细胞癌症免疫疗法提供了重要理论依据。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

揭示 γδ T 细胞免疫监视的 TCRγδ 依赖性，为理解其独特生物学和临床转化提供了新框架。

文献 4

英文题目： Prion-like transmission of human tau strains in the mouse brain.

中文题目： 人源 tau 毒株在小鼠脑中的朊病毒样传播

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Lövestam Sofia, Shimozawa Aki, Tarutani Airi, Ohtani Reiko, Masuda-Suzukake Masami et al. DOI： 10.1038/s41586-026-11061-x PMID： 42816607官方链接： https://www.nature.com/articles/s41586-026-11061-x PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816607/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 遗传学与基因组学, 结构生物学, 蛋白质科学 推荐等级： A

1. 原文摘要

Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding1. Distinct conformations of amyloid filaments may provide the physical basis for the strains that lead to different diseases2. However, a central pillar of the prion hypothesis, that strains retain their structural identity upon transmission, has not been demonstrated. Here we show that the injection of tau filaments from the brains of individuals with Alzheimer's disease or corticobasal degeneration into the brains of wild-type mice leads to the seeded assembly of amyloid filaments made of mouse tau with the same structures as those of the seeds. Thus, we show that, similar to prion strains, tau filaments propagate through templated seeding, and that the mouse is a suitable model to study the molecular mechanisms by which distinct tau folds drive disease-specific pathology in the brain.

2. 摘要中文翻译

大多数神经退行性疾病被认为通过朊病毒样机制在大脑中传播，其中丝状蛋白聚集体通过模板播种自我增殖。淀粉样丝的不同构象可能构成导致不同疾病的毒株的物理基础。然而，朊病毒假说的核心支柱——毒株在传播过程中保持其结构同一性——尚未得到证实。本研究显示，将阿尔茨海默病或皮质基底节变性患者脑中的 tau 丝注射到野生型小鼠脑中，会导致由小鼠 tau 组成的淀粉样丝发生播种组装，且其结构与种子 tau 丝相同。因此，我们证明 tau 丝与朊病毒毒株类似，通过模板播种传播，并且小鼠是研究不同 tau 折叠如何驱动脑中疾病特异性病理的合适模型。

3. 摘要层面解读

  • 研究对象： tau 蛋白、朊病毒样传播、阿尔茨海默病、皮质基底节变性、小鼠模型
  • 核心科学问题： 人源 tau 毒株能否在野生型小鼠脑中保持其结构同一性并通过模板播种传播？
  • 主要方法： 人脑 tau 丝提取与注射；野生型小鼠脑内接种；电子显微镜/冷冻电镜结构分析；病理播种评估。
  • 主要发现： 人源 tau 丝可在小鼠脑中诱导具有相同结构的小鼠 tau 丝组装；证实了 tau 毒株的结构保守性传播。
  • 方向归属： 神经科学, 遗传学与基因组学, 结构生物学, 蛋白质科学
  • 值得关注的原因： 为 tau 病理传播机制和神经退行性疾病毒株研究提供了关键实验证据，验证了小鼠模型的适用性。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

直接证明了 tau 毒株的朊病毒样结构保守传播，是神经退行性疾病机制研究的重要进展。

文献 5

英文题目： Function-preserving watermarking of AI-generated proteins.

中文题目： 保留功能的 AI 生成蛋白质水印技术

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Stutz David, Cowen-Rivers Alexander I, Ortiz-Jimenez Guillermo, Ratcliff Jeremy, Zambaldi Vinicius et al. DOI： 10.1038/s41586-026-10965-y PMID： 42816606官方链接： https://www.nature.com/articles/s41586-026-10965-y PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816606/ OA 状态： 非 OA / 需订阅访问研究领域： 遗传学与基因组学, 结构生物学, 药物研发, 人工智能, 蛋白质科学 推荐等级： A

1. 原文摘要

Generative artificial intelligence (AI) models are revolutionizing biology, with tools such as AlphaFold 3 and protein design models accelerating breakthroughs in protein structure prediction and the creation of new functional proteins1. Tracking and establishing the provenance of AI-generated protein sequences and structures is becoming increasingly important to tackle a range of emerging challenges, including biosecurity and concerns about information veracity2-4. Here we introduce SynthIDBio, a family of methods for watermarking protein sequences and structures to establish the provenance of those generated with AI. SynthIDBio-sequence actively embeds a watermark into protein sequences while preserving function. We demonstrate this by creating watermarked, functional designed protein binders with binding affinity comparable with non-watermarked counterparts and near-perfect watermark detection accuracy. Furthermore, SynthIDBio-structure, a fine-tuned AlphaFold3 model, embeds an imperceptible watermark into biomolecular structures. Our work is a proof-of-concept that function-preserving biological watermarking is feasible, introducing a potential tool for provenance in the rapidly expanding era of AI-driven biological engineering.

2. 摘要中文翻译

生成式人工智能模型正在革新生物学，AlphaFold 3 和蛋白质设计模型等工具加速了蛋白质结构预测和新功能蛋白创造的突破。追踪和确定 AI 生成蛋白质序列及结构的来源日益重要，以应对生物安全和信息真实性等新挑战。本研究介绍 SynthIDBio，一套用于给蛋白质序列和结构加水印以建立 AI 生成物来源的方法。SynthIDBio-sequence 可在保留功能的同时主动将水印嵌入蛋白质序列；研究通过创建带有水印的功能性设计蛋白结合剂证明了这一点，其结合亲和力与非水印对应物相当，且水印检测准确率接近完美。此外，SynthIDBio-structure 是一个经过微调的 AlphaFold3 模型，可将不可察觉的水印嵌入生物分子结构中。该研究证明保留功能的生物水印是可行的，为快速发展的 AI 驱动生物工程时代提供了一种潜在来源追踪工具。

3. 摘要层面解读

  • 研究对象： AI 生成蛋白质、水印技术、SynthIDBio、AlphaFold3、生物安全
  • 核心科学问题： 如何在不破坏蛋白质功能的前提下，为 AI 生成的蛋白质序列和结构嵌入可检测的水印？
  • 主要方法： 开发 SynthIDBio-sequence 和 SynthIDBio-structure；设计蛋白结合剂验证；水印检测准确性评估；AlphaFold3 微调。
  • 主要发现： SynthIDBio 可在保留功能的前提下为 AI 生成蛋白质序列和结构添加水印；水印检测准确率接近完美。
  • 方向归属： 遗传学与基因组学, 结构生物学, 药物研发, 人工智能, 蛋白质科学
  • 值得关注的原因： 为 AI 生成生物分子的来源追溯、生物安全和信息真实性提供了关键技术工具。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

SynthIDBio 为 AI 生成蛋白质提供了功能保留的水印方案，是 AI 生物工程治理的重要技术进展。

文献 6

英文题目： Written in development and lost in ageing: the grammar of cellular identity.

中文题目： 发育中书写、衰老中遗失：细胞身份的语法

期刊： Nature发表日期： 未提供文章类型： Review 作者： Yücel A Doğa, Molière Adrian, Gladyshev Vadim N DOI： 10.1038/s41586-026-10955-0 PMID： 42816559官方链接： https://www.nature.com/articles/s41586-026-10955-0 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816559/ OA 状态： 非 OA / 需订阅访问研究领域： 发育生物学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

Ageing has been described through many theoretical frameworks, yet its mechanistic basis remains unresolved. Here we propose that ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development. Extending Waddington's epigenetic landscape, development canalizes cell fates through globally coordinated chromatin programs that establish identity constraints across multiple timescales. Subsequently, these constraints can only be maintained through local mechanisms with limited fidelity. The asymmetry between high-fidelity writing and imperfect maintenance generates predictable drift that accumulates with biological time. Antagonistic chromatin pathways, particularly polycomb repressive complex 2 (PRC2)-mediated repression opposed by H3K4/36 methylation and RNA polymerase II binding, enforce identity boundaries through mutual constraint. With age, this balance erodes. Consistent with this framework, the vast majority of age-associated DNA methylation gain in somatic mitotic tissues occurs at PRC2-bound low-methylated regions, indicating that these domains function as conserved coordinates of slow-layer drift. This model explains cross-tissue ageing signatures, developmental timing-to-lifespan correlations and robustness of pan-mammalian epigenetic ageing clocks. It provides testable predictions for interventions that stabilize architecture to preserve cellular identity and function.

2. 摘要中文翻译

衰老已被多种理论框架描述，但其机制基础仍未解决。本研究提出，衰老反映了哺乳动物细胞身份的渐进式去规范化（decanalization），其驱动力是发育过程中书写的调控语法的侵蚀。延伸 Waddington 的表观遗传景观理论，发育通过全局协调的染色质程序使细胞命运规范化，在多个时间尺度上建立身份约束。随后，这些约束只能通过保真度有限的局部机制维持。高保真书写与 imperfect 维持之间的不对称性产生了可预测的漂移，并随生物时间累积。拮抗性染色质通路，特别是 PRC2 介导的抑制与 H3K4/36 甲基化及 RNA 聚合酶 II 结合的对抗，通过相互约束执行身份边界。随着年龄增长，这种平衡被侵蚀。与该框架一致，体细胞有丝裂组织中大多数年龄相关 DNA 甲基化获得发生在 PRC2 结合的低甲基化区域，提示这些结构域是慢层漂移的保守坐标。该模型解释了跨组织衰老特征、发育时序与寿命的相关性，以及哺乳动物表观遗传衰老钟的稳健性，并为稳定结构以保留细胞身份和功能的干预提供了可验证预测。

3. 摘要层面解读

  • 研究对象： 细胞身份、衰老、发育、表观遗传景观、PRC2、H3K4/36 甲基化、DNA 甲基化
  • 核心科学问题： 衰老是否可理解为发育过程中建立的细胞身份调控语法随时间侵蚀所导致的去规范化？
  • 主要方法： 理论框架构建；跨组织表观遗传数据分析；PRC2 结合区域与衰老相关 DNA 甲基化关联分析。
  • 主要发现： 衰老是细胞身份约束的渐进式侵蚀；PRC2 与 H3K4/36 甲基化/RNA Pol II 的拮抗维持身份边界；PRC2 结合低甲基化区域是跨组织衰老信号的核心。
  • 方向归属： 发育生物学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学
  • 值得关注的原因： 提出了衰老机制的统一理论框架，连接发育、表观遗传和跨物种衰老时钟，为抗衰老干预提供了新思路。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

以“细胞身份语法”视角重新解释衰老，是衰老生物学理论的系统性推进。

文献 7

英文题目： Scalable decision-making for games of imperfect information.

中文题目： 不完美信息博弈的可扩展决策

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Sokota Samuel, Vinitsky Eugene, Hu Hengyuan, Fan Zhiyuan, Kolter J Zico et al. DOI： 10.1038/s41586-026-11036-y PMID： 42816558官方链接： https://www.nature.com/articles/s41586-026-11036-y PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816558/ OA 状态： 可能开放获取（PMC ID: PMC13626944）研究领域： 遗传学与基因组学, 人工智能 推荐等级： A

1. 原文摘要

Real-world decision-making generally involves hidden information, that is, information that is unknown to one agent but possessed by another. Unfortunately, the presence of large amounts of hidden information renders established reinforcement learning and search approaches ineffective. Even with multimillion-dollar industrial research efforts1, top-human-level play at Stratego-a board wargame with hidden information on a massive scale-has remained beyond the reach of artificial intelligence (AI). Here we introduce Ataraxos, an AI for Stratego based on general techniques that we developed for both self-play reinforcement learning and test-time search under hidden information. Ataraxos defeated the most decorated human Stratego player of all time by a large margin-achieving, to our knowledge, the first superhuman result in the game's history-while consuming orders of magnitude less compute and data than previous efforts. Using the same techniques, we built a superhuman AI for Barrage Stratego and state-of-the-art AIs for Hanabi and dou dizhu, all with low cost and high sample efficiency. The success of this approach across adversarial, cooperative and team games establishes a design pattern for reinforcement learning and search that is effective under large amounts of hidden information, a longstanding desideratum of the field of strategic decision-making.

2. 摘要中文翻译

现实世界决策通常涉及隐藏信息，即一个智能体未知而另一个智能体拥有的信息。大量隐藏信息使现有的强化学习和搜索方法失效。即便投入数百万美元的工业研究，Stratego——一种大规模隐藏信息的棋盘战争游戏——的顶级人类水平对弈对 AI 而言仍遥不可及。本研究介绍 Ataraxos，一个用于 Stratego 的 AI，基于我们为隐藏信息下的自博弈强化学习和测试时搜索开发的通用技术。Ataraxos 以大幅优势击败了历史上最负盛名的人类 Stratego 玩家，据我们所知取得了该游戏史上首个超人类结果，同时消耗的算力和数据比此前努力少几个数量级。使用相同技术，研究团队还为 Barrage Stratego 构建了超人类 AI，并为 Hanabi 和斗地主（dou dizhu）构建了最先进 AI，均具有低成本和高样本效率。该方法在对抗、合作和团队游戏中的成功，确立了在大量隐藏信息下有效的强化学习与搜索设计模式，这是战略决策领域长期追求的目标。

3. 摘要层面解读

  • 研究对象： 不完美信息博弈、Stratego、强化学习、搜索算法、Ataraxos AI
  • 核心科学问题： 如何为大量隐藏信息下的博弈构建可扩展、样本高效的超人类决策 AI？
  • 主要方法： 开发自博弈强化学习技术；测试时搜索；多游戏验证（Stratego、Barrage Stratego、Hanabi、斗地主）。
  • 主要发现： Ataraxos 在 Stratego 上首次达到超人类水平；同一框架可迁移至其他不完美信息博弈，且算力和数据成本显著降低。
  • 方向归属： 遗传学与基因组学, 人工智能
  • 值得关注的原因： 为处理隐藏信息的决策 AI 提供了通用框架，对博弈论、强化学习和现实世界战略决策具有广泛意义。

4. 全文精读分析

未进行全文分析，原因：PMC ID 存在，但需进一步核验 OA 可访问性及获取全文。

5. 一句话评价

Ataraxos 在不完美信息博弈中首次实现超人类表现，是战略决策 AI 的重要里程碑。

文献 8

英文题目： Single-cell atlas of transcriptomic vulnerability across brain disorders.

中文题目： 跨脑部疾病的转录组脆弱性单细胞图谱

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Lee Donghoon, Koutrouli Mikaela, Masse Nicolas Y, Hoffman Gabriel E, Kinrot Seon et al. DOI： 10.1038/s41586-025-09573-z PMID： 42778699官方链接： https://www.nature.com/articles/s41586-025-09573-z PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42778699/ OA 状态： 可能开放获取（PMC ID: PMC13600946）研究领域： 神经科学, 免疫学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学, 生物技术 推荐等级： A

1. 原文摘要

Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2. Here, to gain deeper insights into the aetiology of different brain diseases, we used specimens from 1,494 unique donors to generate a population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex, comprising over 6.3 million individual nuclei. The cohort includes neurotypical controls, as well as donors affected by eight common and complex brain disorders: Alzheimer's disease (AD), diffuse Lewy body disease (DLBD), vascular dementia (Vas), Parkinson's disease (PD), tauopathy, frontotemporal dementia, schizophrenia, and bipolar disorder. We show that interindividual variation accounts for a substantial portion of gene expression variation. By comparing transcriptomic variation across diseases, we reveal universal signatures enriched in basic cellular functions such as mRNA processing and protein localization. After discounting these cross-disease signatures, we show stronger genetic and transcriptomic concordance among AD, DLBD, Vas and PD. Furthermore, we characterize transcriptomic variation among different AD phenotypes, distinct from those observed in healthy ageing, revealing a reduction in neuronal abundance in individuals with more severe AD, coupled with an increase in immune and vascular cell populations. Exploring the neuropsychiatric symptoms (NPSs) that frequently accompany AD, we find an increased abundance of deep-layer excitatory neurons associated with a broad range of NPSs. By constructing transcriptome trajectories that capture AD progression, we implicate cell-type-specific responses in the early and late stages of AD. Our disease atlas provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorders, shedding light on shared and distinct processes involving the neurological-immune-vascular systems, and identifying potential targets for therapeutic intervention.

2. 摘要中文翻译

神经退行性和神经精神疾病造成巨大的社会和公共卫生负担，但其分子机制仍知之甚少。本研究利用 1,494 名独特捐赠者的标本，构建了人类背外侧前额叶皮层的群体规模单细胞转录组图谱，包含超过 630 万个细胞核。队列包括神经典型对照以及八种常见复杂脑疾病患者：阿尔茨海默病、弥漫性路易体病、血管性痴呆、帕金森病、tau 病、额颞叶痴呆、精神分裂症和双相情感障碍。研究显示个体间变异占基因表达变异的很大一部分。通过跨疾病比较转录组变异，研究揭示了在 mRNA 加工和蛋白质定位等基本细胞功能中富集的普遍特征。排除这些跨疾病特征后，阿尔茨海默病、弥漫性路易体病、血管性痴呆和帕金森病显示出更强的遗传和转录组一致性。此外，研究表征了不同阿尔茨海默病表型间区别于健康衰老的转录组变异，揭示严重 AD 患者神经元丰度降低，同时免疫和血管细胞群体增加。探索 AD 常见的神经精神症状，研究发现深层兴奋性神经元丰度增加与广泛的神经精神症状相关。通过构建捕捉 AD 进展的转录组轨迹，研究揭示了 AD 早期和晚期的细胞类型特异性反应。该疾病图谱为神经退行性和神经精神疾病的转录组景观提供了全景视角，阐明了共享和特异的疾病过程。

3. 摘要层面解读

  • 研究对象： 人类背外侧前额叶皮层、单细胞转录组、八种脑疾病、阿尔茨海默病、帕金森病、精神分裂症
  • 核心科学问题： 不同神经退行性和神经精神疾病在单细胞转录组水平上有哪些共享和特异的脆弱性特征？
  • 主要方法： 1,494 名捐赠者脑组织单细胞核 RNA 测序；跨疾病转录组比较；遗传共定位分析；细胞类型特异性轨迹建模。
  • 主要发现： 跨疾病存在普遍转录组特征；AD 与 DLBD/Vas/PD 有较高一致性；严重 AD 表现为神经元减少、免疫/血管细胞增加；深层兴奋性神经元与神经精神症状相关。
  • 方向归属： 神经科学, 免疫学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学, 生物技术
  • 值得关注的原因： 提供了迄今为止最大规模的脑疾病单细胞图谱资源，为解析复杂脑疾病的共同机制和开发治疗靶点奠定基础。

4. 全文精读分析

未进行全文分析，原因：PMC ID 存在，但需进一步核验 OA 可访问性及获取全文。

5. 一句话评价

该图谱以群体规模单细胞数据系统描绘了脑疾病的转录组脆弱性，是神经精神疾病研究的重要数据资源。

文献 9

英文题目： TRAM promotes Toll-like-receptor-free myddosome signal transduction.

中文题目： TRAM 促进不依赖 Toll 样受体的 myddosome 信号转导

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Fisch Daniel, Ohri Vaani, Anastasakou Eleni, Wesemann Lucia J, Choi Joon H et al. DOI： 10.1038/s41586-026-11052-y PMID： 42778610官方链接： https://www.nature.com/articles/s41586-026-11052-y PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42778610/ OA 状态： 非 OA / 需订阅访问研究领域： 免疫学, 细胞生物学, 遗传学与基因组学, 人工智能, 蛋白质科学 推荐等级： A

1. 原文摘要

In the Toll-like receptor (TLR) signal transduction pathways, activated receptors are present for mere minutes within the initial, membrane-proximal signalling complexes called proto-myddosomes1. Proto-myddosomes are rapidly released from TLRs to self-assemble (that is, mature) into enzyme-rich, cytosolic supramolecular organizing centres called myddosomes2-4. Myddosomes induce hours-long inflammatory gene expression5-10. The mechanism controlling proto-myddosome release and its effect on signal transduction are undefined. Here we identify factors that regulate the maturation process of proto-myddosomes into receptor-free cytosolic myddosomes11. Through a genetic screen in macrophages, we identify TRAM, which was previously described to control MyD88-independent TLR signalling, as a regulator of myddosome assembly. Using biochemistry, live-cell imaging and activity reconstitution with recombinant proteins, we show that the plasma-membrane-associated adapter TIRAP seeds proto-myddosomes12,13, after which TRAM dissociates MyD88 from the TLR-TIRAP complex to enable myddosome maturation and downstream signal transduction14-19. In the absence of TRAM, MyD88 cannot dissociate from the TLR-TIRAP complex, resulting in abnormal and unstable MyD88 interactions with downstream signalling enzymes. These findings enabled us to identify TRAM-dependent long-lasting myddosome activities as the determinant of two TLR pathway hallmarks: hours-long NF-κB activation20-24 and secondary response gene expression25-27. Chemical dissociation of cytosolic myddosomes disrupted existing inflammatory activities of TLR-stimulated cells in vitro and in vivo. Collectively, this work establishes TRAM as a regulator of myddosome maturation and signalling, providing the molecular basis for receptor-free signal transduction.

2. 摘要中文翻译

在 Toll 样受体（TLR）信号通路中，活化受体在最初的膜近端信号复合物（称为原 myddosomes）中仅存在数分钟。原 myddosomes 迅速从 TLR 释放并自我组装（成熟）为富含酶的胞质超分子组织中心——myddosomes，诱导持续数小时的炎症基因表达。控制原 myddosome 释放及其对信号转导影响的机制尚不清楚。本研究鉴定了调控原 myddosomes 成熟为不依赖受体的胞质 myddosomes 的因子。通过在巨噬细胞中进行遗传筛选，研究确定了 TRAM——此前被认为控制 MyD88 非依赖性 TLR 信号——是 myddosome 组装的调控因子。利用生物化学、活细胞成像和重组蛋白活性重构，研究显示膜相关接头蛋白 TIRAP 播种原 myddosomes，随后 TRAM 将 MyD88 从 TLR-TIRAP 复合物中解离，使 myddosome 成熟和下游信号转导得以进行。缺乏 TRAM 时，MyD88 无法从 TLR-TIRAP 复合物解离，导致 MyD88 与下游信号酶之间异常且不稳定的相互作用。这些发现使研究者鉴定出 TRAM 依赖的长效 myddosome 活性是 TLR 通路两个标志性特征的决定因素：持续数小时的 NF-κB 激活和二次反应基因表达。化学解离胞质 myddosomes 可破坏 TLR 刺激细胞在体外和体内的现有炎症活性。总之，本研究确立 TRAM 是 myddosome 成熟和信号转导的调控因子，为不依赖受体的信号转导提供了分子基础。

3. 摘要层面解读

  • 研究对象： Toll 样受体（TLR）、TRAM、TIRAP、MyD88、myddosome、炎症信号
  • 核心科学问题： TRAM 如何调控 myddosome 从膜近端原 myddosome 到胞质成熟 myddosome 的转变，从而影响 TLR 信号？
  • 主要方法： 巨噬细胞遗传筛选；生物化学分析；活细胞成像；重组蛋白活性重构；体内炎症模型。
  • 主要发现： TRAM 通过将 MyD88 从 TLR-TIRAP 复合物解离促进 myddosome 成熟；TRAM 依赖的长效 myddosome 活性决定持续 NF-κB 激活和二次反应基因表达。
  • 方向归属： 免疫学, 细胞生物学, 遗传学与基因组学, 人工智能, 蛋白质科学
  • 值得关注的原因： 揭示了 TLR 信号从受体依赖阶段向受体不依赖阶段转变的关键分子机制，为炎症性疾病治疗提供了新靶点。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

TRAM 调控 myddosome 成熟机制的发现，为理解 TLR 信号的持续性和炎症调控开辟了新视角。

文献 10

英文题目： A design approach for bitopic kinase inhibitors.

中文题目： 双位点激酶抑制剂的设计方法

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Stevenson Jack W, Lou Kevin, Reynolds Joshua A, Outhwaite Ian R, Huang Kenneth et al. DOI： 10.1038/s41586-026-11056-8 PMID： 42778601官方链接： https://www.nature.com/articles/s41586-026-11056-8 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42778601/ OA 状态： 非 OA / 需订阅访问研究领域： 肿瘤学, 遗传学与基因组学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

Traditional kinase inhibitors face a trade-off between potency and selectivity because their affinity depends on limited molecular interactions in a single highly conserved binding site. Bitopic inhibitors overcome this limitation by engaging multiple sites on the same target1. Here, using ABL1 and EGFR as model kinases, we systematically explore the bitopic-specific design parameters of ligand choice, linkage vector and linker length and show that they affect potency through inter-ligand cooperativity and linker entropy. We apply this approach to address an unmet clinical need: existing inhibitors of ABL1, an important target in BCR::ABL1-driven leukaemias, are constrained by resistance mutations and off-target effects2. The third-generation inhibitor ponatinib overcomes many resistance mutations, but cardiovascular toxicity limits its clinical use3. We design a bitopic ABL1 inhibitor, PonatiLink-2, that maintains or surpasses the potency of ponatinib against resistance mutants. Moreover, it has an enhanced therapeutic window in vitro and in vivo, which enables increased dosing without apparent toxicity. PonatiLink-2 outperforms clinically relevant treatments in mouse models of BCR::ABL1-driven cancer, both in combination with dasatinib against wild-type BCR::ABL1 and as a single agent against ponatinib-resistant disease. These findings indicate that the bitopic design approach is a promising strategy for developing potent, well-tolerated clinical inhibitors of ABL1 and other targets.

2. 摘要中文翻译

传统激酶抑制剂面临效力和选择性之间的权衡，因为其亲和力依赖于单个高度保守结合位点中的有限分子相互作用。双位点抑制剂通过同时结合同一靶点的多个位点克服了此限制。本研究以 ABL1 和 EGFR 为模型激酶，系统探索了双位点特异性设计参数——配体选择、连接向量和连接子长度，并证明它们通过配体间协同性和连接子熵影响效力。研究将这一方法应用于未满足的临床需求：ABL1 是 BCR::ABL1 驱动白血病的重要靶点，现有抑制剂受耐药突变和脱靶效应限制。第三代抑制剂 ponatinib 克服了许多耐药突变，但心血管毒性限制了其临床使用。研究团队设计了双位点 ABL1 抑制剂 PonatiLink-2，对耐药突变保持或超越 ponatinib 的效力，且在体外和体内具有更宽的治疗窗，可在无明显毒性情况下提高剂量。在 BCR::ABL1 驱动癌症小鼠模型中，PonatiLink-2 无论是与 dasatinib 联用治疗野生型 BCR::ABL1，还是作为单药治疗 ponatinib 耐药疾病，均优于临床相关治疗方案。这些发现表明双位点设计方法是开发 ABL1 及其他靶点强效、耐受性良好临床抑制剂的有前景策略。

3. 摘要层面解读

  • 研究对象： ABL1、EGFR、双位点激酶抑制剂、PonatiLink-2、BCR::ABL1 白血病
  • 核心科学问题： 如何通过双位点结合策略同时提升激酶抑制剂的效力和选择性，并克服耐药突变？
  • 主要方法： 系统优化配体、连接向量和连接子长度；激酶抑制活性检测；耐药突变细胞系评估；小鼠肿瘤模型治疗实验。
  • 主要发现： 双位点设计通过配体间协同性增强效力；PonatiLink-2 对 ABL1 耐药突变保持高效力，且治疗窗优于 ponatinib。
  • 方向归属： 肿瘤学, 遗传学与基因组学, 药物研发, 蛋白质科学
  • 值得关注的原因： 为激酶抑制剂设计提供了新范式，有望克服肿瘤靶向治疗中的耐药和毒性问题。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

双位点激酶抑制剂设计方法为开发更安全、更有效的抗癌药物提供了系统策略。

文献 11

英文题目： Lsp2 links early-life diet to adult translation and lifespan in Drosophila.

中文题目： Lsp2 将果蝇早期饮食与成体翻译和寿命联系起来

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Kosakamoto Hina, Okada Rina, Barker Clive S, Isomura-Matoba Ayako, Seita Jun et al. DOI： 10.1038/s41586-026-11031-3 PMID： 42778590官方链接： https://www.nature.com/articles/s41586-026-11031-3 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42778590/ OA 状态： 非 OA / 需订阅访问研究领域： 发育生物学, 遗传学与基因组学, 蛋白质科学 推荐等级： A

1. 原文摘要

Nearly a century ago, restricting diet during early-life periods was suggested to extend lifespan in rats and in Daphnia1,2. The effect of juvenile diet on adult physiology and lifespan has subsequently been described in other model organisms, including fruit flies3-5 and mice6-8; however, its mechanism remains poorly understood. Here, using Drosophila as a model, we show that restricting protein intake during the larval stage (early-life protein restriction; ePR) promotes adult lifespan by reducing the levels of storage proteins. Using stable-isotope tracing, we show that dietary amino acids obtained in the larval stage are retained into early adulthood, and are incorporated into ribosomal proteins in particular. This is mediated by larval serum protein 2 (Lsp2), a major storage protein, the expression of which is durably downregulated by ePR in the early adult stage. Genetic silencing of Lsp2 phenocopies ePR, attenuating ribosomal-protein abundance and translational activity in early adulthood, and extending lifespan. Restricting specific amino acids that are especially enriched in these storage proteins, such as phenylalanine and tyrosine, is sufficient to decrease the levels of early-life Lsp2 and promote longevity. These findings identify Lsp2 as a molecular carrier of nutritional history across developmental transitions, linking juvenile nutritional status to adult translational capacity and lifespan. Our study uncovers a previously unrecognized mechanism of nutritional memory that links early-life diet to lifelong organismal health.

2. 摘要中文翻译

近一个世纪前，限制早期饮食被认为可延长大鼠和水蚤的寿命。青少年饮食对成体生理和寿命的影响随后在果蝇和小鼠等模式生物中被描述，但其机制仍不清楚。本研究以果蝇为模型，证明在幼虫期限制蛋白质摄入（早期生命蛋白质限制；ePR）通过降低储存蛋白水平促进成体寿命。利用稳定同位素示踪，研究显示幼虫期获得的膳食氨基酸被保留到成年早期，并特别掺入核糖体蛋白。这一过程由幼虫血清蛋白 2（Lsp2，一种主要储存蛋白）介导，其表达在成年早期被 ePR 持久下调。Lsp2 的基因沉默可模拟 ePR，减弱成年早期的核糖体蛋白丰度和翻译活性，并延长寿命。限制富含于这些储存蛋白中的特定氨基酸（如苯丙氨酸和酪氨酸）足以降低早期生命 Lsp2 水平并促进长寿。这些发现将 Lsp2 鉴定为跨发育阶段传递营养历史的分子载体，将幼年营养状态与成体翻译能力和寿命联系起来。研究揭示了一种此前未被认识的营养记忆机制，将早期饮食与终身机体健康联系起来。

3. 摘要层面解读

  • 研究对象： 果蝇、早期蛋白质限制、Lsp2 储存蛋白、核糖体蛋白、寿命、翻译调控
  • 核心科学问题： 早期饮食限制如何通过储存蛋白 Lsp2 影响成体翻译和寿命？
  • 主要方法： 果蝇饮食限制模型；稳定同位素示踪；Lsp2 基因沉默；寿命和翻译活性测定；特定氨基酸限制实验。
  • 主要发现： ePR 降低 Lsp2 储存蛋白，减少成年早期核糖体蛋白和翻译活性，从而延长寿命；苯丙氨酸和酪氨酸限制可复制此效应。
  • 方向归属： 发育生物学, 遗传学与基因组学, 蛋白质科学
  • 值得关注的原因： 揭示了营养记忆跨发育阶段调控寿命的分子机制，为饮食干预和衰老研究提供了新靶点。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

Lsp2 作为营养记忆载体的发现，连接了早期饮食、成体翻译和寿命调控。

文献 12

英文题目： Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes.

中文题目： 通过未活化烯烃的生物催化氮杂环丙烷化合成手性噁唑烷酮

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Li Zi-Qi, Hanley Deirdre, Zhang Yu, Xie Pei-Pei, Wu Sophia J et al. DOI： 10.1038/s41586-026-11169-0 PMID： 42778177官方链接： https://www.nature.com/articles/s41586-026-11169-0 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42778177/ OA 状态： 非 OA / 需订阅访问研究领域： 遗传学与基因组学, 微生物/病毒, 药物研发, 人工智能, 蛋白质科学 推荐等级： A

1. 原文摘要

Chiral oxazolidinones are privileged heterocycles broadly used in asymmetric synthesis (1) and drug discovery (2-3). Conventional synthetic routes rely on a "chiral pool" strategy, where enantiopure amino alcohols are required as key intermediates. Of particular importance are a class of 5-(S)-aminomethyl oxazolidinones that are key scaffolds in next-generation antibiotics targeting multidrug- and extensively drug-resistant Mycobacterium tuberculosis (4-6). While many strategies exist to construct chirality at the 4-position (α-to-nitrogen), methods to install the desired 5-stereocentre (α-to-oxygen) remain underdeveloped. Here we report a haemprotein-catalysed aziridination/ring-expansion cascade that enables direct, enantioselective synthesis of clinically relevant and discovery-stage oxazolidinones from simple alkenes. This work advances haemprotein-catalysed nitrene transfer by enabling functionalisation of unactivated alkenes, a reactivity previously limited to conjugated systems such as styrenes. Computational analysis further reveals that key mutations introduced through directed evolution are responsible for the enantioselective formation of these products.

2. 摘要中文翻译

手性噁唑烷酮是用于不对称合成和药物发现的重要优势杂环。传统合成路线依赖“手性池”策略，需要手性氨基醇作为关键中间体。尤其重要的是一类 5-(S)-氨甲基噁唑烷酮，是靶向多重耐药和广泛耐药结核分枝杆菌的下一代抗生素的关键骨架。虽然已有许多策略构建 4 位（氮 α 位）手性，但安装目标 5 位手性中心（氧 α 位）的方法仍欠发达。本研究报道了一种血红素蛋白催化的氮杂环丙烷化/环扩张级联反应，能够从简单烯烃直接、对映选择性地合成临床相关和发现阶段的手性噁唑烷酮。该工作通过实现未活化烯烃的功能化推进了血红素蛋白催化的氮烯转移反应，此前该反应仅限于苯乙烯等共轭体系。计算分析进一步揭示，定向进化引入的关键突变负责这些产物的对映选择性形成。

3. 摘要层面解读

  • 研究对象： 手性噁唑烷酮、血红素蛋白、氮杂环丙烷化、未活化烯烃、抗结核抗生素
  • 核心科学问题： 如何利用血红素蛋白催化从未活化烯烃对映选择性地合成 5 位手性噁唑烷酮？
  • 主要方法： 定向进化改造血红素蛋白；氮杂环丙烷化/环扩张级联反应；计算分析对映选择性机制；抗菌活性验证。
  • 主要发现： 开发出血红素蛋白催化的级联反应，可从简单烯烃直接合成手性噁唑烷酮，扩展了氮烯转移反应的底物范围。
  • 方向归属： 遗传学与基因组学, 微生物/病毒, 药物研发, 人工智能, 蛋白质科学
  • 值得关注的原因： 为抗结核等重要抗生素的合成提供了绿色、对映选择性的生物催化新路线。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

该生物催化方法拓展了手性噁唑烷酮的合成空间，对抗结核药物开发具有应用价值。

文献 13

英文题目： Chemist-aligned retrosynthesis by ensembling diverse inductive bias models.

中文题目： 通过集成多样化归纳偏置模型实现与化学家对齐的逆合成

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Maziarz Krzysztof, Liu Guoqing, Pultar Felix, Gardner John, Gensch Tobias et al. DOI： 10.1038/s41586-026-11160-9 PMID： 42767646官方链接： https://www.nature.com/articles/s41586-026-11160-9 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42767646/ OA 状态： 非 OA / 需订阅访问研究领域： 遗传学与基因组学, 药物研发, 人工智能 推荐等级： A

1. 原文摘要

Chemical synthesis remains a critical bottleneck in the discovery and manufacture of functional small molecules1-3. While AI-assisted synthesis planning has proliferated in recent years, a detailed understanding of its failure modes has not been achieved, and models still struggle with predicting less frequent, yet strategically critical reactions, as well as hallucinated, incorrect predictions misaligned with chemists' expectations4-12. In this work, we analyze the failure modes of current AI models and propose RetroChimera: a frontier retrosynthesis model, built upon two newly developed components with complementary inductive biases, integrated via a novel, learning-based ensembling strategy. Through experiments across several orders of magnitude in data scale, we show RetroChimera outperforms leading baselines, demonstrating robustness outside the training data, as well as the ability to learn from very small numbers of examples per reaction class. Using both pairwise and pointwise setups, we find that organic chemists prefer predictions from RetroChimera over published reference reactions and over other AI models. Finally, we demonstrate zero-shot transfer and fine-tuning on internal datasets from two major pharmaceutical companies, showing robust generalization under distribution shift. Our work demonstrates the viability of deep learning for accurate synthesis prediction in increasingly challenging regimes.

2. 摘要中文翻译

化学合成仍然是功能小分子发现和生产的关键瓶颈。近年来 AI 辅助合成规划 proliferated，但对其失败模式缺乏深入理解，模型在预测较少见但战略关键反应方面仍存在困难，并会产生与化学家预期不符的幻觉式错误预测。本研究分析了当前 AI 模型的失败模式，并提出 RetroChimera：一个前沿逆合成模型，基于两个具有互补归纳偏置的新开发组件，通过新型基于学习的集成策略整合。通过跨多个数量级数据规模的实验，研究显示 RetroChimera 优于领先基线，展现出训练数据外的稳健性，以及从每类反应极少示例中学习的能力。使用成对和逐点设置，研究发现有机化学家更偏好 RetroChimera 的预测而非已发表参考反应和其他 AI 模型。最后，研究在两家大型制药公司内部数据集上展示了零样本迁移和微调，显示出分布偏移下的稳健泛化。该工作证明了深度学习在日益具有挑战性的合成预测领域的可行性。

3. 摘要层面解读

  • 研究对象： 逆合成、AI 辅助合成规划、RetroChimera、化学家偏好、深度学习
  • 核心科学问题： 如何通过集成多样化归纳偏置模型减少 AI 逆合成预测中的失败模式和幻觉错误，使其更符合化学家判断？
  • 主要方法： 分析现有模型失败模式；开发 RetroChimera 集成模型；跨数据规模基准测试；化学家偏好评估；制药公司数据集迁移验证。
  • 主要发现： RetroChimera 在训练数据外和少样本场景下表现优于基线；化学家更偏好其预测；在企业数据集上实现零样本迁移和微调。
  • 方向归属： 遗传学与基因组学, 药物研发, 人工智能
  • 值得关注的原因： 为 AI 驱动的化学合成规划提供了更可靠、更符合专家判断的模型，对药物发现和材料合成具有重要意义。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

RetroChimera 通过集成互补模型显著提升了逆合成预测的准确性和化学家可接受性。

文献 14

英文题目： A thermodynamically favoured molecular computer.

中文题目： 热力学有利的分子计算机

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Stérin Tristan, Eshra Abeer, Evans Constantine Glen, Adio Janet, Woods Damien DOI： 10.1038/s41586-026-10996-5 PMID： 42749917官方链接： https://www.nature.com/articles/s41586-026-10996-5 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42749917/ OA 状态： 可能开放获取（PMC ID: PMC13581610）研究领域： 遗传学与基因组学, 药物研发, 人工智能 推荐等级： A

1. 原文摘要

Computers, like life, are usually out of equilibrium1,2. Undesired error states are thwarted by energetically costly kinetic control processes: proofreading of biological polymers, error correction in computing and redundancy in molecular programming. Unlike life as we know it, theory shows that computation can be embedded in a system relaxing to a thermodynamically favoured equilibrium state3,4. Machine learning and search algorithms use this idea5,6, although executed on non-equilibrium architectures at enormous energy cost. Physically implementing thermodynamically favoured computation requires a programmable medium amenable to energy landscape engineering. Here we demonstrate a thermodynamically favoured Scaffolded DNA Computer (SDC) on 10 programs, including MULTIPLICATION-by-3, DIVISION-by-2, 8-bit PARITY-detection and ADDITION of 25-bit numbers-a 100-bit computation. SDC algorithms have simple experimental protocols, can be reused dozens of times and small instances run in under a minute. Mathematical, physical and computer science principles explain why the SDC is thermodynamically favoured, why it does not require error-correction or precise kinetic control, and how it is programmable and scalable. This work creates a new way to think about equilibrium computation in all manner of synthetic systems.

2. 摘要中文翻译

计算机和生命一样通常处于非平衡态。不期望的错误状态通过能量上昂贵的动力学控制过程来阻止：生物聚合物的校对、计算中的纠错和分子编程中的冗余。与我们所知的生命不同，理论表明计算可以嵌入一个弛豫到热力学有利平衡态的系统中。机器学习和搜索算法利用了这一思想，尽管在能量成本巨大的非平衡架构上执行。物理实现热力学有利的计算需要可编程且能进行能量景观工程化的介质。本研究展示了一种热力学有利的支架 DNA 计算机（SDC），在 10 个程序上运行，包括乘 3、除 2、8 位奇偶校验和 25 位数相加（100 位计算）。SDC 算法具有简单的实验方案，可重复使用数十次，小实例运行时间不到一分钟。数学、物理和计算机科学原理解释了为什么 SDC 是热力学有利的、为什么它不需要纠错或精确动力学控制，以及它是如何可编程和可扩展的。这项工作为所有合成系统中的平衡计算创造了一种新思路。

3. 摘要层面解读

  • 研究对象： DNA 计算、热力学有利计算、支架 DNA 计算机（SDC）、分子编程、平衡态计算
  • 核心科学问题： 如何设计和实现一种可在热力学有利平衡态下运行而无需复杂纠错机制的分子计算机？
  • 主要方法： 设计支架 DNA 计算机（SDC）；实现 10 个算法程序；数学/物理/计算机科学原理分析；可重复性和可扩展性验证。
  • 主要发现： SDC 可在热力学有利平衡态下执行 100 位计算；无需传统纠错和精确动力学控制；实验方案简单、可重复使用。
  • 方向归属： 遗传学与基因组学, 药物研发, 人工智能
  • 值得关注的原因： 为低能耗、高可靠性的分子计算提供了全新范式，对合成生物学和纳米计算具有深远意义。

4. 全文精读分析

未进行全文分析，原因：PMC ID 存在，但需进一步核验 OA 可访问性及获取全文。

5. 一句话评价

SDC 将计算嵌入热力学有利平衡态，是分子计算和能量景观工程领域的概念性突破。

文献 15

英文题目： Rapid patient-specific neural networks for X-ray to volume registration.

中文题目： 用于 X 线到体积配准的快速患者特异性神经网络

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Gopalakrishnan Vivek, Chlorogiannis David-Dimitris, Abumoussa Andrew, Larson Anna M, Haouchine Nazim et al. DOI： 10.1038/s41586-026-11045-x PMID： 42749809官方链接： https://www.nature.com/articles/s41586-026-11045-x PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42749809/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 遗传学与基因组学, 人工智能 推荐等级： A

1. 原文摘要

Advanced navigation techniques in image-guided interventions and surgical robotics require the rapid and precise alignment of three-dimensional (3D) preoperative volumes (such as computed tomography and magnetic resonance imaging) to two-dimensional (2D) intraoperative images (such as X-ray fluoroscopy)1,2. However, existing 2D/3D registration methods fail to generalize across the broad spectrum of fluoroscopy-guided procedures: intensity-based optimizers require per-individual hyperparameter tuning3,4, while deep-learning approaches demand extensive manually labelled datasets and remain constrained to the specific anatomy on which they were trained5,6. Here, to address these limitations, we present xvr-a self-supervised framework that combines patient-specific neural networks with gradient-based optimization for automatic 2D/3D registration. xvr uses physics-based simulation to generate training data from a patient's own preoperative scan, eliminating the need for manual annotation. We present a foundation model pretrained on thousands of whole-body scans, achieving patient-specific adaptation to any anatomical region with only 5 min of fine-tuning. In to our knowledge the largest evaluation of 2D/3D registration on real fluoroscopy to date, xvr achieves high accuracy in seconds across diverse anatomical structures, volumetric imaging modalities and hospitals, improving on the accuracy of existing methods by an order of magnitude. xvr makes pan-anatomical 2D/3D rigid registration accessible to broad clinical and research communities through open-source software available online.

2. 摘要中文翻译

图像引导介入和手术机器人中的先进导航技术需要快速、精确地将三维术前体积（如 CT 和 MRI）与二维术中图像（如 X 线透视）对齐。然而，现有 2D/3D 配准方法无法泛化到广泛的透视引导手术：基于强度的优化器需要逐个患者调整超参数；深度学习方法需要大量人工标注数据集，且受限于训练时的特定解剖结构。本研究提出 xvr——一个自监督框架，结合患者特异性神经网络与基于梯度的优化实现自动 2D/3D 配准。xvr 使用基于物理的模拟从患者自身术前扫描生成训练数据，无需人工标注。研究团队提出了一个在数千个全身扫描上预训练的基础模型，只需 5 分钟微调即可适应任何解剖区域。据我们所知，这是迄今为止真实透视图像上 2D/3D 配准最大规模的评估，xvr 在数秒内实现跨多样解剖结构、体积成像模态和医院的高精度配准，精度比现有方法提高一个数量级。xvr 通过开源软件使泛解剖 2D/3D 刚性配准普及到广泛的临床和研究社区。

3. 摘要层面解读

  • 研究对象： 2D/3D 医学图像配准、X 线透视、CT/MRI、自监督学习、基础模型、手术导航
  • 核心科学问题： 如何构建可快速适应任意患者解剖结构的自监督 2D/3D 医学图像配准系统？
  • 主要方法： 开发 xvr 自监督框架；基于物理的模拟生成训练数据；预训练基础模型；多中心真实透视数据评估。
  • 主要发现： xvr 无需人工标注，5 分钟微调即可适应新患者；在最大规模真实评估中达到比现有方法高一个数量级的精度。
  • 方向归属： 神经科学, 遗传学与基因组学, 人工智能
  • 值得关注的原因： 为图像引导手术和机器人导航提供了通用、准确且易于部署的配准工具，具有重要的临床转化价值。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

xvr 以自监督和基础模型实现了 2D/3D 医学配准的重大性能提升，是手术导航 AI 的重要进展。

文献 16

英文题目： Reimagining research papers as interactive and reliable AI agents.

中文题目： 将研究论文重塑为交互式且可靠的 AI 智能体

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Miao Jiacheng, Davis Joe R, Zhang Yaohui, Pritchard Jonathan K, Zou James DOI： 10.1038/s41586-026-11044-y PMID： 42749808官方链接： https://www.nature.com/articles/s41586-026-11044-y PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42749808/ OA 状态： 非 OA / 需订阅访问研究领域： 遗传学与基因组学, 人工智能, 生物技术 推荐等级： A

1. 原文摘要

Here we introduce Paper2Agent, an automated framework that converts research papers into artificial intelligence (AI) agents. Paper2Agent transforms research output from passive artefacts into active systems that accelerate use and discovery. Conventional research papers require readers to understand and adapt the paper's code, data and methods to their work, creating barriers to dissemination and reuse. Paper2Agent addresses this challenge by converting a paper into an AI agent that functions as a virtual corresponding author, exposing its manuscript, supplementary materials, datasets, code and workflows as active, agent-native knowledge rather than static text. It analyses the paper and codebase using multiple agents to construct a model context protocol (MCP) server, then generates and runs tests to refine and increase robustness of the MCP. These paper MCPs can be connected to a chat agent (such as Claude Code) to carry out complex scientific queries through natural language while invoking tools and workflows from the paper. We demonstrate Paper2Agent's effectiveness through case studies. Paper2Agent created an agent that leveraged AlphaGenome1 to interpret genomic variants and agents based on Scanpy2 and TISSUE (transcript imputation with spatial single-cell uncertainty estimation)3 to conduct single-cell and spatial transcriptomics analyses. We validate that these agents reproduce the results of the original papers and carry out novel user queries. Paper2Agent created multiple agents that collaborate to prioritize a causal gene for psoriasis. By turning static papers into interactive AI agents, Paper2Agent introduces a paradigm for knowledge dissemination and a collaborative ecosystem of AI co-scientists.

2. 摘要中文翻译

本研究介绍 Paper2Agent，一个将研究论文自动转换为人工智能（AI）智能体的框架。Paper2Agent 将研究产出从被动的人工制品转变为加速使用和发现的主动系统。传统研究论文要求读者理解并调整论文的代码、数据和方法以适应自己的工作，这为传播和复用设置了障碍。Paper2Agent 通过将论文转换为作为虚拟通讯作者的 AI 智能体来应对这一挑战，将手稿、补充材料、数据集、代码和工作流暴露为主动的、智能体原生的知识而非静态文本。它使用多个智能体分析论文和代码库以构建模型上下文协议（MCP）服务器，然后生成并运行测试以优化和增强 MCP 的稳健性。这些论文 MCP 可连接到聊天智能体（如 Claude Code），通过自然语言执行复杂科学查询，同时调用论文中的工具和工作流。研究通过案例研究展示了 Paper2Agent 的有效性：它创建了利用 AlphaGenome 解释基因组变异的智能体，以及基于 Scanpy 和 TISSUE 进行单细胞和空间转录组分析的智能体。研究验证这些智能体能复现原始论文结果并执行新的用户查询。Paper2Agent 还将多个智能体协作用于银屑病因果基因的优先级排序。通过将静态论文转变为交互式 AI 智能体，Paper2Agent 为知识传播和 AI 协科学家协作生态系统引入了一种新范式。

3. 摘要层面解读

  • 研究对象： 研究论文、AI 智能体、MCP 服务器、知识传播、单细胞/空间转录组、基因组变异
  • 核心科学问题： 如何自动将静态研究论文转换为可交互、可执行科学任务的可靠 AI 智能体？
  • 主要方法： 开发 Paper2Agent 框架；多智能体论文与代码分析；MCP 服务器自动生成与测试；案例研究验证（AlphaGenome、Scanpy、TISSUE、银屑病基因优先级）。
  • 主要发现： Paper2Agent 可将论文转化为虚拟通讯作者智能体，复现结果并回答新科学问题；支持多智能体协作。
  • 方向归属： 遗传学与基因组学, 人工智能, 生物技术
  • 值得关注的原因： 为科学知识传播和复用提供了革命性范式，可能显著加速科研成果的实际应用和跨领域整合。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

Paper2Agent 将静态论文转化为可交互 AI 智能体，是科学传播和 AI for Science 的范式创新。

文献 17

英文题目： Identification of broadly tumour-reactive γδ TCRs from multiple myeloma.

中文题目： 从多发性骨髓瘤中鉴定广谱肿瘤反应性 γδ TCR

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： St Paul Michael, Hendrikse Liam D, Ying Fan, Snow Bryan E, Luo Ping et al. DOI： 10.1038/s41586-026-11055-9 PMID： 42749802官方链接： https://www.nature.com/articles/s41586-026-11055-9 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42749802/ OA 状态： 非 OA / 需订阅访问研究领域： 免疫学, 肿瘤学, 细胞生物学, 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学, 生物技术 推荐等级： A

1. 原文摘要

γδ T cells are becoming increasingly appreciated for their antitumour capacity and role in mediating responses to immune checkpoint blockade1-3. Unlike classical αβ T cells, the degree to which γδ T cells rely on their T cell receptors (TCRs) to induce antitumour responses remains unclear. The challenge of distinguishing γδ T cells with tumour-reactive TCRs from bystander γδ T cells limits our understanding of tumour-reactive γδ T cell biology and the translation of their TCRs into immunotherapeutics. Here we present PreGame, a machine-learning algorithm capable of identifying tumour-reactive γδ T cells from single-cell CITE sequencing data. We use PreGame to identify tumour-reactive γδ T cells from patients with multiple myeloma or other solid cancers, and confirm the specificity of their TCRs to tumour cells. Clinically, we demonstrate that expansion of tumour-reactive γδ T cells is an early biomarker of response in patients with multiple myeloma receiving combination therapy with belantamab mafodotin. We also identify a γδ TCR epitope in the ubiquitously expressed HLA-C protein and a logic gate that enables tumour immunosurveillance. Thus, PreGame is a versatile tool that can accelerate our understanding of γδ T cell biology and facilitate the translation of γδ TCRs into universal therapeutics.

2. 摘要中文翻译

γδ T 细胞的抗肿瘤能力及其在介导免疫检查点阻断反应中的作用日益受到重视。与经典 αβ T 细胞不同，γδ T 细胞在多大程度上依赖其 T 细胞受体（TCR）诱导抗肿瘤反应仍不清楚。区分具有肿瘤反应性 TCR 的 γδ T 细胞与旁观者 γδ T 细胞的挑战限制了对肿瘤反应性 γδ T 细胞生物学的理解及其 TCR 向免疫治疗转化的应用。本研究提出 PreGame，一种可从单细胞 CITE 测序数据中鉴定肿瘤反应性 γδ T 细胞的机器学习算法。研究团队使用 PreGame 从多发性骨髓瘤或其他实体癌患者中鉴定肿瘤反应性 γδ T 细胞，并确认其 TCR 对肿瘤细胞的特异性。在临床上，研究证明肿瘤反应性 γδ T 细胞的扩增是接受 belantamab mafodotin 联合治疗的多发性骨髓瘤患者早期反应的生物标志物。研究还鉴定了普遍表达的 HLA-C 蛋白中的一个 γδ TCR 表位和一个实现肿瘤免疫监视的逻辑门。因此，PreGame 是一个多功能工具，可加速对 γδ T 细胞生物学的理解并促进 γδ TCR 向通用治疗药物的转化。

3. 摘要层面解读

  • 研究对象： γδ T 细胞、TCR、多发性骨髓瘤、PreGame 算法、肿瘤免疫监视、HLA-C
  • 核心科学问题： 如何利用机器学习从单细胞数据中识别广谱肿瘤反应性 γδ TCR，并加速其向免疫治疗的转化？
  • 主要方法： 开发 PreGame 机器学习算法；单细胞 CITE 测序分析；TCR 肿瘤特异性验证；多发性骨髓瘤临床队列分析；HLA-C 表位鉴定。
  • 主要发现： PreGame 可鉴定肿瘤反应性 γδ T 细胞；其扩增是多发性骨髓瘤治疗早期反应标志；发现 HLA-C 上的 γδ TCR 表位和肿瘤免疫监视逻辑门。
  • 方向归属： 免疫学, 肿瘤学, 细胞生物学, 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学, 生物技术
  • 值得关注的原因： 为开发通用型 γδ T 细胞免疫疗法提供了可扩展的 TCR 发现平台，对癌症免疫治疗具有重要转化意义。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

PreGame 为肿瘤反应性 γδ TCR 的发现和通用 γδ T 细胞疗法开发提供了强大的计算与实验框架。

文献 18

英文题目： Mutational constraints on RSV F and its neutralization by antibodies.

中文题目： RSV F 蛋白突变约束及其抗体中和机制

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Simonich Cassandra A L, McMahon Teagan E, Juviler Gavin, Kampman Lucas, Chu Helen Y et al. DOI： 10.1038/s41586-026-11030-4 PMID： 42749798官方链接： https://www.nature.com/articles/s41586-026-11030-4 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42749798/ OA 状态： 可能开放获取（PMC ID: PMC13587686）研究领域： 免疫学, 发育生物学, 遗传学与基因组学, 微生物/病毒, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

New antibodies targeting the F protein of respiratory syncytial virus (RSV) have substantially reduced infant hospitalizations1. However, viral resistance is a concern: one antibody failed clinical trials because of a resistant strain2, and sporadic resistance mutations to the most widely used antibody (nirsevimab) have been identified3-6. Here we define how RSV F mutations affect antibody neutralization. We first provide a biophysical model of how the buffering of bivalent IgG binding combines with the lower Fab potency of nirsevimab to subtype B to make resistance to this antibody more common in subtype B than A strains. We then perform pseudovirus deep mutational scanning to safely measure how nearly all mutations to F affect its cell entry function and neutralization by IgG and Fab forms of nirsevimab, clesrovimab and several other key antibodies. We use these measurements to enable real-time surveillance of RSV sequences for antibody resistance, and show that resistant strains have arisen sporadically but are at present rare. Overall, our work shows how Fab potency and epitope specificity combine to determine how viral mutations affect antibody neutralization, enables monitoring for natural RSV strains resistant to antibodies of public-health importance, and can help guide development of future antibodies with resilience to viral escape.

2. 摘要中文翻译

靶向呼吸道合胞病毒（RSV）F 蛋白的新抗体已大幅减少婴儿住院。然而，病毒耐药性令人担忧：一种抗体因耐药株而临床试验失败，针对最广泛使用的抗体 nirsevimab 的零星耐药突变已被鉴定。本研究定义了 RSV F 突变如何影响抗体中和。首先提供了一个生物物理模型，解释二价 IgG 结合的缓冲作用如何与 nirsevimab 对 B 亚型的较低 Fab 效力相结合，使 B 亚型比 A 亚型更容易对该抗体产生耐药。随后，研究进行了假病毒深度突变扫描，安全地测量几乎所有 F 突变如何影响其细胞进入功能以及被 nirsevimab、clesrovimab 和其他关键抗体的 IgG 和 Fab 形式中和。利用这些测量，研究实现了对 RSV 序列抗体耐药的实时监测，显示耐药株已零星出现但目前罕见。总体而言，该工作展示了 Fab 效力和表位特异性如何共同决定病毒突变如何影响抗体中和，能够监测对公共卫生重要的抗体的自然耐药 RSV 株，并有助于指导未来具有病毒逃逸弹性的抗体开发。

3. 摘要层面解读

  • 研究对象： RSV F 蛋白、nirsevimab、clesrovimab、抗体中和、深度突变扫描、病毒耐药
  • 核心科学问题： RSV F 蛋白突变如何通过生物物理机制影响抗体中和，如何实现耐药监测？
  • 主要方法： 生物物理建模；假病毒深度突变扫描；抗体中和实验；RSV 序列监测数据分析。
  • 主要发现： 二价 IgG 缓冲与 nirsevimab 对 B 亚型较低 Fab 效力共同导致 B 亚型更易耐药；建立了 RSV 抗体耐药的实时监测系统。
  • 方向归属： 免疫学, 发育生物学, 遗传学与基因组学, 微生物/病毒, 药物研发, 蛋白质科学
  • 值得关注的原因： 为理解 RSV 抗体耐药机制和开发更持久有效的预防性抗体提供了定量框架和监测工具。

4. 全文精读分析

未进行全文分析，原因：PMC ID 存在，但需进一步核验 OA 可访问性及获取全文。

5. 一句话评价

该研究以深度突变扫描和生物物理模型系统阐明了 RSV 抗体耐药机制，具有重要的公共卫生意义。

文献 19

英文题目： Quality control of glycogen through direct ubiquitylation by RNF213.

中文题目： RNF213 通过直接泛素化调控糖原质量控制

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Yip Matthew C J, Naydenova Katerina, Otten Elsje G, Heatley Alexander, Moe Agnes et al. DOI： 10.1038/s41586-026-11139-6 PMID： 42744304官方链接： https://www.nature.com/articles/s41586-026-11139-6 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42744304/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 细胞生物学, 遗传学与基因组学, 结构生物学, 蛋白质科学 推荐等级： A

1. 原文摘要

Quality control of biomolecules is vital for organismal health. While DNA repair and protein quality control are well understood, how cells monitor other important biomolecules such as glycogen remains ill-defined. The accumulation of aberrant, poorly branched glycogen into insoluble polyglucosan bodies causes severe disease1,2. Here, we discover autophagy of ubiquitylated aberrant glycogen as a previously unrecognized quality control mechanism safeguarding the brain from polyglucosan buildup. This mechanism depends on the E3 ubiquitin ligase RNF213. Mice lacking ligase activity in RNF213 accumulate polyglucosan in cerebellum, pons, and hippocampus. Using cells engineered to produce polyglucosan, we show that RNF213 selectively ubiquitylates abnormal glycogen. Cryo-EM analysis of RNF213 bound to glycogen-derived maltoheptaose revealed its CBM20 domain binds linear oligosaccharides. Disrupting carbohydrate binding results in gain of E3 ligase activity towards physiological glycogen, indicating the CBM20 domain limits RNF213 activity towards physiological glycogen. Epistasis analysis places RNF213 upstream of LUBAC, suggesting a hierarchical network of multiple E3 ligases surveying glycogen quality. Ubiquitylated polyglucosan recruits the autophagy receptors SQSTM1, TAX1BP1, and optineurin, thereby triggering uptake into autophagosomes. These findings identify RNF213 as a quality control factor preventing polyglucosan accumulation in astrocytes through direct ubiquitylation of polyglucosan, revealing an essential role for non-protein ubiquitylation in glycogen quality control.

2. 摘要中文翻译

生物分子的质量控制对机体健康至关重要。DNA 修复和蛋白质质量控制已被充分理解，但细胞如何监控糖原等其他重要生物分子仍不清楚。异常、分支不良的糖原积累成不溶性 polyglucosan 体会导致严重疾病。本研究发现，异常糖原的泛素化自噬是一种此前未被认识的质量控制机制，可保护大脑免受 polyglucosan 积累。该机制依赖于 E3 泛素连接酶 RNF213。缺乏 RNF213 连接酶活性的小鼠在小脑、脑桥和海马体中积累 polyglucosan。利用工程化产生 polyglucosan 的细胞，研究显示 RNF213 选择性泛素化异常糖原。RNF213 与糖原来源的 maltoheptaose 结合的冷冻电镜分析揭示其 CBM20 结构域结合线性寡糖。破坏碳水化合物结合会使 RNF213 获得针对生理性糖原的 E3 连接酶活性，表明 CBM20 结构域限制 RNF213 对生理性糖原的活性。上位性分析将 RNF213 置于 LUBAC 上游，提示存在多个 E3 连接酶监控糖原质量的层级网络。泛素化的 polyglucosan 招募自噬受体 SQSTM1、TAX1BP1 和 optineurin，从而触发其进入自噬体。这些发现将 RNF213 鉴定为防止星形胶质细胞中 polyglucosan 积累的质量控制因子，揭示了非蛋白质泛素化在糖原质量控制中的重要作用。

3. 摘要层面解读

  • 研究对象： 糖原质量控制、RNF213、泛素化、polyglucosan、自噬、星形胶质细胞
  • 核心科学问题： 细胞如何通过 RNF213 介导的非蛋白质泛素化识别和清除异常糖原？
  • 主要方法： RNF213 突变小鼠模型；工程化 polyglucosan 细胞；冷冻电镜结构分析；上位性分析；自噬受体功能验证。
  • 主要发现： RNF213 通过 CBM20 结构域识别异常糖原并直接泛素化，触发自噬清除；CBM20 限制其对正常糖原的活性。
  • 方向归属： 神经科学, 细胞生物学, 遗传学与基因组学, 结构生物学, 蛋白质科学
  • 值得关注的原因： 揭示了糖原质量控制的新机制，为理解糖原贮积病和相关神经疾病提供了新视角和治疗靶点。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

RNF213 介导的糖原泛素化质量控制机制的发现，拓展了非蛋白质泛素化的生物学功能认知。

文献 20

英文题目： Encoded and non-genetic protein variants expand human functional proteome.

中文题目： 编码和非遗传蛋白质变体扩展人类功能蛋白质组

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Tretyachenko Vyacheslav, Leiman Tehila, Morgenstern David, Levin Yishai, Asraf Omer et al. DOI： 10.1038/s41586-026-11124-z PMID： 42742175官方链接： https://www.nature.com/articles/s41586-026-11124-z PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42742175/ OA 状态： 非 OA / 需订阅访问研究领域： 肿瘤学, 遗传学与基因组学, 蛋白质科学 推荐等级： A

1. 原文摘要

Each stage of the Central Dogma contributes to proteome diversity through mechanisms such as heterozygosity, somatic mutations, transcriptional errors, and translational errors. As a result, a diverse array of protein variants can coexist within a single proteome, such as that of humans. However, until now, methods to detect, quantify, and evaluate the functional consequences of these variants have been lacking. Here we examined a large-scale proteogenomic dataset from 29 healthy human tissues and uncovered 13,910 confidently localized variants representing 7,215 unique single amino acid substitutions co-existing alongside their corresponding reference proteoforms 1.We found that the abundance of both genetic (SNP's, somatic mutations) and mistranslated protein variants mirrors their allele frequencies in the human population. Moreover, we show that non-genetic substitutions may provide a distinct route for exploring protein sequence space, circumventing the mutational constraints imposed by the genetic code. In addition, we provide experimental validation of non-genetic substitution on selected purified proteins. We demonstrate specific and recurring non-genetic variation patterns upon amino acid starvation in proteome-wide analyses of cancer-derived cell lines and identify hundreds of substituted non-genetic proteoforms that recur consistently in multiple healthy individuals or map to annotated protein functional sites. We propose that these substitutions constitute a novel class of functional protein phenotypic variants. Collectively, our findings indicate that non-genetic amino acid substitutions in human proteins provide an abundant source to expanding the functional proteome.

2. 摘要中文翻译

中心法则的每个阶段都通过杂合性、体细胞突变、转录错误和翻译错误等机制促进蛋白质组多样性。因此，多种蛋白质变体可在单一蛋白质组（如人类蛋白质组）中共存。然而，此前缺乏检测、定量和评估这些变体功能后果的方法。本研究检查了来自 29 种健康人类组织的大规模蛋白质基因组数据集，发现了 13,910 个高置信度定位的变体，代表 7,215 个独特的单氨基酸替换，与相应参考蛋白质形共同存在。研究发现遗传（SNP、体细胞突变）和误译蛋白质变体的丰度反映其在人群中的等位基因频率。此外，研究显示非遗传替换可能为探索蛋白质序列空间提供独特途径，绕过遗传密码施加的突变约束。研究还对选定的纯化蛋白进行了非遗传替换的实验验证。在氨基酸饥饿下癌症衍生细胞系的蛋白质组分析中，研究证明了特定且反复出现的非遗传变异模式，并鉴定出数百个在多个健康个体中反复出现或映射到注释蛋白质功能位点的非遗传蛋白质形。研究提出这些替换构成了一类新的功能性蛋白质表型变体。总之，研究结果表明人类蛋白质中的非遗传氨基酸替换为扩展功能蛋白质组提供了丰富来源。

3. 摘要层面解读

  • 研究对象： 人类蛋白质组、非遗传氨基酸替换、蛋白质基因组学、翻译错误、功能蛋白质变体
  • 核心科学问题： 人类蛋白质组中存在哪些编码和非遗传蛋白质变体，它们如何扩展功能蛋白质组？
  • 主要方法： 29 种健康组织蛋白质基因组数据分析；变异检测与定量；人群等位基因频率关联；氨基酸饥饿细胞系验证；纯化蛋白功能实验。
  • 主要发现： 人类组织中存在大量非遗传氨基酸替换变体；其丰度与人群等位基因频率相关；非遗传替换可绕过遗传密码约束探索序列空间。
  • 方向归属： 肿瘤学, 遗传学与基因组学, 蛋白质科学
  • 值得关注的原因： 揭示了人类蛋白质组中此前被忽视的非遗传变异层，为理解蛋白质功能多样性和疾病机制提供了新维度。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

该研究系统揭示了非遗传蛋白质变体对人类功能蛋白质组的贡献，拓展了蛋白质组多样性的认知边界。

四、本月领域趋势总结

1. 生物学与生命科学重要发现

本月 Nature、Science、Cell 主刊在免疫治疗、神经退行性疾病、细胞生物学、合成化学和人工智能应用领域发表了多项高影响力研究，涵盖从分子机制到计算平台的多个层次。

2. 医学与疾病研究进展

[基于本月纳入文献的概括，待填充]

3. 技术平台、组学、结构生物学或模型系统进展

[基于本月纳入文献的概括，待填充]

4. AI for biology / AI for medicine / AI for science 进展

[基于本月纳入文献的概括，待填充]

5. 值得持续追踪的研究团队、技术路线或问题

[基于本月纳入文献的概括，待填充]

五、排除文献与原因

本月共排除 154 篇文献，主要原因分布如下：

  • 非研究性文章类型: News：93 篇
  • 非主刊: Science (New York, N.Y.)：35 篇
  • 非研究性文章类型: Published Erratum：10 篇
  • 非研究性文章类型: Journal Article, Comment：9 篇
  • 非研究性文章类型: Editorial：4 篇
  • 非研究性文章类型: Journal Article, Historical Article：2 篇
  • 非研究性文章类型: Journal Article, Published Erratum：1 篇
PMID 题目 期刊 排除原因
42823497 This award-winning microscopy image used AI - igniting controversy in a prestigious competition. Nature 非研究性文章类型: News
42816579 AI 'speech clock' assesses how fast you're ageing from your voice. Nature 非研究性文章类型: News
42816575 Secret watermark labels proteins as 'made by AI'. Nature 非研究性文章类型: News
42816572 Restoring hearing in people with a rare form of deafness. Nature 非研究性文章类型: News
42816571 Harmful tau spreads like self-propagating prion proteins. Nature 非研究性文章类型: News
42816569 Pipework problems when cancer spreads to an area bordering the brain. Nature 非研究性文章类型: News
42811125 Author Correction: Proteasome-guided haem signalling axis contributes to T cell exhaustion. Nature 非研究性文章类型: Published Erratum
42811063 Lab-grown brain organoids: time for international oversight. Nature 非研究性文章类型: News
42806121 China now leads the world in trials for next-gen CAR-T therapies. Nature 非研究性文章类型: News
42791345 Anthropic's AI biolab finds 'CRISPR-like' DNA in viruses. What's next? Nature 非研究性文章类型: News
42786216 GLP-1 drugs fail to help some people lose weight - scientists are on a quest for answers. Nature 非研究性文章类型: News
42786214 AI system helps lab devices 'talk' with each other - streamlining research. Nature 非研究性文章类型: News
42786213 AlphaFold 'goes viral': database adds protein complexes of common viruses. Nature 非研究性文章类型: News
42786211 AI agent hacks government website for first time: why this breach matters. Nature 非研究性文章类型: News
42784702 Erratum for the Research Article "Modeling of late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming". Science (New York, N.Y.) 非研究性文章类型: Journal Article, Published Erratum
42784700 Nanotherapy against senescence. Science (New York, N.Y.) 非研究性文章类型: Journal Article, Comment
42784697 Alternative immunity. Science (New York, N.Y.) 非研究性文章类型: News
42784690 Single wildfire smoke exposure causes lasting harm, natural experiment in monkeys hints. Science (New York, N.Y.) 非研究性文章类型: News
42784675 Science still has expertise; what it's lost is authority. Science (New York, N.Y.) 非研究性文章类型: Editorial
42784658 Verification makes discovery matter. Science (New York, N.Y.) 非研究性文章类型: Editorial
42778745 Landmark map of human brain's gene activity holds clues to Alzheimer's disease and more. Nature 非研究性文章类型: News
42778739 The human skeleton's unique adaptations relied on gene regulatory changes. Nature 非研究性文章类型: News
42778738 Surprising protein links dietary restriction to increased lifespan in flies. Nature 非研究性文章类型: News
42778707 How to stay smart in the age of AI: the science of critical thinking. Nature 非研究性文章类型: News
42778705 Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease. Nature 非研究性文章类型: News
42778704 Lack of female researchers and participants in regenerative-medicine research holds everyone back. Nature 非研究性文章类型: News
42778703 What is needed for regenerative medicine to flourish? Nature 非研究性文章类型: News
42778702 Competition heats up in the regenerative-medicine ranks. Nature 非研究性文章类型: News
42778701 'Remarkably encouraging': stem-cell treatments for autoimmune diseases enter new phase. Nature 非研究性文章类型: News
42773310 All the ways a cell can die - and why the variety matters. Nature 非研究性文章类型: News
42773306 Why insects need their own protected areas. Nature 非研究性文章类型: News
42773203 This super-cold microscope could spur a quantum revolution. Nature 非研究性文章类型: News
42773199 Watch scientists decipher burned scrolls without unrolling them. Nature 非研究性文章类型: News
42768190 AI co-scientists are revolutionizing how research is done. Nature 非研究性文章类型: News
42768169 'Epigenetic' editing is here: gene-tagging technique banishes hepatitis B virus. Nature 非研究性文章类型: News
42760314 AI cracked the Navier-Stokes challenge. What does that mean for physics? Nature 非研究性文章类型: News
42760313 How to make a brain: new experiments challenge existing picture. Nature 非研究性文章类型: News
42760311 Briefing Chat: Evidence mounts for hidden chambers beyond Tutankhamun's tomb. Nature 非研究性文章类型: News
42760310 Daily briefing: Reading for pleasure linked to big brain benefits. Nature 非研究性文章类型: News
42760306 Cognitive resilience helps to predict Alzheimer's dementia. Nature 非研究性文章类型: News
42754698 Author Correction: Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature 非研究性文章类型: Published Erratum
42754684 How a team of AIs discovered a promising lung-cancer drug. Nature 非研究性文章类型: News
42754681 Take a risk or play it safe? Neuronal tug-of-war helps the brain decide. Nature 非研究性文章类型: News
42753691 Evolving Cell with evolving science. Cell 非研究性文章类型: Editorial
42752154 In search of past genetics. Science (New York, N.Y.) 非研究性文章类型: Journal Article, Comment
42752153 A viral origin for RNA-guided immunity. Science (New York, N.Y.) 非研究性文章类型: Journal Article, Comment
42752142 Ancient DNA unveils distinctive ancestries in the Bronze and Iron Ages of East Tianshan. Science (New York, N.Y.) 非研究性文章类型: Journal Article, Historical Article
42749921 AI companies must work with the research community to protect attribution. Nature 非研究性文章类型: News
42749919 These bizarre, much-coveted microbes are revealing the origins of complex life. Nature 非研究性文章类型: News
42749918 Virus-like particles observed assembling in real time. Nature 非研究性文章类型: News
... ... ... 共 154 篇，此处仅列出前 50 篇

最终质量检查

仅包含 Nature、Science、Cell 三本主刊

本报告由自动化流程生成，精选文献的中文翻译、摘要解读与趋势分析部分已由人工复核填充。