生物文献研读笔记 生物医学文献追踪与解读
月报 CNS 主刊

Nature_Science_Cell主刊文献月报_2026-10

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Nature、Science、Cell 生物医学与 AI 文献月报

统计月份： 2026-10检索日期： 2026-11-06 覆盖时间： 2026/10/01 至 2026/10/31检索期刊： Nature、Science、Cell（仅限主刊）检索来源： PubMed E-utilities（ESearch + EFetch）、期刊官方 DOI 页面、PubMed Central 纳入标准： Nature/Science/Cell 主刊发表的研究论文；主题涉及生物学、医学、生命科学、生物技术、神经科学、免疫学、肿瘤学、发育生物学、细胞生物学、遗传学与基因组学、蛋白质科学/结构生物学、微生物/病毒/感染、药物研发/诊断/治疗，或人工智能与生命科学/医学/药物研发的交叉研究；排除新闻、社论、评论、勘误等非研究性文章。 排除标准： 非主刊（子刊）文章；与生物医学/AI 无关的文章；新闻、社论、评论、书评、人物访谈、政策评论；信息无法核验的文章；DOI/摘要/官方链接缺失的文章。

本月结果概览

  • PubMed 检索命中 PMIDs：384 条
  • 成功获取元数据：384 篇
  • 研究性文章：253 篇
  • Nature/Science/Cell 主刊研究性文章：200 篇
  • 排除非研究性文章：131 篇
  • 排除非主刊文章：45 篇
  • 本报告详细解读精选文献：20 篇

一、本月高价值文献总表

序号 题目 期刊 发表日期 研究领域 文章类型 PMID DOI OA 状态 推荐等级
1 Connectome simulations identify a central pattern generator for fly walking. Nature 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42951971 10.1038/s41586-026-11195-y 非 OA / 需订阅访问 A
2 Genetic variants shape single-cell chromatin accessibility and disease risk. Nature 未提供 神经科学、免疫学、遗传学与基因组学 Research Article 42951970 10.1038/s41586-026-11173-4 非 OA / 需订阅访问 A
3 Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers. Nature 未提供 肿瘤学、发育生物学、细胞生物学 Research Article 42951963 10.1038/s41586-026-11178-z 非 OA / 需订阅访问 A
4 Programmable design of functional proteins from natural language. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42907516 10.1038/s41586-026-11205-z 非 OA / 需订阅访问 A
5 GRP75-dependent SIMPA mediates inter-organellar quality control. Nature 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42907503 10.1038/s41586-026-10733-y 非 OA / 需订阅访问 A
6 A microexon regulatory code reveals autism-linked genetic variation. Nature 未提供 神经科学、遗传学与基因组学、人工智能 Research Article 42875502 10.1038/s41586-026-11119-w 非 OA / 需订阅访问 A
7 Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism. Nature 未提供 免疫学、药物研发、蛋白质科学 Research Article 42875499 10.1038/s41586-026-11176-1 非 OA / 需订阅访问 A
8 Elp1 is required for myeloid differentiation and brain repopulation. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42875495 10.1038/s41586-026-11112-3 非 OA / 需订阅访问 A
9 Artificial intelligence-enabled clinical phenotyping of human brown fat. Nature 未提供 肿瘤学、遗传学与基因组学、微生物/病毒 Research Article 42875491 10.1038/s41586-026-11162-7 非 OA / 需订阅访问 A
10 De novo design of cysteine proteases. Nature 未提供 遗传学与基因组学、药物研发、人工智能 Research Article 42875488 10.1038/s41586-026-11143-w 非 OA / 需订阅访问 A
11 Computational design of metalloproteases. Nature 未提供 免疫学、药物研发、人工智能 Research Article 42875487 10.1038/s41586-026-11167-2 非 OA / 需订阅访问 A
12 Antiviral immunity via telomerase-like reverse transcription in bacteria. Nature 未提供 免疫学、遗传学与基因组学、结构生物学 Research Article 42863825 10.1038/s41586-026-11250-8 非 OA / 需订阅访问 A
13 A preinvasive regulatory T cell axis for lung cancer interception. Nature 未提供 免疫学、肿瘤学、发育生物学 Research Article 42844481 10.1038/s41586-026-11066-6 非 OA / 需订阅访问 A
14 Retrofitting language models to operate over bytes. Nature 未提供 神经科学、遗传学与基因组学、药物研发 Research Article 42844478 10.1038/s41586-026-11111-4 可能开放获取（PMC ID: PMC13686933） A
15 A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice. Nature 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42844473 10.1038/s41586-026-11142-x 非 OA / 需订阅访问 A
16 tRNA dosage regulates lineage dependency and resistance in prostate cancer. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42844465 10.1038/s41586-026-11153-8 非 OA / 需订阅访问 A
17 A split attractor design for rapidly writing a navigational goal. Nature 未提供 神经科学、药物研发、人工智能 Research Article 42844464 10.1038/s41586-026-11144-9 非 OA / 需订阅访问 A
18 Dynamic protrusions mediate crawling motility in Asgard archaea. Nature 未提供 细胞生物学、药物研发、人工智能 Research Article 42816618 10.1038/s41586-026-11063-9 可能开放获取（PMC ID: PMC13716822） A
19 Prion-like transmission of human tau strains in the mouse brain. Nature 未提供 神经科学、遗传学与基因组学、结构生物学 Research Article 42816607 10.1038/s41586-026-11061-x 可能开放获取（PMC ID: PMC13686949） A
20 Written in development and lost in ageing: the grammar of cellular identity. Nature 未提供 发育生物学、细胞生物学、遗传学与基因组学 Review 42816559 10.1038/s41586-026-10955-0 非 OA / 需订阅访问 A
21 MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42778593 10.1038/s41586-026-11048-8 可能开放获取（PMC ID: PMC13645644） A
22 Lsp2 links early-life diet to adult translation and lifespan in Drosophila. Nature 未提供 发育生物学、遗传学与基因组学、蛋白质科学 Research Article 42778590 10.1038/s41586-026-11031-3 可能开放获取（PMC ID: PMC13645648） A
23 Reimagining research papers as interactive and reliable AI agents. Nature 未提供 遗传学与基因组学、人工智能、生物技术 Research Article 42749808 10.1038/s41586-026-11044-y 可能开放获取（PMC ID: PMC13716825） A
24 Cohesin reshapes replication fork contacts to aid fork slowing and reversal. Nature 未提供 肿瘤学、细胞生物学、遗传学与基因组学 Research Article 42749806 10.1038/s41586-026-11034-0 可能开放获取（PMC ID: PMC13686946） A
25 Mutational constraints on RSV F and its neutralization by antibodies. Nature 未提供 免疫学、发育生物学、遗传学与基因组学 Research Article 42749798 10.1038/s41586-026-11030-4 可能开放获取（PMC ID: PMC13587686） A
26 Learning millisecond protein dynamics from what is missing in NMR spectra. Nature 未提供 结构生物学、药物研发、人工智能 Research Article 42742167 10.1038/s41586-026-10989-4 可能开放获取（PMC ID: PMC13733481） A
27 An operational perturbation proteomics-based virtual cell model. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42717098 10.1038/s41586-026-11001-9 非 OA / 需订阅访问 A
28 Imaging cellular activity across all organs reveals body-wide circuits. Nature 未提供 神经科学、免疫学、细胞生物学 Research Article 42717095 10.1038/s41586-026-10979-6 可能开放获取（PMC ID: PMC13716824） A
29 TRI-611, a selective, brain-penetrant molecular glue degrader of ALK. Nature 未提供 神经科学、肿瘤学、遗传学与基因组学 Research Article 42717093 10.1038/s41586-026-10998-3 非 OA / 需订阅访问 A
30 Proximity-guided graph learning reveals tumour-associated proximity antigens. Nature 未提供 肿瘤学、发育生物学、细胞生物学 Research Article 42717092 10.1038/s41586-026-11003-7 可能开放获取（PMC ID: PMC13716823） A
31 Functional chimeric mRNAs encode proteins in mammalian immunity. Nature 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42686912 10.1038/s41586-026-10982-x 可能开放获取（PMC ID: PMC13686932） A
32 Creating bottom-up RNA transfer vehicles from synthetic protein assemblies. Nature 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42686908 10.1038/s41586-026-10952-3 可能开放获取（PMC ID: PMC13668671） A
33 3D epigenome of glial cell types in developing human cortex. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42686907 10.1038/s41586-026-10987-6 可能开放获取（PMC ID: PMC13668669） A
34 Structure and operating principles of a monkeypox virus replisome. Nature 未提供 遗传学与基因组学、结构生物学、微生物/病毒 Research Article 42686903 10.1038/s41586-026-10937-2 可能开放获取（PMC ID: PMC13645618） A
35 Rewiring the ribosome to translate proteins encoded in its own RNA. Nature 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42686901 10.1038/s41586-026-10962-1 非 OA / 需订阅访问 A
36 A binding-to-release strategy for targeted anticancer drug delivery. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42649302 10.1038/s41586-026-10971-0 可能开放获取（PMC ID: PMC13668651） A
37 Insights into longevity and virus-driven adaptation from Myotis bat genomes. Nature 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42649300 10.1038/s41586-026-10932-7 可能开放获取（PMC ID: PMC13626957） A
38 Endocannabinoids facilitate reward engagement through retrograde gain control. Nature 未提供 神经科学、遗传学与基因组学、药物研发 Research Article 42649292 10.1038/s41586-026-10967-w 可能开放获取（PMC ID: PMC13630341） A
39 Aberrant excitatory neuronal ERBB4 promotes Alzheimer's disease pathology. Nature 未提供 神经科学、免疫学、遗传学与基因组学 Research Article 42649291 10.1038/s41586-026-10964-z 可能开放获取（PMC ID: PMC13668712） A
40 Ultrafast and reference-free sequence discovery in single-cell data. Nature 未提供 神经科学、免疫学、细胞生物学 Research Article 42649290 10.1038/s41586-026-10975-w 非 OA / 需订阅访问 A
41 Automated prototyping of genetic codes. Nature 未提供 神经科学、遗传学与基因组学、结构生物学 Research Article 42649287 10.1038/s41586-026-10949-y 可能开放获取（PMC ID: PMC13645668） A
42 Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis. Nature 未提供 免疫学、细胞生物学、药物研发 Research Article 42649286 10.1038/s41586-026-10957-y 可能开放获取（PMC ID: PMC13645671） A
43 Pervasive phosphorylation by phage T7 kinase disarms bacterial defences. Nature 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42618789 10.1038/s41586-026-10934-5 可能开放获取（PMC ID: PMC13645617） A
44 A biased allosteric modulator is a molecular glue for β 2 AR dimerization. Nature 未提供 细胞生物学、结构生物学、药物研发 Research Article 42618785 10.1038/s41586-026-10892-y 可能开放获取（PMC ID: PMC13645619） A
45 In vivo genome-wide CRISPR screens of human T cells in solid tumours. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42587162 10.1038/s41586-026-10906-9 非 OA / 需订阅访问 A
46 Neural basis of compositional control. Nature 未提供 神经科学、人工智能 Research Article 42587159 10.1038/s41586-026-10896-8 非 OA / 需订阅访问 A
47 Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42587157 10.1038/s41586-026-10907-8 可能开放获取（PMC ID: PMC13531005） A
48 Biomarkers of nivolumab benefit in resectable non-small cell lung cancer. Nature 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42587156 10.1038/s41586-026-10925-6 可能开放获取（PMC ID: PMC13668692） A
49 Structural mechanism governing the directionality of bridge recombination. Nature 未提供 神经科学、遗传学与基因组学、结构生物学 Research Article 42587149 10.1038/s41586-026-10903-y 可能开放获取（PMC ID: PMC13626964） A
50 Rational design of disordered proteins for sequence-function investigation. Nature 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42527600 10.1038/s41586-026-10849-1 可能开放获取（PMC ID: PMC13575894） A
51 Base editing reveals an essential role for NANOG in human embryogenesis. Nature 未提供 免疫学、发育生物学、遗传学与基因组学 Research Article 42350792 10.1038/s41586-026-10792-1 可能开放获取（PMC ID: PMC13716833） A
52 Innate sensor responses set a supra-unitary threshold for viral replication. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42956738 10.1016/j.cell.2026.10.004 非 OA / 需订阅访问 A
53 Multimodal spatial transcriptomics redefines cortical pathology in Huntington's disease. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42950818 10.1016/j.cell.2026.09.064 非 OA / 需订阅访问 A
54 Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42914978 10.1016/j.cell.2026.09.062 非 OA / 需订阅访问 A
55 Cell-state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer. Cell 未提供 肿瘤学、细胞生物学、遗传学与基因组学 Research Article 42914976 10.1016/j.cell.2026.09.045 可能开放获取（PMC ID: PMC13718723） A
56 In vivo Gene Writing with engineered retrotransposons. Cell 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42906542 10.1016/j.cell.2026.09.054 非 OA / 需订阅访问 A
57 A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression. Cell 未提供 肿瘤学、遗传学与基因组学、药物研发 Research Article 42906540 10.1016/j.cell.2026.09.053 非 OA / 需订阅访问 A
58 Proteomic atlas of T cell exhaustion defines proteostatic collapse. Cell 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42906538 10.1016/j.cell.2026.09.051 可能开放获取（PMC ID: PMC13693510） A
59 A microbiome-bile acid axis mediates protection from chronic liver disease in females. Cell 未提供 细胞生物学、微生物/病毒、药物研发 Research Article 42896552 10.1016/j.cell.2026.09.048 非 OA / 需订阅访问 A
60 Mitochondria-targeted tetraoxanes initiate lipid peroxidation to drive ferroptosis and tumor suppression. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42880285 10.1016/j.cell.2026.09.040 非 OA / 需订阅访问 A
61 Multi-omics atlas of chronic exercise. Cell 未提供 神经科学、遗传学与基因组学、人工智能 Research Article 42880284 10.1016/j.cell.2026.09.044 非 OA / 需订阅访问 A
62 An opioid efficacy switch for reversible optical control of analgesia. Cell 未提供 神经科学、细胞生物学、药物研发 Research Article 42880283 10.1016/j.cell.2026.09.042 非 OA / 需订阅访问 A
63 Functional diversification of the cephalopod proteome by RNA editing. Cell 未提供 细胞生物学、遗传学与基因组学、蛋白质科学 Research Article 42880282 10.1016/j.cell.2026.09.043 可能开放获取（PMC ID: PMC13727390） A
64 Spatiotemporal co-transcriptomics uncovers coordinated rhizobia-legume stress programs supporting nitrogen fixation in Medicago. Cell 未提供 免疫学、发育生物学、细胞生物学 Research Article 42880234 10.1016/j.cell.2026.07.033 非 OA / 需订阅访问 A
65 Somatic epimutations cap genetic determinism in the human diploid chromatin epigenome. Cell 未提供 免疫学、发育生物学、遗传学与基因组学 Research Article 42880232 10.1016/j.cell.2026.09.034 可能开放获取（PMC ID: PMC13723045） A
66 Comprehensive benchmarking of somatic mutation detection by the SMaHT Network. Cell 未提供 遗传学与基因组学、人工智能、生物技术 Research Article 42880231 10.1016/j.cell.2026.09.037 非 OA / 需订阅访问 A
67 Cellular scaling laws in the mammalian brain. Cell 未提供 神经科学、细胞生物学、药物研发 Review 42880229 10.1016/j.cell.2026.08.044 非 OA / 需订阅访问 A
68 PTPRS mediates invasion of tetanus neurotoxin into the central nervous system. Cell 未提供 神经科学、药物研发、蛋白质科学 Research Article 42869022 10.1016/j.cell.2026.09.026 可能开放获取（PMC ID: PMC13690495） A
69 Immunoregulatory gene GIMAP6 suppresses lethal atherosclerotic vasculopathy and ischemic heart failure. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42849439 10.1016/j.cell.2026.09.032 可能开放获取（PMC ID: PMC13688317） A
70 A fluctuation test for gastruloid heterogeneity. Cell 未提供 神经科学、肿瘤学、发育生物学 Research Article 42849438 10.1016/j.cell.2026.09.057 非 OA / 需订阅访问 A
71 A spatiotemporal lifecycle atlas decodes spatial coordination in rice. Cell 未提供 发育生物学、遗传学与基因组学、蛋白质科学 Research Article 42838048 10.1016/j.cell.2026.09.023 非 OA / 需订阅访问 A
72 SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42838047 10.1016/j.cell.2026.09.021 非 OA / 需订阅访问 A
73 Comparative analysis of mitochondrial proteomes across the tree of life. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42822426 10.1016/j.cell.2026.08.029 非 OA / 需订阅访问 A
74 A high-confidence plant mitochondrial proteome via protein correlation profiling. Cell 未提供 细胞生物学、遗传学与基因组学、蛋白质科学 Research Article 42822425 10.1016/j.cell.2026.08.027 非 OA / 需订阅访问 A
75 Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen. Cell 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42822424 10.1016/j.cell.2026.08.056 可能开放获取（PMC ID: PMC13632651） A
76 Decoding mitochondrial proteomes of diverse eukaryotes. Cell 未提供 细胞生物学、遗传学与基因组学、人工智能 Research Article 42822423 10.1016/j.cell.2026.09.007 非 OA / 需订阅访问 A
77 Resident tissue macrophages transfer selenium transporter protein to protect pancreatic cancer from ferroptosis. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42785301 10.1016/j.cell.2026.09.001 非 OA / 需订阅访问 A
78 A geothermal amoeba sets a new upper temperature limit for eukaryotes. Cell 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42772279 10.1016/j.cell.2026.08.043 可能开放获取（PMC ID: PMC13598948） A
79 Toward autonomous science with agentic artificial intelligence. Cell 未提供 神经科学、遗传学与基因组学、结构生物学 Review 42753735 10.1016/j.cell.2026.08.052 非 OA / 需订阅访问 A
80 Caloric restriction modulates genome-wide somatic mutation in mice. Cell 未提供 神经科学、遗传学与基因组学、人工智能 Research Article 42716011 10.1016/j.cell.2026.08.013 可能开放获取（PMC ID: PMC13559707） A
81 De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles. Cell 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42679818 10.1016/j.cell.2026.08.007 非 OA / 需订阅访问 A
82 Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to promote goal-directed action. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42673964 10.1016/j.cell.2026.07.058 可能开放获取（PMC ID: PMC13637798） A
83 RNA structures regulate norovirus life cycle and enable rational attenuation in vivo. Cell 未提供 神经科学、免疫学、遗传学与基因组学 Research Article 42617594 10.1016/j.cell.2026.07.051 可能开放获取（PMC ID: PMC13586799） A
84 Convergent evolution of metabolic regulation governs redox adaptation in Toxoplasma. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42580337 10.1016/j.cell.2026.07.029 可能开放获取（PMC ID: PMC13531851） A
85 The structural basis for LRRK2's activation and autoinhibition. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42575089 10.1016/j.cell.2026.07.027 可能开放获取（PMC ID: PMC13632595） A
86 Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions. Cell 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42551423 10.1016/j.cell.2026.07.023 可能开放获取（PMC ID: PMC13537306） A
87 Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration. Cell 未提供 神经科学、肿瘤学、发育生物学 Research Article 42546689 10.1016/j.cell.2026.07.026 非 OA / 需订阅访问 A
88 CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42526438 10.1016/j.cell.2026.07.016 非 OA / 需订阅访问 A
89 Diet at disease onset determines tissue inflammatory memory. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42957863 10.1038/s41586-026-11181-4 非 OA / 需订阅访问 B
90 Alzheimer's disease genetics converges on microglial and neuronal dysregulation. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42951976 10.1038/s41586-026-11206-y 非 OA / 需订阅访问 B
91 Tandem repeat variation shapes immune cell type-specific gene expression. Nature 未提供 免疫学、遗传学与基因组学、生物技术 Research Article 42951975 10.1038/s41586-026-10438-2 非 OA / 需订阅访问 B
92 Rare and common genetic variants shape single-cell immune gene expression. Nature 未提供 免疫学、遗传学与基因组学、生物技术 Research Article 42951973 10.1038/s41586-026-10721-2 非 OA / 需订阅访问 B
93 Emotion regulation capacity lacks a shared neural signature. Nature 未提供 神经科学、遗传学与基因组学、药物研发 Research Article 42951968 10.1038/s41586-026-11203-1 非 OA / 需订阅访问 B
94 Eukaryotes' closest relatives are internally simple syntrophic peptidotrophic archaea. Nature 未提供 细胞生物学、遗传学与基因组学 Research Article 42951967 10.1038/s41586-026-11170-7 非 OA / 需订阅访问 B
95 Perinatal elimination of genetically aberrant human cortical neurons. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42951966 10.1038/s41586-026-11190-3 非 OA / 需订阅访问 B
96 Tumour assembloids recapitulate tumour-CAF-T cell crosstalk in renal cancer. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42951965 10.1038/s41586-026-11208-w 非 OA / 需订阅访问 B
97 T and B cells recognize splicing-derived neutrophil neoantigens in lupus. Nature 未提供 免疫学、遗传学与基因组学、蛋白质科学 Research Article 42951964 10.1038/s41586-026-11219-7 非 OA / 需订阅访问 B
98 SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin. Nature 未提供 肿瘤学、遗传学与基因组学 Research Article 42951962 10.1038/s41586-026-11197-w 非 OA / 需订阅访问 B
99 Presynaptic homeostasis mediated by exocytosis of a SNARE protein. Nature 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42951961 10.1038/s41586-026-11201-3 非 OA / 需订阅访问 B
100 Clostridium perfringens Delta toxin targets CD9 to drive NEC and brain injury. Nature 未提供 神经科学、免疫学、发育生物学 Research Article 42951958 10.1038/s41586-026-11211-1 非 OA / 需订阅访问 B
101 Molecular underpinnings of rheumatic diseases and emerging therapeutic concepts. Nature 未提供 免疫学、药物研发 Review 42951953 10.1038/s41586-026-10966-x 非 OA / 需订阅访问 B
102 ctDNA clearance and outcomes for resectable lung cancer from NeoCOAST-2. Nature 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42927884 10.1038/s41586-026-11328-3 非 OA / 需订阅访问 B
103 Multimodal precision diagnostics in clinical xenotransplantation. Nature 未提供 免疫学、发育生物学、遗传学与基因组学 Review 42907518 10.1038/s41586-026-11096-0 非 OA / 需订阅访问 B
104 Persistent neuronal stress signalling underlies Angelman syndrome phenotypes. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42907508 10.1038/s41586-026-11165-4 非 OA / 需订阅访问 B
105 Cold activates a BH2 metabolic network promoting longevity and proteostasis. Nature 未提供 神经科学、遗传学与基因组学、蛋白质科学 Research Article 42907506 10.1038/s41586-026-11152-9 非 OA / 需订阅访问 B
106 WEE1 opposes APC/C CDH1 activity to promote S phase entry. Nature 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42907504 10.1038/s41586-026-11188-x 非 OA / 需订阅访问 B
107 Structural basis for protocadherin-1 recognition by New World hantaviruses. Nature 未提供 神经科学、免疫学、遗传学与基因组学 Research Article 42907501 10.1038/s41586-026-11184-1 非 OA / 需订阅访问 B
108 CD51 delineates functionally distinct astrocyte subtypes in neural circuits. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42907500 10.1038/s41586-026-11186-z 非 OA / 需订阅访问 B
109 An environmentally regulated dichotomy in cell lineages of the root. Nature 未提供 免疫学、发育生物学、遗传学与基因组学 Research Article 42907499 10.1038/s41586-026-11179-y 非 OA / 需订阅访问 B
110 De novo design of enantioselective artificial metalloenzyme photocatalysts. Nature 未提供 遗传学与基因组学、蛋白质科学 Research Article 42906913 10.1038/s41586-026-11317-6 非 OA / 需订阅访问 B
111 Cortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes. Nature 未提供 神经科学、细胞生物学 Research Article 42896839 10.1038/s41586-026-11293-x 非 OA / 需订阅访问 B
112 Sexual dimorphism in epidermal stem cell dynamics. Nature 未提供 发育生物学、遗传学与基因组学、生物技术 Research Article 42875501 10.1038/s41586-026-11159-2 非 OA / 需订阅访问 B
113 Modelling mouse embryogenesis from chemically induced totipotent stem cells. Nature 未提供 发育生物学、细胞生物学、遗传学与基因组学 Research Article 42875493 10.1038/s41586-026-11164-5 非 OA / 需订阅访问 B
114 Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades. Nature 未提供 药物研发 Research Article 42875490 10.1038/s41586-026-11171-6 非 OA / 需订阅访问 B
115 Divergent genomic evolution in astrocytomas and oligodendrogliomas. Nature 未提供 神经科学、肿瘤学、遗传学与基因组学 Research Article 42875489 10.1038/s41586-026-11150-x 非 OA / 需订阅访问 B
116 Prehistoric global migration of vanishing gut microbes with humans. Nature 未提供 遗传学与基因组学、微生物/病毒 Research Article 42844483 10.1038/s41586-026-11106-1 可能开放获取（PMC ID: PMC13686943） B
117 Human lung organoid modelling of tissue-resident antiviral T cell responses. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42844476 10.1038/s41586-026-11114-1 非 OA / 需订阅访问 B
118 Cryo-EM structure of a methanogen nitrogenase-PII protein supercomplex. Nature 未提供 细胞生物学、结构生物学、微生物/病毒 Research Article 42844472 10.1038/s41586-026-11116-z 非 OA / 需订阅访问 B
119 5-oxoETE links redox control of epithelial damage detection and resilience. Nature 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42844471 10.1038/s41586-026-11121-2 非 OA / 需订阅访问 B
120 Structural basis for regulating lipopolysaccharide transmembrane transport. Nature 未提供 细胞生物学、微生物/病毒、蛋白质科学 Research Article 42844470 10.1038/s41586-026-11129-8 非 OA / 需订阅访问 B
121 Alveolar stem cells transdifferentiate to drive bronchiolar regeneration. Nature 未提供 免疫学、发育生物学、细胞生物学 Research Article 42844469 10.1038/s41586-026-11127-w 非 OA / 需订阅访问 B
122 Dynamics of human cardiogenesis and its disruption in trisomy 21. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42844467 10.1038/s41586-026-11125-y 可能开放获取（PMC ID: PMC13716840） B
123 RNA catalysis emerges from dynamic structural ensembles. Nature 未提供 遗传学与基因组学、结构生物学、蛋白质科学 Research Article 42844466 10.1038/s41586-026-11140-z 非 OA / 需订阅访问 B
124 Overcoming key challenges in the evolutionary transition to multicellularity. Nature 未提供 发育生物学、细胞生物学、微生物/病毒 Review 42844412 10.1038/s41586-026-11038-w 非 OA / 需订阅访问 B
125 Sugar-rich foods exacerbate antibiotic-induced microbiome disruption. Nature 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42816625 10.1038/s41586-026-11077-3 可能开放获取（PMC ID: PMC13668661） B
126 Osteoclasts intercept meningeal lymphatic paths for dural metastasis. Nature 未提供 神经科学、免疫学、肿瘤学 Research Article 42816624 10.1038/s41586-026-11082-6 非 OA / 需订阅访问 B
127 A two-hit mechanism triggers autoimmune hair loss. Nature 未提供 神经科学、免疫学、发育生物学 Research Article 42816609 10.1038/s41586-026-11098-y 非 OA / 需订阅访问 B
128 The gene-regulatory evolution of the human skeleton. Nature 未提供 细胞生物学、遗传学与基因组学 Research Article 42778609 10.1038/s41586-026-11053-x 可能开放获取（PMC ID: PMC13668659） B
129 Reference genomes and fossils revise bat family phylogeny and biogeography. Nature 未提供 遗传学与基因组学 Research Article 42778608 10.1038/s41586-026-11007-3 可能开放获取（PMC ID: PMC13626947） B
130 The lipidomic architecture of the mouse brain. Nature 未提供 神经科学、发育生物学、细胞生物学 Research Article 42778605 10.1038/s41586-026-11050-0 可能开放获取（PMC ID: PMC13626954） B
131 A methanogen hydrolase reveals the structure of archaeal peptidoglycan. Nature 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42778595 10.1038/s41586-026-11028-y 非 OA / 需订阅访问 B
132 Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila. Nature 未提供 遗传学与基因组学、药物研发、蛋白质科学 Research Article 42778591 10.1038/s41586-026-11029-x 非 OA / 需订阅访问 B
133 Developmental xenocortication using human-derived organoids in mice. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42749812 10.1038/s41586-026-11032-2 可能开放获取（PMC ID: PMC13645680） B
134 Development of a random background to understand ligand optimization. Nature 未提供 发育生物学、药物研发 Research Article 42749805 10.1038/s41586-026-11013-5 可能开放获取（PMC ID: PMC13716815） B
135 Mitochondrial fission factor senses and governs ferroptosis. Nature 未提供 细胞生物学、蛋白质科学 Research Article 42749797 10.1038/s41586-026-11020-6 非 OA / 需订阅访问 B
136 Highly efficient base editing at PCSK9 and normal human embryo development. Nature 未提供 发育生物学、遗传学与基因组学、药物研发 Research Article 42742174 10.1038/s41586-026-11118-x 非 OA / 需订阅访问 B
137 PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity. Nature 未提供 免疫学、肿瘤学、发育生物学 Research Article 42717091 10.1038/s41586-026-10954-1 可能开放获取（PMC ID: PMC13645638） B
138 A serpin-myeloid axis in pancreatic cancer heterogeneity and immune evasion. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42717081 10.1038/s41586-026-11002-8 可能开放获取（PMC ID: PMC13716829） B
139 Robust inference and correlates from genetic associations with personality. Nature 未提供 遗传学与基因组学、药物研发 Meta-Analysis 42686911 10.1038/s41586-026-10992-9 可能开放获取（PMC ID: PMC13589609） B
140 Intracellular complement factor H protects neurons during CNS inflammation. Nature 未提供 神经科学、免疫学、细胞生物学 Research Article 42686909 10.1038/s41586-026-10981-y 可能开放获取（PMC ID: PMC13668678） B
141 Somatic mutations reveal the ontogeny of microglia in human ageing. Nature 未提供 神经科学、免疫学、发育生物学 Research Article 42686898 10.1038/s41586-026-10939-0 非 OA / 需订阅访问 B
142 Wake-activated neuronal populations that regulate sleep drive. Nature 未提供 神经科学、药物研发 Research Article 42618797 10.1038/s41586-026-10928-3 可能开放获取（PMC ID: PMC13686944） B
143 Family genetic designs in MoBa provide insights into health and functioning. Nature 未提供 神经科学、遗传学与基因组学 Research Article 42618792 10.1038/s41586-026-10926-5 可能开放获取（PMC ID: PMC13668695） B
144 Functional role of skull lymphoid structures in CNS immunosurveillance. Nature 未提供 神经科学、免疫学、肿瘤学 Research Article 42618784 10.1038/s41586-026-10951-4 可能开放获取（PMC ID: PMC13626955） B
145 An Icelandic pangenome reference. Nature 未提供 神经科学、遗传学与基因组学、微生物/病毒 Research Article 42618781 10.1038/s41586-026-10924-7 可能开放获取（PMC ID: PMC13645673） B
146 Maternal influences on infant gut microbiome and health. Nature 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42587158 10.1038/s41586-026-10922-9 可能开放获取（PMC ID: PMC13626959） B
147 Temporal uncoupling of radial glia lineage progression in cortical organoids. Nature 未提供 神经科学、发育生物学、遗传学与基因组学 Research Article 42587153 10.1038/s41586-026-10916-7 可能开放获取（PMC ID: PMC13668663） B
148 A cholinergic hub in the nucleus accumbens gates opioid-reward learning. Nature 未提供 神经科学、遗传学与基因组学、药物研发 Research Article 42557321 10.1038/s41586-026-10887-9 可能开放获取（PMC ID: PMC13454963） B
149 Membranolytic peptide programs immunogenic cell death for cancer therapy. Nature 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42557318 10.1038/s41586-026-10899-5 非 OA / 需订阅访问 B
150 Age-dependent structural evolution of a functional amyloid contributes to memory impairment in Drosophila. Cell 未提供 神经科学 Research Article 42962658 10.1016/j.cell.2026.10.009 非 OA / 需订阅访问 B
151 Roads not taken: The mismatch between safety and regulation of plant breeding innovation. Cell 未提供 免疫学、遗传学与基因组学、蛋白质科学 Research Article 42956714 10.1016/j.cell.2026.09.018 非 OA / 需订阅访问 B
152 Somatic DNA-repeat expansions initiate distinct yet analogous changes in Huntington's disease cortical and striatal neurons. Cell 未提供 神经科学、遗传学与基因组学、微生物/病毒 Research Article 42950817 10.1016/j.cell.2026.10.001 非 OA / 需订阅访问 B
153 Deep sequencing of 3,367 maize genomes uncovers substantial contribution of rare variants to agronomic traits. Cell 未提供 遗传学与基因组学 Research Article 42945956 10.1016/j.cell.2026.09.063 非 OA / 需订阅访问 B
154 In vivo genome-editing therapy for Duchenne muscular dystrophy: Preclinical studies and first-in-human trial. Cell 未提供 免疫学、遗传学与基因组学、微生物/病毒 Research Article 42933389 10.1016/j.cell.2026.09.059 非 OA / 需订阅访问 B
155 Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42913630 10.1016/j.cell.2026.09.055 可能开放获取（PMC ID: PMC13734568） B
156 The pyrin inflammasome senses OCTN2-mediated uptake of extracellular ʟ-carnitine from muscle injury or ingestion. Cell 未提供 免疫学、细胞生物学 Research Article 42896553 10.1016/j.cell.2026.09.015 非 OA / 需订阅访问 B
157 A phenome-wide structural variant map from 467,152 UK Biobank genomes. Cell 未提供 遗传学与基因组学、药物研发、蛋白质科学 Research Article 42880286 10.1016/j.cell.2026.09.035 非 OA / 需订阅访问 B
158 Cellular self-organization orchestrates ferroptosis propagation. Cell 未提供 免疫学、发育生物学、细胞生物学 Research Article 42880281 10.1016/j.cell.2026.09.039 非 OA / 需订阅访问 B
159 A telomere-to-telomere map of somatic mutation burden and functional impact in a cancer. Cell 未提供 肿瘤学、遗传学与基因组学 Research Article 42880233 10.1016/j.cell.2026.09.033 可能开放获取（PMC ID: PMC13722029） B
160 Charting the silent variation within us. Cell 未提供 发育生物学、遗传学与基因组学 Research Article 42880230 10.1016/j.cell.2026.09.046 非 OA / 需订阅访问 B
161 A pseudoenzyme sensor of trehalose-6-phosphate directly represses the metabolic integrator SnRK1 in plants. Cell 未提供 细胞生物学、遗传学与基因组学、结构生物学 Research Article 42874590 10.1016/j.cell.2026.09.016 非 OA / 需订阅访问 B
162 A high-dimensional population code in the bat motor cortex during natural dexterous flight. Cell 未提供 神经科学 Research Article 42869023 10.1016/j.cell.2026.09.029 非 OA / 需订阅访问 B
163 Mechanisms of transcription control by distal enhancers from single-gene nanoscopy. Cell 未提供 遗传学与基因组学、药物研发 Research Article 42869021 10.1016/j.cell.2026.09.028 非 OA / 需订阅访问 B
164 Rare k-mers reveal centromere haplogroups underlying human diversity and cancer translocations. Cell 未提供 神经科学、肿瘤学、遗传学与基因组学 Research Article 42869020 10.1016/j.cell.2026.08.053 非 OA / 需订阅访问 B
165 Mapping transcriptional responses to cellular perturbations with RNA fingerprinting. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42854686 10.1016/j.cell.2026.09.017 非 OA / 需订阅访问 B
166 Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesis. Cell 未提供 神经科学、发育生物学、细胞生物学 Research Article 42849436 10.1016/j.cell.2026.09.050 可能开放获取（PMC ID: PMC13722109） B
167 A non-canonical function of glutathione to suppress ferroptosis via FSP1. Cell 未提供 遗传学与基因组学、药物研发、蛋白质科学 Research Article 42838049 10.1016/j.cell.2026.09.024 非 OA / 需订阅访问 B
168 Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis. Cell 未提供 免疫学、肿瘤学、发育生物学 Research Article 42838046 10.1016/j.cell.2026.09.020 非 OA / 需订阅访问 B
169 STING reprogramming by estrogen promotes neutrophil extracellular trap formation and sex-biased resistance to ADC therapy. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42838045 10.1016/j.cell.2026.09.031 非 OA / 需订阅访问 B
170 Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS. Cell 未提供 细胞生物学、微生物/病毒、蛋白质科学 Research Article 42822427 10.1016/j.cell.2026.08.057 可能开放获取（PMC ID: PMC13632647） B
171 Opposing functions of gut immunomodulatory metabolites on CAR-T therapy. Cell 未提供 免疫学、肿瘤学、遗传学与基因组学 Research Article 42805174 10.1016/j.cell.2026.09.004 非 OA / 需订阅访问 B
172 Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42772280 10.1016/j.cell.2026.08.049 非 OA / 需订阅访问 B
173 Oligodendrocytes in central nervous system health and disease. Cell 未提供 神经科学、发育生物学、细胞生物学 Review 42759515 10.1016/j.cell.2026.08.003 非 OA / 需订阅访问 B
174 Copper ion-induced MYH9 polymerization executes cuproptosis. Cell 未提供 免疫学、肿瘤学、细胞生物学 Research Article 42735689 10.1016/j.cell.2026.08.030 非 OA / 需订阅访问 B
175 Glycocalyx-edited mesenchymal stem/stromal cell therapy in advanced osteoporosis. Cell 未提供 发育生物学、遗传学与基因组学、药物研发 Clinical Trial 42727576 10.1016/j.cell.2026.08.017 非 OA / 需订阅访问 B
176 Metax enables accurate cross-domain taxonomic profiling of metagenomes. Cell 未提供 遗传学与基因组学、微生物/病毒 Research Article 42727575 10.1016/j.cell.2026.08.024 非 OA / 需订阅访问 B
177 Identification of the tendon/ligament stem cell in mice and humans. Cell 未提供 发育生物学、细胞生物学、遗传学与基因组学 Research Article 42705230 10.1016/j.cell.2026.08.018 非 OA / 需订阅访问 B
178 Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types. Cell 未提供 细胞生物学、遗传学与基因组学、生物技术 Research Article 42685689 10.1016/j.cell.2026.08.010 非 OA / 需订阅访问 B
179 Live-cell transcriptomics with engineered virus-like particles. Cell 未提供 免疫学、发育生物学、细胞生物学 Research Article 42679822 10.1016/j.cell.2026.08.005 可能开放获取（PMC ID: PMC13618706） B
180 Ratiometric transcriptional activation by protein degradation. Cell 未提供 细胞生物学、遗传学与基因组学、药物研发 Research Article 42679820 10.1016/j.cell.2026.08.009 非 OA / 需订阅访问 B
181 Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42679819 10.1016/j.cell.2026.08.006 可能开放获取（PMC ID: PMC13653636） B
182 Genome-scale perturb-seq in primary human CD4 + T cells maps context-specific regulators of T cell programs and human immune traits. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42664972 10.1016/j.cell.2026.08.002 可能开放获取（PMC ID: PMC13614707） B
183 Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling. Cell 未提供 免疫学、遗传学与基因组学 Research Article 42664971 10.1016/j.cell.2026.07.053 可能开放获取（PMC ID: PMC13629392） B
184 Integrative spatial profiling of 3D genome organization and gene expression in tissue. Cell 未提供 神经科学、肿瘤学、发育生物学 Research Article 42641604 10.1016/j.cell.2026.07.039 可能开放获取（PMC ID: PMC13509204） B
185 DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development. Cell 未提供 神经科学、免疫学、发育生物学 Research Article 42636811 10.1016/j.cell.2026.07.041 非 OA / 需订阅访问 B
186 Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits. Cell 未提供 细胞生物学、遗传学与基因组学、微生物/病毒 Research Article 42617596 10.1016/j.cell.2026.07.055 非 OA / 需订阅访问 B
187 Multimodal brain cell atlas across the adult macaque lifespan. Cell 未提供 神经科学、细胞生物学、遗传学与基因组学 Research Article 42612631 10.1016/j.cell.2026.07.045 非 OA / 需订阅访问 B
188 Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human. Cell 未提供 神经科学、免疫学、肿瘤学 Research Article 42600613 10.1016/j.cell.2026.07.043 可能开放获取（PMC ID: PMC13546755） B
189 Functional atlas of vertebrate viral RNA elements that stabilize RNA and enhance translation. Cell 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42594865 10.1016/j.cell.2026.07.038 非 OA / 需订阅访问 B
190 Co-option of retrotransposons promotes antibody diversification. Cell 未提供 免疫学、遗传学与基因组学、药物研发 Research Article 42546688 10.1016/j.cell.2026.07.021 可能开放获取（PMC ID: PMC13656868） B
191 Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance. Cell 未提供 免疫学、发育生物学、遗传学与基因组学 Research Article 42546687 10.1016/j.cell.2026.07.022 非 OA / 需订阅访问 B
192 Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation. Cell 未提供 免疫学、细胞生物学、遗传学与基因组学 Research Article 42526439 10.1016/j.cell.2026.07.011 非 OA / 需订阅访问 B
193 An Oryza orphan gene confers trans-species drought tolerance. Cell 未提供 细胞生物学、遗传学与基因组学、蛋白质科学 Research Article 42492508 10.1016/j.cell.2026.07.005 非 OA / 需订阅访问 B
194 Trichoderma swollenin activates AtABCB5-dependent auxin efflux to promote plant development. Cell 未提供 免疫学、发育生物学、细胞生物学 Research Article 42492507 10.1016/j.cell.2026.07.001 非 OA / 需订阅访问 B
195 Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development. Cell 未提供 免疫学、发育生物学、遗传学与基因组学 Research Article 42486083 10.1016/j.cell.2026.07.006 非 OA / 需订阅访问 B
196 Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context. Cell 未提供 遗传学与基因组学、微生物/病毒、药物研发 Research Article 42468524 10.1016/j.cell.2026.06.033 可能开放获取（PMC ID: PMC13437135） B
197 Drought and disease trigger novel interactions among top predators. Nature 未提供 生物学 Research Article 42907515 10.1038/s41586-026-11194-z 非 OA / 需订阅访问 C
198 The anthropogenic fingerprint on emerging infectious diseases. Nature 未提供 微生物/病毒、人工智能 Research Article 42778602 10.1038/s41586-026-11058-6 可能开放获取（PMC ID: PMC13716837） C
199 Toward planetary microbial systems biology. Cell 未提供 细胞生物学、微生物/病毒、人工智能 Review 42956717 10.1016/j.cell.2026.09.019 非 OA / 需订阅访问 C
200 Mutually beneficial interactions between bacteria and Arabidopsis promote phosphorus nutrition and growth. Cell 未提供 微生物/病毒 Research Article 42612632 10.1016/j.cell.2026.07.048 非 OA / 需订阅访问 C

二、按期刊分类列表

Nature

  • PMID 42951971 — Connectome simulations identify a central pattern generator for fly walking. (Research Article, 推荐等级 A)
  • PMID 42951970 — Genetic variants shape single-cell chromatin accessibility and disease risk. (Research Article, 推荐等级 A)
  • PMID 42951963 — Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers. (Research Article, 推荐等级 A)
  • PMID 42907516 — Programmable design of functional proteins from natural language. (Research Article, 推荐等级 A)
  • PMID 42907503 — GRP75-dependent SIMPA mediates inter-organellar quality control. (Research Article, 推荐等级 A)
  • PMID 42875502 — A microexon regulatory code reveals autism-linked genetic variation. (Research Article, 推荐等级 A)
  • PMID 42875499 — Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism. (Research Article, 推荐等级 A)
  • PMID 42875495 — Elp1 is required for myeloid differentiation and brain repopulation. (Research Article, 推荐等级 A)
  • PMID 42875491 — Artificial intelligence-enabled clinical phenotyping of human brown fat. (Research Article, 推荐等级 A)
  • PMID 42875488 — De novo design of cysteine proteases. (Research Article, 推荐等级 A)
  • PMID 42875487 — Computational design of metalloproteases. (Research Article, 推荐等级 A)
  • PMID 42863825 — Antiviral immunity via telomerase-like reverse transcription in bacteria. (Research Article, 推荐等级 A)
  • PMID 42844481 — A preinvasive regulatory T cell axis for lung cancer interception. (Research Article, 推荐等级 A)
  • PMID 42844478 — Retrofitting language models to operate over bytes. (Research Article, 推荐等级 A)
  • PMID 42844473 — A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice. (Research Article, 推荐等级 A)
  • PMID 42844465 — tRNA dosage regulates lineage dependency and resistance in prostate cancer. (Research Article, 推荐等级 A)
  • PMID 42844464 — A split attractor design for rapidly writing a navigational goal. (Research Article, 推荐等级 A)
  • PMID 42816618 — Dynamic protrusions mediate crawling motility in Asgard archaea. (Research Article, 推荐等级 A)
  • PMID 42816607 — Prion-like transmission of human tau strains in the mouse brain. (Research Article, 推荐等级 A)
  • PMID 42816559 — Written in development and lost in ageing: the grammar of cellular identity. (Review, 推荐等级 A)
  • PMID 42778593 — MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness. (Research Article, 推荐等级 A)
  • PMID 42778590 — Lsp2 links early-life diet to adult translation and lifespan in Drosophila. (Research Article, 推荐等级 A)
  • PMID 42749808 — Reimagining research papers as interactive and reliable AI agents. (Research Article, 推荐等级 A)
  • PMID 42749806 — Cohesin reshapes replication fork contacts to aid fork slowing and reversal. (Research Article, 推荐等级 A)
  • PMID 42749798 — Mutational constraints on RSV F and its neutralization by antibodies. (Research Article, 推荐等级 A)
  • PMID 42742167 — Learning millisecond protein dynamics from what is missing in NMR spectra. (Research Article, 推荐等级 A)
  • PMID 42717098 — An operational perturbation proteomics-based virtual cell model. (Research Article, 推荐等级 A)
  • PMID 42717095 — Imaging cellular activity across all organs reveals body-wide circuits. (Research Article, 推荐等级 A)
  • PMID 42717093 — TRI-611, a selective, brain-penetrant molecular glue degrader of ALK. (Research Article, 推荐等级 A)
  • PMID 42717092 — Proximity-guided graph learning reveals tumour-associated proximity antigens. (Research Article, 推荐等级 A)
  • PMID 42686912 — Functional chimeric mRNAs encode proteins in mammalian immunity. (Research Article, 推荐等级 A)
  • PMID 42686908 — Creating bottom-up RNA transfer vehicles from synthetic protein assemblies. (Research Article, 推荐等级 A)
  • PMID 42686907 — 3D epigenome of glial cell types in developing human cortex. (Research Article, 推荐等级 A)
  • PMID 42686903 — Structure and operating principles of a monkeypox virus replisome. (Research Article, 推荐等级 A)
  • PMID 42686901 — Rewiring the ribosome to translate proteins encoded in its own RNA. (Research Article, 推荐等级 A)
  • PMID 42649302 — A binding-to-release strategy for targeted anticancer drug delivery. (Research Article, 推荐等级 A)
  • PMID 42649300 — Insights into longevity and virus-driven adaptation from Myotis bat genomes. (Research Article, 推荐等级 A)
  • PMID 42649292 — Endocannabinoids facilitate reward engagement through retrograde gain control. (Research Article, 推荐等级 A)
  • PMID 42649291 — Aberrant excitatory neuronal ERBB4 promotes Alzheimer's disease pathology. (Research Article, 推荐等级 A)
  • PMID 42649290 — Ultrafast and reference-free sequence discovery in single-cell data. (Research Article, 推荐等级 A)
  • PMID 42649287 — Automated prototyping of genetic codes. (Research Article, 推荐等级 A)
  • PMID 42649286 — Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis. (Research Article, 推荐等级 A)
  • PMID 42618789 — Pervasive phosphorylation by phage T7 kinase disarms bacterial defences. (Research Article, 推荐等级 A)
  • PMID 42618785 — A biased allosteric modulator is a molecular glue for β 2 AR dimerization. (Research Article, 推荐等级 A)
  • PMID 42587162 — In vivo genome-wide CRISPR screens of human T cells in solid tumours. (Research Article, 推荐等级 A)
  • PMID 42587159 — Neural basis of compositional control. (Research Article, 推荐等级 A)
  • PMID 42587157 — Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders. (Research Article, 推荐等级 A)
  • PMID 42587156 — Biomarkers of nivolumab benefit in resectable non-small cell lung cancer. (Research Article, 推荐等级 A)
  • PMID 42587149 — Structural mechanism governing the directionality of bridge recombination. (Research Article, 推荐等级 A)
  • PMID 42527600 — Rational design of disordered proteins for sequence-function investigation. (Research Article, 推荐等级 A)
  • PMID 42350792 — Base editing reveals an essential role for NANOG in human embryogenesis. (Research Article, 推荐等级 A)
  • PMID 42957863 — Diet at disease onset determines tissue inflammatory memory. (Research Article, 推荐等级 B)
  • PMID 42951976 — Alzheimer's disease genetics converges on microglial and neuronal dysregulation. (Research Article, 推荐等级 B)
  • PMID 42951975 — Tandem repeat variation shapes immune cell type-specific gene expression. (Research Article, 推荐等级 B)
  • PMID 42951973 — Rare and common genetic variants shape single-cell immune gene expression. (Research Article, 推荐等级 B)
  • PMID 42951968 — Emotion regulation capacity lacks a shared neural signature. (Research Article, 推荐等级 B)
  • PMID 42951967 — Eukaryotes' closest relatives are internally simple syntrophic peptidotrophic archaea. (Research Article, 推荐等级 B)
  • PMID 42951966 — Perinatal elimination of genetically aberrant human cortical neurons. (Research Article, 推荐等级 B)
  • PMID 42951965 — Tumour assembloids recapitulate tumour-CAF-T cell crosstalk in renal cancer. (Research Article, 推荐等级 B)
  • PMID 42951964 — T and B cells recognize splicing-derived neutrophil neoantigens in lupus. (Research Article, 推荐等级 B)
  • PMID 42951962 — SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin. (Research Article, 推荐等级 B)
  • PMID 42951961 — Presynaptic homeostasis mediated by exocytosis of a SNARE protein. (Research Article, 推荐等级 B)
  • PMID 42951958 — Clostridium perfringens Delta toxin targets CD9 to drive NEC and brain injury. (Research Article, 推荐等级 B)
  • PMID 42951953 — Molecular underpinnings of rheumatic diseases and emerging therapeutic concepts. (Review, 推荐等级 B)
  • PMID 42927884 — ctDNA clearance and outcomes for resectable lung cancer from NeoCOAST-2. (Research Article, 推荐等级 B)
  • PMID 42907518 — Multimodal precision diagnostics in clinical xenotransplantation. (Review, 推荐等级 B)
  • PMID 42907508 — Persistent neuronal stress signalling underlies Angelman syndrome phenotypes. (Research Article, 推荐等级 B)
  • PMID 42907506 — Cold activates a BH2 metabolic network promoting longevity and proteostasis. (Research Article, 推荐等级 B)
  • PMID 42907504 — WEE1 opposes APC/C CDH1 activity to promote S phase entry. (Research Article, 推荐等级 B)
  • PMID 42907501 — Structural basis for protocadherin-1 recognition by New World hantaviruses. (Research Article, 推荐等级 B)
  • PMID 42907500 — CD51 delineates functionally distinct astrocyte subtypes in neural circuits. (Research Article, 推荐等级 B)
  • PMID 42907499 — An environmentally regulated dichotomy in cell lineages of the root. (Research Article, 推荐等级 B)
  • PMID 42906913 — De novo design of enantioselective artificial metalloenzyme photocatalysts. (Research Article, 推荐等级 B)
  • PMID 42896839 — Cortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes. (Research Article, 推荐等级 B)
  • PMID 42875501 — Sexual dimorphism in epidermal stem cell dynamics. (Research Article, 推荐等级 B)
  • PMID 42875493 — Modelling mouse embryogenesis from chemically induced totipotent stem cells. (Research Article, 推荐等级 B)
  • PMID 42875490 — Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades. (Research Article, 推荐等级 B)
  • PMID 42875489 — Divergent genomic evolution in astrocytomas and oligodendrogliomas. (Research Article, 推荐等级 B)
  • PMID 42844483 — Prehistoric global migration of vanishing gut microbes with humans. (Research Article, 推荐等级 B)
  • PMID 42844476 — Human lung organoid modelling of tissue-resident antiviral T cell responses. (Research Article, 推荐等级 B)
  • PMID 42844472 — Cryo-EM structure of a methanogen nitrogenase-PII protein supercomplex. (Research Article, 推荐等级 B)
  • PMID 42844471 — 5-oxoETE links redox control of epithelial damage detection and resilience. (Research Article, 推荐等级 B)
  • PMID 42844470 — Structural basis for regulating lipopolysaccharide transmembrane transport. (Research Article, 推荐等级 B)
  • PMID 42844469 — Alveolar stem cells transdifferentiate to drive bronchiolar regeneration. (Research Article, 推荐等级 B)
  • PMID 42844467 — Dynamics of human cardiogenesis and its disruption in trisomy 21. (Research Article, 推荐等级 B)
  • PMID 42844466 — RNA catalysis emerges from dynamic structural ensembles. (Research Article, 推荐等级 B)
  • PMID 42844412 — Overcoming key challenges in the evolutionary transition to multicellularity. (Review, 推荐等级 B)
  • PMID 42816625 — Sugar-rich foods exacerbate antibiotic-induced microbiome disruption. (Research Article, 推荐等级 B)
  • PMID 42816624 — Osteoclasts intercept meningeal lymphatic paths for dural metastasis. (Research Article, 推荐等级 B)
  • PMID 42816609 — A two-hit mechanism triggers autoimmune hair loss. (Research Article, 推荐等级 B)
  • PMID 42778609 — The gene-regulatory evolution of the human skeleton. (Research Article, 推荐等级 B)
  • PMID 42778608 — Reference genomes and fossils revise bat family phylogeny and biogeography. (Research Article, 推荐等级 B)
  • PMID 42778605 — The lipidomic architecture of the mouse brain. (Research Article, 推荐等级 B)
  • PMID 42778595 — A methanogen hydrolase reveals the structure of archaeal peptidoglycan. (Research Article, 推荐等级 B)
  • PMID 42778591 — Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila. (Research Article, 推荐等级 B)
  • PMID 42749812 — Developmental xenocortication using human-derived organoids in mice. (Research Article, 推荐等级 B)
  • PMID 42749805 — Development of a random background to understand ligand optimization. (Research Article, 推荐等级 B)
  • PMID 42749797 — Mitochondrial fission factor senses and governs ferroptosis. (Research Article, 推荐等级 B)
  • PMID 42742174 — Highly efficient base editing at PCSK9 and normal human embryo development. (Research Article, 推荐等级 B)
  • PMID 42717091 — PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity. (Research Article, 推荐等级 B)
  • PMID 42717081 — A serpin-myeloid axis in pancreatic cancer heterogeneity and immune evasion. (Research Article, 推荐等级 B)
  • PMID 42686911 — Robust inference and correlates from genetic associations with personality. (Meta-Analysis, 推荐等级 B)
  • PMID 42686909 — Intracellular complement factor H protects neurons during CNS inflammation. (Research Article, 推荐等级 B)
  • PMID 42686898 — Somatic mutations reveal the ontogeny of microglia in human ageing. (Research Article, 推荐等级 B)
  • PMID 42618797 — Wake-activated neuronal populations that regulate sleep drive. (Research Article, 推荐等级 B)
  • PMID 42618792 — Family genetic designs in MoBa provide insights into health and functioning. (Research Article, 推荐等级 B)
  • PMID 42618784 — Functional role of skull lymphoid structures in CNS immunosurveillance. (Research Article, 推荐等级 B)
  • PMID 42618781 — An Icelandic pangenome reference. (Research Article, 推荐等级 B)
  • PMID 42587158 — Maternal influences on infant gut microbiome and health. (Research Article, 推荐等级 B)
  • PMID 42587153 — Temporal uncoupling of radial glia lineage progression in cortical organoids. (Research Article, 推荐等级 B)
  • PMID 42557321 — A cholinergic hub in the nucleus accumbens gates opioid-reward learning. (Research Article, 推荐等级 B)
  • PMID 42557318 — Membranolytic peptide programs immunogenic cell death for cancer therapy. (Research Article, 推荐等级 B)
  • PMID 42907515 — Drought and disease trigger novel interactions among top predators. (Research Article, 推荐等级 C)
  • PMID 42778602 — The anthropogenic fingerprint on emerging infectious diseases. (Research Article, 推荐等级 C)

Science

本月无纳入文献。

Cell

  • PMID 42956738 — Innate sensor responses set a supra-unitary threshold for viral replication. (Research Article, 推荐等级 A)
  • PMID 42950818 — Multimodal spatial transcriptomics redefines cortical pathology in Huntington's disease. (Research Article, 推荐等级 A)
  • PMID 42914978 — Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity. (Research Article, 推荐等级 A)
  • PMID 42914976 — Cell-state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer. (Research Article, 推荐等级 A)
  • PMID 42906542 — In vivo Gene Writing with engineered retrotransposons. (Research Article, 推荐等级 A)
  • PMID 42906540 — A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression. (Research Article, 推荐等级 A)
  • PMID 42906538 — Proteomic atlas of T cell exhaustion defines proteostatic collapse. (Research Article, 推荐等级 A)
  • PMID 42896552 — A microbiome-bile acid axis mediates protection from chronic liver disease in females. (Research Article, 推荐等级 A)
  • PMID 42880285 — Mitochondria-targeted tetraoxanes initiate lipid peroxidation to drive ferroptosis and tumor suppression. (Research Article, 推荐等级 A)
  • PMID 42880284 — Multi-omics atlas of chronic exercise. (Research Article, 推荐等级 A)
  • PMID 42880283 — An opioid efficacy switch for reversible optical control of analgesia. (Research Article, 推荐等级 A)
  • PMID 42880282 — Functional diversification of the cephalopod proteome by RNA editing. (Research Article, 推荐等级 A)
  • PMID 42880234 — Spatiotemporal co-transcriptomics uncovers coordinated rhizobia-legume stress programs supporting nitrogen fixation in Medicago. (Research Article, 推荐等级 A)
  • PMID 42880232 — Somatic epimutations cap genetic determinism in the human diploid chromatin epigenome. (Research Article, 推荐等级 A)
  • PMID 42880231 — Comprehensive benchmarking of somatic mutation detection by the SMaHT Network. (Research Article, 推荐等级 A)
  • PMID 42880229 — Cellular scaling laws in the mammalian brain. (Review, 推荐等级 A)
  • PMID 42869022 — PTPRS mediates invasion of tetanus neurotoxin into the central nervous system. (Research Article, 推荐等级 A)
  • PMID 42849439 — Immunoregulatory gene GIMAP6 suppresses lethal atherosclerotic vasculopathy and ischemic heart failure. (Research Article, 推荐等级 A)
  • PMID 42849438 — A fluctuation test for gastruloid heterogeneity. (Research Article, 推荐等级 A)
  • PMID 42838048 — A spatiotemporal lifecycle atlas decodes spatial coordination in rice. (Research Article, 推荐等级 A)
  • PMID 42838047 — SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening. (Research Article, 推荐等级 A)
  • PMID 42822426 — Comparative analysis of mitochondrial proteomes across the tree of life. (Research Article, 推荐等级 A)
  • PMID 42822425 — A high-confidence plant mitochondrial proteome via protein correlation profiling. (Research Article, 推荐等级 A)
  • PMID 42822424 — Mitochondrial proteome of Acanthamoeba delineates aerobic and anaerobic pathways dynamically regulated by oxygen. (Research Article, 推荐等级 A)
  • PMID 42822423 — Decoding mitochondrial proteomes of diverse eukaryotes. (Research Article, 推荐等级 A)
  • PMID 42785301 — Resident tissue macrophages transfer selenium transporter protein to protect pancreatic cancer from ferroptosis. (Research Article, 推荐等级 A)
  • PMID 42772279 — A geothermal amoeba sets a new upper temperature limit for eukaryotes. (Research Article, 推荐等级 A)
  • PMID 42753735 — Toward autonomous science with agentic artificial intelligence. (Review, 推荐等级 A)
  • PMID 42716011 — Caloric restriction modulates genome-wide somatic mutation in mice. (Research Article, 推荐等级 A)
  • PMID 42679818 — De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles. (Research Article, 推荐等级 A)
  • PMID 42673964 — Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to promote goal-directed action. (Research Article, 推荐等级 A)
  • PMID 42617594 — RNA structures regulate norovirus life cycle and enable rational attenuation in vivo. (Research Article, 推荐等级 A)
  • PMID 42580337 — Convergent evolution of metabolic regulation governs redox adaptation in Toxoplasma. (Research Article, 推荐等级 A)
  • PMID 42575089 — The structural basis for LRRK2's activation and autoinhibition. (Research Article, 推荐等级 A)
  • PMID 42551423 — Metabolic atlas of early human cortex reveals glycolytic remodeling and pentose phosphate pathway control of cell fate transitions. (Research Article, 推荐等级 A)
  • PMID 42546689 — Ultrarapid deep 3D histology enables intraoperative mapping of glioma infiltration. (Research Article, 推荐等级 A)
  • PMID 42526438 — CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer. (Research Article, 推荐等级 A)
  • PMID 42962658 — Age-dependent structural evolution of a functional amyloid contributes to memory impairment in Drosophila. (Research Article, 推荐等级 B)
  • PMID 42956714 — Roads not taken: The mismatch between safety and regulation of plant breeding innovation. (Research Article, 推荐等级 B)
  • PMID 42950817 — Somatic DNA-repeat expansions initiate distinct yet analogous changes in Huntington's disease cortical and striatal neurons. (Research Article, 推荐等级 B)
  • PMID 42945956 — Deep sequencing of 3,367 maize genomes uncovers substantial contribution of rare variants to agronomic traits. (Research Article, 推荐等级 B)
  • PMID 42933389 — In vivo genome-editing therapy for Duchenne muscular dystrophy: Preclinical studies and first-in-human trial. (Research Article, 推荐等级 B)
  • PMID 42913630 — Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade. (Research Article, 推荐等级 B)
  • PMID 42896553 — The pyrin inflammasome senses OCTN2-mediated uptake of extracellular ʟ-carnitine from muscle injury or ingestion. (Research Article, 推荐等级 B)
  • PMID 42880286 — A phenome-wide structural variant map from 467,152 UK Biobank genomes. (Research Article, 推荐等级 B)
  • PMID 42880281 — Cellular self-organization orchestrates ferroptosis propagation. (Research Article, 推荐等级 B)
  • PMID 42880233 — A telomere-to-telomere map of somatic mutation burden and functional impact in a cancer. (Research Article, 推荐等级 B)
  • PMID 42880230 — Charting the silent variation within us. (Research Article, 推荐等级 B)
  • PMID 42874590 — A pseudoenzyme sensor of trehalose-6-phosphate directly represses the metabolic integrator SnRK1 in plants. (Research Article, 推荐等级 B)
  • PMID 42869023 — A high-dimensional population code in the bat motor cortex during natural dexterous flight. (Research Article, 推荐等级 B)
  • PMID 42869021 — Mechanisms of transcription control by distal enhancers from single-gene nanoscopy. (Research Article, 推荐等级 B)
  • PMID 42869020 — Rare k-mers reveal centromere haplogroups underlying human diversity and cancer translocations. (Research Article, 推荐等级 B)
  • PMID 42854686 — Mapping transcriptional responses to cellular perturbations with RNA fingerprinting. (Research Article, 推荐等级 B)
  • PMID 42849436 — Comprehensive lineage tracing maps the landscape of cell fate decisions in mouse embryogenesis. (Research Article, 推荐等级 B)
  • PMID 42838049 — A non-canonical function of glutathione to suppress ferroptosis via FSP1. (Research Article, 推荐等级 B)
  • PMID 42838046 — Cancer competition for vitamin B2 creates metabolic checkpoint for T cell ferroptosis. (Research Article, 推荐等级 B)
  • PMID 42838045 — STING reprogramming by estrogen promotes neutrophil extracellular trap formation and sex-biased resistance to ADC therapy. (Research Article, 推荐等级 B)
  • PMID 42822427 — Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS. (Research Article, 推荐等级 B)
  • PMID 42805174 — Opposing functions of gut immunomodulatory metabolites on CAR-T therapy. (Research Article, 推荐等级 B)
  • PMID 42772280 — Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation. (Research Article, 推荐等级 B)
  • PMID 42759515 — Oligodendrocytes in central nervous system health and disease. (Review, 推荐等级 B)
  • PMID 42735689 — Copper ion-induced MYH9 polymerization executes cuproptosis. (Research Article, 推荐等级 B)
  • PMID 42727576 — Glycocalyx-edited mesenchymal stem/stromal cell therapy in advanced osteoporosis. (Clinical Trial, 推荐等级 B)
  • PMID 42727575 — Metax enables accurate cross-domain taxonomic profiling of metagenomes. (Research Article, 推荐等级 B)
  • PMID 42705230 — Identification of the tendon/ligament stem cell in mice and humans. (Research Article, 推荐等级 B)
  • PMID 42685689 — Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types. (Research Article, 推荐等级 B)
  • PMID 42679822 — Live-cell transcriptomics with engineered virus-like particles. (Research Article, 推荐等级 B)
  • PMID 42679820 — Ratiometric transcriptional activation by protein degradation. (Research Article, 推荐等级 B)
  • PMID 42679819 — Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities. (Research Article, 推荐等级 B)
  • PMID 42664972 — Genome-scale perturb-seq in primary human CD4 + T cells maps context-specific regulators of T cell programs and human immune traits. (Research Article, 推荐等级 B)
  • PMID 42664971 — Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling. (Research Article, 推荐等级 B)
  • PMID 42641604 — Integrative spatial profiling of 3D genome organization and gene expression in tissue. (Research Article, 推荐等级 B)
  • PMID 42636811 — DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development. (Research Article, 推荐等级 B)
  • PMID 42617596 — Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits. (Research Article, 推荐等级 B)
  • PMID 42612631 — Multimodal brain cell atlas across the adult macaque lifespan. (Research Article, 推荐等级 B)
  • PMID 42600613 — Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human. (Research Article, 推荐等级 B)
  • PMID 42594865 — Functional atlas of vertebrate viral RNA elements that stabilize RNA and enhance translation. (Research Article, 推荐等级 B)
  • PMID 42546688 — Co-option of retrotransposons promotes antibody diversification. (Research Article, 推荐等级 B)
  • PMID 42546687 — Milk osteopontin alters the infant microbiome to drive DC hematopoiesis and disease tolerance. (Research Article, 推荐等级 B)
  • PMID 42526439 — Gasdermin E couples viral pyroptosis to lethal hepatic lipid accumulation. (Research Article, 推荐等级 B)
  • PMID 42492508 — An Oryza orphan gene confers trans-species drought tolerance. (Research Article, 推荐等级 B)
  • PMID 42492507 — Trichoderma swollenin activates AtABCB5-dependent auxin efflux to promote plant development. (Research Article, 推荐等级 B)
  • PMID 42486083 — Condensates of the chromatin regulator ANKRD11 restrict hypertranscribed genes to safeguard development. (Research Article, 推荐等级 B)
  • PMID 42468524 — Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context. (Research Article, 推荐等级 B)
  • PMID 42956717 — Toward planetary microbial systems biology. (Review, 推荐等级 C)
  • PMID 42612632 — Mutually beneficial interactions between bacteria and Arabidopsis promote phosphorus nutrition and growth. (Research Article, 推荐等级 C)

三、逐篇文献解读

以下精选 20 篇 A 级高优先级文献进行详细解读。其余纳入文献的核心信息已列于上文总表。

文献 1

英文题目： Connectome simulations identify a central pattern generator for fly walking.

中文题目： 连接组模拟鉴定出果蝇行走的中央模式发生器

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Pugliese Sarah M, Chou Grant M, Abe Elliott T T, Turcu Denis, Lancaster Jackson K et al. DOI： 10.1038/s41586-026-11195-y PMID： 42951971官方链接： https://www.nature.com/articles/s41586-026-11195-y PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42951971/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 细胞生物学, 遗传学与基因组学, 药物研发, 人工智能 推荐等级： A

1. 原文摘要

Animal locomotion relies on rhythmic body movements driven by central pattern generators (CPGs): neural circuits that produce oscillating output without oscillating input. However, the circuit structure of a CPG for walking is not known in any animal1,2. To identify the cells and synapses that underlie rhythmic leg movement in walking flies, we developed dynamic simulations of the Drosophila ventral nerve cord connectomes3-6. A computational activation screen of descending neurons from the central brain identified DNg100-a known command neuron for walking-as the strongest driver of rhythmic leg motor activity. Simulated network pruning isolated a minimal rhythm-generating circuit consisting of one inhibitory and two excitatory interneurons; this three-neuron circuit was necessary and sufficient for motor rhythms across all six legs and in four connectome datasets. Simulations also predicted that a separate descending pathway (DNb08) drives rhythmic leg movements, which we confirmed experimentally using optogenetics in behaving flies. Our results reveal the cellular identity and synaptic structure of a putative CPG circuit for walking and other rhythmic leg movements in flies.

2. 摘要中文翻译

动物运动依赖于由中央模式发生器（CPG）驱动的节律性躯体运动：CPG 是一类无需振荡输入即可产生振荡输出的神经回路。然而，迄今在任何动物中，行走 CPG 的回路结构都尚不清楚。为了鉴定果蝇腿部节律运动背后的细胞与突触，我们开发了果蝇腹神经索连接组的动力学模拟。对来自中央脑的下行神经元进行计算激活筛选，发现 DNg100——一个已知的步行指令神经元——是节律性腿部运动活动的最强驱动者。模拟网络剪枝分离出一个最小的节律产生回路，由一个抑制性中间神经元和两个兴奋性中间神经元组成；这一三神经元回路在全部六条腿以及四个连接组数据集中对运动节律既必要又充分。模拟还预测了另一条下行通路（DNb08）可驱动节律性腿部运动，我们随后在行为果蝇中通过光遗传学实验予以证实。我们的结果揭示了果蝇行走及其他节律性腿部运动的候选 CPG 回路的细胞身份和突触结构。

3. 摘要层面解读

  • 研究对象： 果蝇腹神经索连接组、中央模式发生器（CPG）、DNg100/DNb08 下行神经元、腿部运动节律
  • 核心科学问题： 行走 CPG 的细胞组成与突触连接结构是什么？能否仅凭连接组数据预测并验证节律回路？
  • 主要方法： 果蝇腹神经索连接组动力学模拟；下行神经元计算激活筛选；模拟网络剪枝；光遗传学行为学验证。
  • 主要发现： 鉴定出由 1 个抑制性和 2 个兴奋性中间神经元组成的最小三神经元节律回路，在六条腿和四个连接组数据集中均必要且充分；预测并实验验证了 DNb08 为第二条节律驱动通路。
  • 方向归属： 神经科学, 细胞生物学, 遗传学与基因组学, 药物研发, 人工智能
  • 值得关注的原因： 首次在任何动物中给出行走 CPG 的细胞身份与突触结构，展示了连接组模拟-实验闭环的研究范式。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

以计算模拟直接从连接组中解析出最小行走节律回路并用光遗传学验证，是神经回路结构与功能研究的标杆性工作。

文献 2

英文题目： Genetic variants shape single-cell chromatin accessibility and disease risk.

中文题目： 遗传变异塑造单细胞染色质可及性与疾病风险

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Xue Angli, Fan Jianan, Dong Oscar A, Huang Hao Lawrence, Chen Ling et al. DOI： 10.1038/s41586-026-11173-4 PMID： 42951970官方链接： https://www.nature.com/articles/s41586-026-11173-4 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42951970/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 免疫学, 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学, 生物技术 推荐等级： A

1. 原文摘要

Understanding how genetic variation shapes gene regulation at single-cell resolution is crucial for elucidating complex disease mechanisms1, but has been limited by the lack of large-scale single-cell multi-omics data2-4. Here we present single-cell assay for transposase-accessible chromatin with sequencing of 3.5 million peripheral blood mononuclear cells from 1,042 donors with matched whole-genome sequencing. Across 28 immune cell types, we tested 440,996 chromatin accessibility peaks and identified 243,225 chromatin accessibility quantitative trait loci (caQTLs) at 100,483 peaks, 60% of them cell-type specific. Rare variant analysis identified 38,161 associated peaks, with predicted transcription factor-binding disruption implicated at individual loci. Colocalization with expression QTLs (eQTLs) from single-cell RNA sequencing data (5.4 million peripheral blood mononuclear cells)5 defined 28,834 candidate cis-regulatory elements. Across genome-wide association studies for 16 diseases and 44 blood traits, caQTLs colocalized 4.5-22.6% more signals than eQTLs alone. Cell-type-specific and tissue-specific context, distal effects and multi-causal-variant models raised genome-wide association study-eQTL concordance from approximately 16% to approximately 65%. Cell state further modulates genetic effects, with 27% of over 200,000 caQTL-cell-state interactions lacking a main effect. At the inflammatory bowel disease risk gene ADCY7, accessibility effects varied with genotype and G protein-mediated pathway activity in CD4+ T cells. A graph neural network trained on both eQTL and caQTL layers inferred peak-gene links in unpaired multiome data with up to 17.2% higher accuracy than QTL-agnostic data, uncovering 128 additional transcription factor-target pairs (22% increase). Together, these results show that genetic variants shape chromatin accessibility in a cell-type-specific and cell-state-specific manner, influencing immune function and disease risk.

2. 摘要中文翻译

在单细胞分辨率下理解遗传变异如何塑造基因调控，对阐明复杂疾病机制至关重要，但此前受限于大规模单细胞多组学数据的缺乏。本研究对来自 1,042 名供者（匹配全基因组测序）的 350 万个外周血单个核细胞进行了单细胞 ATAC 测序。在 28 种免疫细胞类型中，我们检验了 440,996 个染色质可及性峰，鉴定出 243,225 个染色质可及性数量性状位点（caQTLs），涉及 100,483 个峰，其中 60% 具有细胞类型特异性。罕见变异分析鉴定出 38,161 个关联峰，并在个别位点上提示转录因子结合被破坏。与单细胞 RNA 测序 eQTL 数据（540 万个外周血单个核细胞）共定位，定义了 28,834 个候选顺式调控元件。在 16 种疾病和 44 项血液性状的全基因组关联研究（GWAS）中，caQTLs 比 eQTLs 单独使用多共定位 4.5-22.6% 的信号。细胞类型与组织特异性背景、远端效应和多因果变异模型将 GWAS-eQTL 一致性从约 16% 提升至约 65%。细胞状态进一步调节遗传效应：超过 20 万个 caQTL-细胞状态互作中，27% 缺乏主效应。在炎症性肠病风险基因 ADCY7 上，可及性效应随基因型和 CD4+ T 细胞中 G 蛋白介导的通路活性而变化。基于 eQTL 与 caQTL 双层训练的图神经网络在非配对多组学数据中推断峰-基因关联的准确率最高提升 17.2%，并额外发现 128 对转录因子-靶基因（增加 22%）。这些结果表明，遗传变异以细胞类型和细胞状态特异的方式塑造染色质可及性，影响免疫功能与疾病风险。

3. 摘要层面解读

  • 研究对象： 外周血单个核细胞、单细胞 ATAC-seq、caQTL、免疫细胞类型、复杂疾病 GWAS
  • 核心科学问题： 遗传变异如何在单细胞和细胞状态水平塑造染色质可及性，并由此解释复杂疾病的遗传风险？
  • 主要方法： 1,042 名供者 350 万细胞的单细胞 ATAC 测序；caQTL 与罕见变异关联分析；与单细胞 eQTL 共定位；图神经网络推断峰-基因调控关系。
  • 主要发现： 构建了迄今最大规模的免疫细胞 caQTL 图谱；caQTL 显著提升 GWAS 信号解释力；细胞状态使 27% 的 caQTL 效应消失；图神经网络将峰-基因推断准确率提升 17.2%。
  • 方向归属： 神经科学, 免疫学, 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学, 生物技术
  • 值得关注的原因： 为复杂疾病风险变异的功能注释提供了细胞类型特异的染色质调控维度，是单细胞遗传学资源的里程碑。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

超大规模单细胞 caQTL 图谱将疾病遗传学推向细胞状态分辨率，是基因组学与免疫学交叉的重要资源型突破。

文献 3

英文题目： Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers.

中文题目： METTL1 的药理学抑制作为实体瘤与血液肿瘤的治疗策略

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Yankova Eliza, Sapetschnig Alexandra, Thomas Beth, Evans Siân, Eleftheriou Maria et al. DOI： 10.1038/s41586-026-11178-z PMID： 42951963官方链接： https://www.nature.com/articles/s41586-026-11178-z PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42951963/ OA 状态： 非 OA / 需订阅访问研究领域： 肿瘤学, 发育生物学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

The N7-methylguanosine (m7G) modification is one of the most prevalent tRNA modifications, mainly catalysed by the METTL1-WDR4 protein complex1-4. The m7G methyltransferase METTL1 has been linked to oncogenic transformation and the maintenance of several aggressive malignancies; however, the clinical implications of therapeutically targeting a tRNA-modifying enzyme have not been established. Here we present the development and characterization of STM9005, a highly selective and potent first-in-class tRNA methyltransferase inhibitor of METTL1. Treatment of numerous cancer cell models (including leukaemia, melanoma, pancreatic carcinoma, oesophageal cancer and small cell lung carcinoma) with STM9005 blocks cell growth, causes differentiation changes and dysregulates cell cycle progression. These cellular effects were accompanied by a selective decrease in m7G on a subset of tRNAs and a reduction in their expression levels, which impacted the translation of oncogenic mRNAs. We show that pharmacological inhibition of METTL1 in vivo impairs tumour growth and significantly prolongs survival in multiple mouse cancer models of different tissue origin. Collectively, our results provide a strong proof of concept that targeting of tRNA methylation is a promising avenue of anti-cancer therapy and illustrate that catalytic inhibition of METTL1 represents a therapeutic strategy against a number of aggressive malignancies.

2. 摘要中文翻译

N7-甲基鸟苷（m7G）修饰是最普遍的 tRNA 修饰之一，主要由 METTL1-WDR4 蛋白复合物催化。m7G 甲基转移酶 METTL1 与致癌转化及多种侵袭性恶性肿瘤的维持相关；然而，靶向 tRNA 修饰酶的治疗学意义尚未确立。本研究报道了 STM9005 的开发与表征——一种高选择性、高效的同类首创（first-in-class）METTL1 tRNA 甲基转移酶抑制剂。在多种癌症细胞模型（包括白血病、黑色素瘤、胰腺癌、食管癌和小细胞肺癌）中，STM9005 阻断细胞生长、引起分化改变并扰乱细胞周期进程。这些细胞效应伴随一小部分 tRNA 上 m7G 的选择性下降及其表达水平降低，进而影响致癌 mRNA 的翻译。我们还证明，在体内对 METTL1 进行药理学抑制可损害肿瘤生长，并在多种不同组织来源的小鼠癌症模型中显著延长生存期。总之，我们的结果提供了强有力的概念验证，表明靶向 tRNA 甲基化是一条有前景的抗癌治疗途径，并说明 METTL1 的催化抑制可作为针对多种侵袭性恶性肿瘤的治疗策略。

3. 摘要层面解读

  • 研究对象： METTL1-WDR4 复合物、tRNA m7G 修饰、小分子抑制剂 STM9005、多类癌症模型
  • 核心科学问题： 抑制 tRNA 甲基转移酶 METTL1 能否成为跨组织来源恶性肿瘤的有效治疗策略？
  • 主要方法： 同类首创小分子抑制剂 STM9005 的开发与选择性表征；多种癌细胞系与小鼠肿瘤模型药效评估；tRNA m7G 修饰与翻译组分析。
  • 主要发现： STM9005 选择性降低特定 tRNA 的 m7G 修饰，下调致癌 mRNA 翻译，在多种小鼠肿瘤模型中抑制肿瘤生长并延长生存期。
  • 方向归属： 肿瘤学, 发育生物学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学
  • 值得关注的原因： 首次证明药理学靶向 tRNA 修饰酶可行且有效，将 RNA 修饰生物学转化为可成药的抗癌治疗方向。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

同类首创 METTL1 抑制剂的确立开辟了"靶向 tRNA 甲基化治癌"的全新领域，对 RNA 修饰药物研发具有开创意义。

文献 4

英文题目： Programmable design of functional proteins from natural language.

中文题目： 从自然语言可编程设计功能蛋白质

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Dai Fengyuan, You Shiyang, Zhu Yudian, Gao Yuan, Fu Lihao et al. DOI： 10.1038/s41586-026-11205-z PMID： 42907516官方链接： https://www.nature.com/articles/s41586-026-11205-z PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42907516/ OA 状态： 非 OA / 需订阅访问研究领域： 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学 推荐等级： A

1. 原文摘要

Programming biological function-designing bespoke proteins to perform specified molecular tasks-is a foundational goal of molecular engineering. However, current design models remain fundamentally limited1-3: they typically require either natural proteins as starting points for optimization or manual reformulation of functional goals as geometric and sequence-level constraints to guide candidate generation. Here we introduce Pinal, a 16-billion-parameter foundation model that designs candidate proteins from natural-language descriptions of desired function. Trained on 1.7 billion synthetically annotated protein-text pairs, Pinal links functional intent to protein sequence and structure. In computational evaluations, generated candidates combined high predicted foldability with functional-description alignment and sequence diversity, providing a basis for prioritizing experimentally testable designs. We applied Pinal to four distinct design tasks-a fluorescent protein, a polyethylene terephthalate hydrolase, an alcohol dehydrogenase and a metabolic H-protein-and experimentally observed the intended function in each case, including catalytic activity for both designed enzymes. Without iterative experimental optimization, a Pinal-designed H-protein increased product titre by 1.7-fold relative to the corresponding native Escherichia coli H-protein in a multi-enzyme CO2 fixation pathway. These findings support natural language as a high-level interface for candidate generation in protein design, enabling programmable exploration with reduced reliance on manually specified structural or sequence constraints.

2. 摘要中文翻译

对生物功能进行编程——设计执行特定分子任务的定制蛋白质——是分子工程的基础目标。然而，当前设计模型存在根本局限：它们通常要么需要以天然蛋白质为优化起点，要么需要将功能目标人工转译为几何与序列层面的约束来指导候选生成。本研究介绍 Pinal——一个 160 亿参数的基础模型，可从期望功能的自然语言描述出发设计候选蛋白质。Pinal 基于 17 亿个合成标注的蛋白质-文本对训练，将功能意图与蛋白质序列和结构关联起来。在计算评估中，生成的候选兼具高预测可折叠性、与功能描述的对齐性和序列多样性，为优先选择可实验检验的设计提供了依据。我们将 Pinal 应用于四项不同设计任务——荧光蛋白、聚对苯二甲酸乙二醇酯水解酶、醇脱氢酶和代谢 H 蛋白——并在每种情况下均实验观察到预期功能，包括两种设计酶的催化活性。在无需迭代实验优化的情况下，Pinal 设计的 H 蛋白在多酶 CO2 固定通路中将产物滴度相对于相应的天然大肠杆菌 H 蛋白提高了 1.7 倍。这些发现支持自然语言作为蛋白质设计候选生成的高级接口，实现对可编程探索的加速，并减少对人工指定结构或序列约束的依赖。

3. 摘要层面解读

  • 研究对象： 蛋白质设计基础模型 Pinal、自然语言功能描述、酶与功能蛋白的从头设计
  • 核心科学问题： 能否以自然语言为唯一接口，直接从功能描述生成可实验验证的功能蛋白？
  • 主要方法： 160 亿参数蛋白质-文本基础模型；17 亿合成标注蛋白质-文本对训练；四种设计任务的计算筛选与实验验证。
  • 主要发现： 四种设计任务全部在实验中观察到预期功能；无需迭代优化，设计的 H 蛋白使 CO2 固定通路产物滴度提高 1.7 倍。
  • 方向归属： 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学
  • 值得关注的原因： 将自然语言确立为蛋白质设计的高级编程接口，显著降低了功能蛋白设计的门槛，代表 AI for biology 的前沿方向。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

Pinal 首次实现"用一句话设计出有功能的蛋白质"，是生成式 AI 蛋白质设计范式的标志性进展。

文献 5

英文题目： GRP75-dependent SIMPA mediates inter-organellar quality control.

中文题目： GRP75 依赖的 SIMPA 介导细胞器间质量控制

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Yu Fan, Jiang Lingyu, Liu Hanyu, Yang Song, Yuan Yuan et al. DOI： 10.1038/s41586-026-10733-y PMID： 42907503官方链接： https://www.nature.com/articles/s41586-026-10733-y PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42907503/ OA 状态： 非 OA / 需订阅访问研究领域： 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

Mitochondria are bound by a double membrane and are semiautonomous organelles, rendering them highly vulnerable to global and internal proteostatic stress1. Multiple surveillance mechanisms at proteostatic and inter-organellar levels have evolved to maintain mitochondrial integrity and cellular health2-7. However, the precise mechanisms by which proteostatic damage relays stress signals across organelles and how the quality surveillance machinery coordinates these functions remain unknown. Here we report that under proteostatic stress, damaged mitochondrial proteins are sequestered to form stress-induced mitochondrial protein aggregates (SIMPAs) that activate specific quality control mechanisms in a spatially confined manner without perturbing the mitochondrial network. Quantitative proteomic and correlative light-electron microscopy analysis revealed that SIMPA mediates inter-organellar communication via mitochondria-endoplasmic reticulum contact sites or mitochondrial-associated membranes. Mechanistically, GRP75 coordinates SIMPA biogenesis and focally activates endoplasmic reticulum unfolded protein response pathways via mitochondria-endoplasmic reticulum contact sites or mitochondrial-associated membranes for the targeted clearance of SIMPAs. Functionally, in both cellular and liver disease models, we found that a GRP75-dependent SIMPA signalling cascade attenuates mitochondrial stress and preserves mitochondrial integrity under proteotoxic stress. Overall, we show that SIMPAs, functioning as protein condensates, serve as a central cross-compartment communication hub for mitochondrial quality control, supporting cellular and organismal fitness.

2. 摘要中文翻译

线粒体由双层膜包被且呈半自主性，因而对全局和内部蛋白稳态应激高度易感。在蛋白稳态和细胞器间水平上，已演化出多种监视机制以维持线粒体完整性和细胞健康。然而，蛋白稳态损伤如何在细胞器间传递应激信号，以及质量监视机制如何协调这些功能，仍属未知。本研究报道，在蛋白稳态应激下，受损的线粒体蛋白被隔离形成应激诱导线粒体蛋白聚集体（SIMPAs），以一种空间受限的方式激活特异性质量控制机制，而不扰动线粒体网络。定量蛋白质组学和关联光电显微分析显示，SIMPA 通过线粒体-内质网接触位点（即线粒体相关膜）介导细胞器间通讯。机制上，GRP75 协调 SIMPA 的生物发生，并经由线粒体-内质网接触位点局灶性激活内质网未折叠蛋白反应通路，以实现 SIMPAs 的定向清除。功能上，在细胞和肝脏疾病模型中，我们发现 GRP75 依赖的 SIMPA 信号级联在蛋白毒性应激下减轻线粒体应激并维护线粒体完整性。总体而言，我们证明 SIMPAs 作为蛋白质凝聚体，充当线粒体质量控制的跨区室通讯中枢，支持细胞与机体的健康。

3. 摘要层面解读

  • 研究对象： 线粒体蛋白应激聚集体（SIMPA）、GRP75、线粒体-内质网接触位点、细胞器间质量控制
  • 核心科学问题： 线粒体蛋白稳态损伤如何跨细胞器传递信号并被定向清除？
  • 主要方法： 定量蛋白质组学；关联光-电子显微镜（CLEM）；线粒体-内质网接触位点成像；细胞与肝脏疾病模型功能验证。
  • 主要发现： 发现 SIMPA 应激聚集体作为蛋白凝聚体枢纽，经 GRP75 在线粒体-内质网接触位点局灶激活内质网未折叠蛋白反应，实现损伤蛋白的定向清除。
  • 方向归属： 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学
  • 值得关注的原因： 揭示了细胞器间质量控制的新解剖学位点与分子机制，将线粒体应激与内质网应激响应整合为统一框架。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

SIMPA-GRP75 轴的发现为细胞器间通讯和蛋白稳态调控提供了全新的机制模型，对肝病等蛋白毒性相关疾病有转化启示。

文献 6

英文题目： A microexon regulatory code reveals autism-linked genetic variation.

中文题目： 微外显子调控密码揭示自闭症相关遗传变异

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Parada Guillermo E, Bretschneider Hannes, Li Jack Daiyang, Fine Jacob L, Dupas Steven J et al. DOI： 10.1038/s41586-026-11119-w PMID： 42875502官方链接： https://www.nature.com/articles/s41586-026-11119-w PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42875502/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 遗传学与基因组学, 人工智能 推荐等级： A

1. 原文摘要

Neuronal microexons are a highly conserved class of alternative splicing events enriched in genes with critical functions in nervous system biology1,2. Microexon splicing is often disrupted in the brains of autistic individuals, and mice with microexon deficiencies display autism-like phenotypes1,3,4. However, the full landscape of microexons is not known, and the impact of genetic variation on these exons has not been systematically investigated. Here, through extensive transcriptome profiling, we detect hundreds of new microexons, including many with neuronal subtype-specific splicing patterns, and others that activate nonsense-mediated mRNA decay. Using machine learning, we define a sequence code predictive of neuronally spliced microexons and use this to identify critical regulatory elements surrounding the expanded microexon repertoire. This code further reveals genomic variants predicted to alter microexon splicing in individuals affected by autism, with rare variants having the strongest estimated impact. These variants are mostly detected in idiopathic individuals and are associated with autism status. They also converge on synaptic and other autism-linked genes, as well as genes not previously linked to autism. Our results collectively define an expanded repertoire of microexons, delineate their regulatory code, and pinpoint variants predicted to affect their splicing, with implications for the disruption of functions central to neuronal biology and brain disorders.

2. 摘要中文翻译

神经元微外显子是一类高度保守的可变剪接事件，富集于对神经系统生物学具有关键功能的基因中。微外显子剪接在自闭症患者脑中常被破坏，微外显子缺陷小鼠表现出自闭症样表型。然而，微外显子的全景图谱尚不清楚，遗传变异对这些外显子的影响也未获系统研究。本研究通过广泛的转录组分析，检测到数百个新微外显子，其中许多具有神经元亚型特异的剪接模式，另一些则激活无义介导的 mRNA 降解。利用机器学习，我们定义了可预测神经元剪接微外显子的序列密码，并借此鉴定扩展微外显子库周围的关键调控元件。该密码进一步揭示了预测可改变自闭症患者微外显子剪接的基因组变异，其中罕见变异的估计影响最强。这些变异大多在特发性患者中检出，并与自闭症状态相关；它们还汇聚于突触及其他自闭症相关基因，以及此前与自闭症无关的基因。我们的结果共同定义了扩展的微外显子库，刻画了其调控密码，并精准定位了预测可影响其剪接的变异，对神经生物学和脑疾病核心功能的破坏具有启示意义。

3. 摘要层面解读

  • 研究对象： 神经元微外显子、可变剪接调控序列密码、自闭症谱系障碍遗传变异
  • 核心科学问题： 神经元微外显子的全景与剪接调控密码是什么，自闭症相关的罕见变异如何通过微外显子剪接致病？
  • 主要方法： 大规模转录组分析扩展微外显子库；机器学习定义剪接调控序列密码；变异-剪接预测与自闭症队列关联分析。
  • 主要发现： 发现数百个新微外显子及其亚型特异剪接模式；建立预测性微外显子调控密码；鉴定出大量预测破坏微外显子剪接的自闭症相关罕见变异。
  • 方向归属： 神经科学, 遗传学与基因组学, 人工智能
  • 值得关注的原因： 将自闭症遗传学从基因层面推进到"微外显子剪接密码"层面，为特发性自闭症提供了新的致病变异解释维度。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

以机器学习解码微外显子调控密码并用于自闭症变异解读，是 RNA 剪接与神经精神疾病交叉领域的代表性突破。

文献 7

英文题目： Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism.

中文题目： 工程化 TYK2 依赖性实现髓系选择性的 IL-10 受体激动

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Canaria D Alejandro, Nguyen Trang T T, Huang Huang, Xu Hui, Yue Lili et al. DOI： 10.1038/s41586-026-11176-1 PMID： 42875499官方链接： https://www.nature.com/articles/s41586-026-11176-1 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42875499/ OA 状态： 非 OA / 需订阅访问研究领域： 免疫学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

Interleukin-10 (IL-10) is a central anti-inflammatory cytokine that suppresses immune responses in myeloid cells but can also activate T cells, limiting its therapeutic use in chronic inflammatory diseases owing to narrow efficacy windows and dose-limiting toxicities1-5. Here we show that myeloid and T cells differ in their dependence on JAK-family kinase pairing for IL-10 signalling and function. We took advantage of this differential kinase dependence to engineer a tetravalent nanobody-based myeloid-selective IL-10 receptor agonist (msIL-10R agonist) that fully recapitulates IL-10's potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells. Cryo-electron microscopy structural analysis reveals a distinct receptor cross-linking geometry of the msIL-10R agonist compared with native IL-10 family cytokines. This tetravalent architecture renders signalling strictly TYK2-dependent and highly sensitive to IL-10Rα and IL-10Rβ receptor abundance, thereby conferring selective activity in myeloid cells. This msIL-10R agonist reduces inflammation in humanized mouse models of lipopolysaccharide challenge, delayed-type hypersensitivity and colitis. A humanized version exhibits IgG-like pharmacokinetics, sustained receptor occupancy and durable myeloid suppression up to 30 days without T cell activation or haematological toxicities in non-human primates. These findings establish a geometry-based strategy for achieving cell-type-selective cytokine signalling and identify the msIL-10R agonist as a therapeutic candidate for myeloid-driven inflammatory diseases, including inflammatory bowel diseases.

2. 摘要中文翻译

白细胞介素-10（IL-10）是一种核心抗炎细胞因子，可抑制髓系细胞的免疫反应，但也会激活 T 细胞，因疗效窗口窄和剂量限制性毒性而限制其治疗应用。本研究发现髓系细胞与 T 细胞在 IL-10 信号与功能上对 JAK 家族激酶配对的依赖性不同。我们利用这种差异化的激酶依赖性，工程化构建了基于四价纳米抗体的髓系选择性 IL-10 受体激动剂（msIL-10R 激动剂），它完全重现 IL-10 对单核细胞、巨噬细胞和树突状细胞的强效抑制，同时避免激活 T 细胞。冷冻电镜结构分析揭示了 msIL-10R 激动剂区别于天然 IL-10 家族细胞因子的独特受体交联几何构型。这种四价架构使信号转导严格依赖 TYK2，并对 IL-10Rα 与 IL-10Rβ 的受体丰度高度敏感，从而赋予髓系细胞选择性活性。该 msIL-10R 激动剂在人源化小鼠的脂多糖攻击、迟发型超敏反应和结肠炎模型中减轻炎症。人源化版本在非人灵长类中表现出 IgG 样药代动力学、持续的受体占据和长达 30 天的持久髓系抑制，且无 T 细胞激活或血液学毒性。这些发现确立了基于几何构型实现细胞类型选择性细胞因子信号的设计策略，并将 msIL-10R 激动剂确立为髓系驱动炎症性疾病（包括炎症性肠病）的治疗候选药物。

3. 摘要层面解读

  • 研究对象： IL-10 信号通路、四价纳米抗体 agonist、TYK2 激酶依赖性、髓系细胞选择性抗炎
  • 核心科学问题： 如何规避 IL-10 的 T 细胞激活毒性，实现仅作用于髓系细胞的选择性抗炎治疗？
  • 主要方法： 差异激酶依赖性分析；四价纳米抗体 agonist 工程设计；冷冻电镜结构解析；人源化小鼠炎症模型与非人灵长类药理学评估。
  • 主要发现： 四价受体交联几何使 IL-10 信号严格依赖 TYK2，实现髓系选择；非人灵长类中持久抑制髓系且无 T 细胞激活与血液学毒性。
  • 方向归属： 免疫学, 药物研发, 蛋白质科学
  • 值得关注的原因： 提出"以受体交联几何编码细胞选择性"的细胞因子药物设计新范式，为炎症性肠病等髓系驱动疾病提供高选择性治疗候选。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

以几何工程破解 IL-10 疗法毒性难题，是细胞因子药物工程化的典范性工作。

文献 8

英文题目： Elp1 is required for myeloid differentiation and brain repopulation.

中文题目： Elp1 是髓系分化与脑微胶质细胞重建所必需

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Mader Marius Marc-Daniel, Li Wanhua, Scavetti Alexa, Yoo Yongjin, Neumayer Gernot et al. DOI： 10.1038/s41586-026-11112-3 PMID： 42875495官方链接： https://www.nature.com/articles/s41586-026-11112-3 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42875495/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 发育生物学, 细胞生物学, 遗传学与基因组学, 蛋白质科学 推荐等级： A

1. 原文摘要

Haematopoietic stem and progenitor cell (HSPC) transplantation-mediated replacement of microglia-the reconstitution of the central nervous system microglial niche with donor-derived myeloid cells-represents a promising strategy for brain cell therapies1-7. However, the cell-intrinsic molecular regulators of HSPC-derived myeloid lineage commitment in the brain have remained largely uncharacterized. This is partially because the scarcity of primary HSPCs has rendered large-scale genetic interrogation intractable. Here we explored whether ex vivo expansion of primary cultured HSPCs (cHSPCs) enables unbiased genetic interrogation of haematopoietic differentiation. We established that cHSPCs can be genetically manipulated and readily differentiate into myeloid cells and repopulate microglia niches of the brain after transplantation. Moreover, primary neonatal astrocytes contained strong signals to induce myeloid specification of cHSPCs in vitro. To identify genes that regulate glia-induced myeloid differentiation, we successfully screened around 20,000 individual genetic perturbations and characterized genes involved in the regulation of cell signalling, cell cycle, mitochondrial function and protein translation. Among these genes was elongator acetyltransferase complex subunit 1 (Elp1), which suppressed the unfolded protein response during myeloid specification and was essential for the generation but not maintenance of myeloid cells. Our work establishes a platform to investigate the molecular mechanisms of brain myeloid biology.

2. 摘要中文翻译

造血干细胞和祖细胞（HSPC）移植介导的小胶质细胞替代——即用供者来源髓系细胞重建中枢神经系统微胶质细胞生态位——是一种有前景的脑细胞治疗策略。然而，HSPC 来源髓系谱系在脑内定向的细胞内在分子调控因子在很大程度上未被表征。这一部分是因为原代 HSPC 的稀缺使大规模遗传筛查难以实施。本研究探索了原代培养 HSPCs（cHSPCs）的体外扩增是否能实现造血分化的无偏遗传研究。我们确立 cHSPCs 可被遗传操作，并在移植后 readily 分化为髓系细胞并重建脑内微胶质细胞生态位。此外，原代新生星形胶质细胞在体外含有诱导 cHSPCs 髓系定向的强信号。为鉴定调控胶质细胞诱导髓系分化的基因，我们成功筛选了约 20,000 个独立遗传扰动，并表征了涉及细胞信号、细胞周期、线粒体功能和蛋白质翻译调控的基因。其中包括延伸体乙酰转移酶复合物亚基 1（Elp1），它在髓系定向过程中抑制未折叠蛋白反应，并且是髓系细胞的产生（而非维持）所必需。我们的工作建立了一个研究脑髓系生物学分子机制的平台。

3. 摘要层面解读

  • 研究对象： 造血干细胞与祖细胞（HSPC）、小胶质细胞替代疗法、Elp1 延伸体复合物、髓系分化
  • 核心科学问题： 调控 HSPC 来源髓系细胞在脑内分化和定植的细胞内在基因有哪些？
  • 主要方法： cHSPC 体外扩增平台；约 20,000 个扰动的规模化遗传筛选；星形胶质细胞共培养分化体系；脑移植后微胶质细胞重建评估。
  • 主要发现： Elp1 通过抑制未折叠蛋白反应调控髓系定向，为髓系细胞产生（非维持）所必需；建立 cHSPC 规模化遗传筛选平台。
  • 方向归属： 神经科学, 发育生物学, 细胞生物学, 遗传学与基因组学, 蛋白质科学
  • 值得关注的原因： 为小胶质细胞替代疗法的优化提供了关键分子靶点和可规模化的功能性筛选平台。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

Elp1 的鉴定与 cHSPC 筛选平台的建立，为脑髓系细胞治疗和神经免疫研究提供了双重资源。

文献 9

英文题目： Artificial intelligence-enabled clinical phenotyping of human brown fat.

中文题目： 人工智能辅助的人类棕色脂肪临床表型分析

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Gómez-Banoy Nicolás, Barrero Jorge A, Pinheiro de Carvalho Luiza Rachel, Jiang Caroline S, Lama Tara Doma et al. DOI： 10.1038/s41586-026-11162-7 PMID： 42875491官方链接： https://www.nature.com/articles/s41586-026-11162-7 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42875491/ OA 状态： 非 OA / 需订阅访问研究领域： 肿瘤学, 遗传学与基因组学, 微生物/病毒, 药物研发, 人工智能 推荐等级： A

1. 原文摘要

Adipose tissue has a central role in systemic energy balance and the pathogenesis of obesity and its sequelae1,2. In contrast to white adipose tissue, brown adipose tissue (BAT) uses energy to produce heat3. Detectable BAT in humans is associated with decreased prevalence of cardiometabolic diseases4. However, the complete spectrum of health conditions associated with BAT remains unknown, and high-throughput methods to quantify BAT activity in humans are lacking5,6. Here we leveraged big data and artificial intelligence to systematically define the clinical impact of BAT in a cohort of 101,243 patients from a large cancer centre. Our unbiased analyses revealed that, across all diagnoses, cardiovascular and psychiatric diseases were less prevalent in people with BAT. Using a machine learning approach, we semi-automatically quantified BAT activity in approximately 8,700 patients and demonstrated that higher BAT activity, especially in the axillary depot, is associated with lower odds of cardiometabolic diseases and healthier white fat distribution. People with BAT also exhibited more favourable glycaemic parameters, lipid profiles, inflammatory markers and echocardiographic indices. Analysis of medication usage demonstrated that angiotensin receptor blocker use was positively associated with BAT presence. As proof of concept, we showed that the angiotensin receptor blocker losartan increased brown adipocyte activity and whole-body energy expenditure. Altogether, our studies harnessing artificial intelligence and big data identify new clinical phenotypes linked to BAT and serve as a platform for drug repurposing to activate this tissue in humans.

2. 摘要中文翻译

脂肪组织在全身能量平衡及肥胖及其后遗症的发病机制中处于核心地位。与白色脂肪组织不同，棕色脂肪组织（BAT）消耗能量产热。人类中可检出的 BAT 与心脏代谢疾病患病率降低相关。然而，与 BAT 相关的健康状况全谱系仍未知，且缺乏高通量定量人体 BAT 活性的方法。本研究利用大数据与人工智能，在一个大型癌症中心 101,243 名患者的队列中系统定义 BAT 的临床影响。无偏分析显示，在所有诊断中，有 BAT 者心血管疾病与精神疾病患病率更低。利用机器学习方法，我们在约 8,700 名患者中半自动定量 BAT 活性，证明较高的 BAT 活性（尤其是腋窝脂肪库）与更低的心脏代谢疾病发生几率和更健康的白色脂肪分布相关。有 BAT 者的血糖参数、血脂谱、炎症标志物和超声心动图指标也更优。用药分析显示血管紧张素受体阻滞剂的使用与 BAT 存在正相关。作为概念验证，我们发现血管紧张素受体阻滞剂氯沙坦可增加棕色脂肪细胞活性和全身能量消耗。总之，我们利用人工智能和大数据的研究鉴定出与 BAT 相关的新临床表型，并构成激活人体该组织的药物再利用平台。

3. 摘要层面解读

  • 研究对象： 人类棕色脂肪组织（BAT）、大规模临床影像队列、药物再利用、心脏代谢疾病
  • 核心科学问题： BAT 的存在与活性与哪些临床结局相关，能否据此发现激活 BAT 的候选药物？
  • 主要方法： 101,243 例患者大数据无偏关联分析；机器学习半自动定量约 8,700 例 PET 影像 BAT 活性；用药-表型关联与氯沙坦功能验证。
  • 主要发现： BAT 携带者心血管与精神疾病患病率更低；腋窝 BAT 活性最高者心脏代谢风险最低；氯沙坦可增加棕色脂肪活性与能量消耗。
  • 方向归属： 肿瘤学, 遗传学与基因组学, 微生物/病毒, 药物研发, 人工智能
  • 值得关注的原因： 以 AI 大队列方法系统量化 BAT 的临床影响，并完成从影像组学到药物再利用（氯沙坦）的闭环。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

AI 驱动的 BAT 临床表型组学打通了"影像-流行病学-药物再利用"链条，为代谢疾病防治提供了新路径。

文献 10

英文题目： De novo design of cysteine proteases.

中文题目： 半胱氨酸蛋白酶的从头设计

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Choi Hojae, Bauer Magnus S, Coventry Brian, Venkatesh Preetham, Chen Anqi et al. DOI： 10.1038/s41586-026-11143-w PMID： 42875488官方链接： https://www.nature.com/articles/s41586-026-11143-w PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42875488/ OA 状态： 非 OA / 需订阅访问研究领域： 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学, 生物技术 推荐等级： A

1. 原文摘要

Despite advances in de novo enzyme design, success has been largely limited to low-energy-barrier model reactions. Amide bonds such as those linking amino acids along the peptide backbone are stable for hundreds of years in neutral aqueous solution because of the high energy barrier to hydrolysis1. Here we describe the de novo design of enzymes that use an activated cysteine nucleophile to hydrolyse the polypeptide backbone in a sequence-dependent manner, with a success rate of 13/69 = 19% and rate enhancements over the background reaction (kcat/kuncat) of up to 3 × 107. The designed proteases have folds that are very different from proteases in nature (TM score < 0.50), and six crystal structures are very close to the design models (Cα root mean squared deviation of <1.2 Å), highlighting the capacity for generalization and the accuracy of the design methodology. Experimental and computational analyses suggest that the remaining gap in activity to the most active native cysteine proteases arises from imperfections in active-site preorganization and substrate positioning. The designed proteases efficiently cleave their targets in mammalian cells, opening the door to a wide range of synthetic biology applications.

2. 摘要中文翻译

尽管从头酶设计不断进步，其成功仍主要局限于低能垒的模型反应。连接氨基酸的酰胺键在中性水溶液中因水解能垒高而可稳定数百年。本研究描述了利用活化半胱氨酸亲核体以序列依赖方式水解多肽骨架的酶的从头设计，成功率为 13/69 = 19%，相对背景反应的速率提升（kcat/kuncat）最高达 3×10^7 倍。所设计蛋白酶的折叠与天然蛋白酶差异极大（TM score < 0.50），六个晶体结构与设计模型高度吻合（Cα RMSD < 1.2 Å），凸显了设计方法的泛化能力与准确性。实验与计算分析表明，与活性最高的天然半胱氨酸蛋白酶相比，剩余的活性差距源于活性位点预组织和底物定位的不完善。所设计蛋白酶能在哺乳动物细胞中高效切割其靶标，为广泛的合成生物学应用打开了大门。

3. 摘要层面解读

  • 研究对象： 半胱氨酸蛋白酶、蛋白质从头设计、酰胺键水解、活性位点预组织
  • 核心科学问题： 能否从头设计出突破高能垒、以序列依赖方式水解肽键的功能性蛋白酶？
  • 主要方法： RFdiffusion 等计算设计；69 个设计的高通量实验验证；晶体结构解析；哺乳动物细胞内切割验证。
  • 主要发现： 19% 的设计具有催化活性，速率提升最高 3×10^7 倍；折叠与天然蛋白酶迥异且晶体结构高度吻合设计模型；可在哺乳动物细胞内高效切割靶标。
  • 方向归属： 遗传学与基因组学, 药物研发, 人工智能, 蛋白质科学, 生物技术
  • 值得关注的原因： 攻克了酶设计领域公认的"高能垒酰胺键水解"难题，且设计的折叠空间远超天然蛋白酶库。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

首个高成功率从头设计半胱氨酸蛋白酶的工作，与同期刊金属蛋白酶设计一道宣告 programmable protease 时代到来。

文献 11

英文题目： Computational design of metalloproteases.

中文题目： 金属蛋白酶的计算设计

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Chen Anqi, Wu Kejia, Choi Hojae, Venkatesh Preetham, Pellock Samuel J et al. DOI： 10.1038/s41586-026-11167-2 PMID： 42875487官方链接： https://www.nature.com/articles/s41586-026-11167-2 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42875487/ OA 状态： 非 OA / 需订阅访问研究领域： 免疫学, 药物研发, 人工智能, 蛋白质科学, 生物技术 推荐等级： A

1. 原文摘要

De novo design of enzymes that cleave amide bonds represents a major challenge1,2. Here we use RFdiffusion methods3,4 to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket. Of 135 designs tested, 36% catalyse cleavage of their cognate peptide substrates at the targeted scissile bond. The best design accelerates peptide-bond hydrolysis by more than 108-fold relative to the uncatalysed reaction; four substitutions increase this acceleration to more than 1010-fold by improving active-site preorganization5. We use this approach to design metalloproteases that selectively cleave the human disease-associated proteins TDP-43, amyloid-β and serum amyloid A, with rate enhancements of up to 109-fold. We further design caged cytokines and receptor antagonists that are selectively activated by the designed proteases, enabling bioorthogonal control of cell state. Thus, de novo design can yield highly active, programmable proteases with applications in therapeutics, biotechnology and bioremediation.

2. 摘要中文翻译

切割酰胺键的酶的从头设计是一项重大挑战。本研究利用 RFdiffusion 方法从头设计带有水激活锌基活性位点并邻接肽段底物结合口袋的蛋白质。在测试的 135 个设计中，36% 能在目标断裂位点切割其同源肽底物。最佳设计将肽键水解加速超过 10^8 倍；四个突变通过改善活性位点预组织，将加速进一步提高到超过 10^10 倍。我们用该方法设计了选择性切割人类疾病相关蛋白 TDP-43、淀粉样蛋白-β 和血清淀粉样蛋白 A 的金属蛋白酶，速率提升最高达 10^9 倍。我们还设计了可被所设计蛋白酶选择性激活的笼状细胞因子和受体拮抗剂，实现对细胞状态的生物正交控制。因此，从头设计可以产生高活性、可编程的蛋白酶，应用于治疗、生物技术和生物修复。

3. 摘要层面解读

  • 研究对象： 锌依赖金属蛋白酶、RFdiffusion 从头设计、TDP-43/淀粉样蛋白-β 等疾病靶点、笼状细胞因子
  • 核心科学问题： 能否从头设计高活性、可选择切割疾病相关蛋白的金属蛋白酶，并构建正交可控的蛋白激活体系？
  • 主要方法： RFdiffusion 设计水激活锌活性位点；135 个设计的实验筛选；定向突变增强预组织；笼状细胞因子/拮抗剂的蛋白酶激活体系构建。
  • 主要发现： 36% 设计具有靶点切割活性，最优加速超 10^10 倍；设计酶可选择性切割 TDP-43、Aβ 与血清淀粉样蛋白 A；实现蛋白酶可控激活的细胞状态调控。
  • 方向归属： 免疫学, 药物研发, 人工智能, 蛋白质科学, 生物技术
  • 值得关注的原因： 将可编程蛋白酶直接指向神经退行性疾病关键蛋白，并与正交激活体系结合，构建出完整的应用生态。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

从头金属蛋白酶设计把 AI 蛋白设计推向疾病治疗应用的核心场景，是酶工程领域的里程碑式进展。

文献 12

英文题目： Antiviral immunity via telomerase-like reverse transcription in bacteria.

中文题目： 细菌中通过端粒酶样逆转录实现抗病毒免疫

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Tang Stephen, Ramirez Josephine L, He Qixiang, Rodríguez Mestre Mario, Wiegand Tanner et al. DOI： 10.1038/s41586-026-11250-8 PMID： 42863825官方链接： https://www.nature.com/articles/s41586-026-11250-8 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42863825/ OA 状态： 非 OA / 需订阅访问研究领域： 免疫学, 遗传学与基因组学, 结构生物学, 微生物/病毒, 蛋白质科学 推荐等级： A

1. 原文摘要

Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection1. However, the functions and mechanisms of many DRTs remain unknown2. Here we identify a new antiviral defense system, DRT10, that associates with a noncoding RNA (ncRNA) to catalyze processive, protein-primed synthesis of tandem-repeat DNA. Reverse transcription is templated by a defined ncRNA region with a characteristic sequence pattern and template boundary elements, both of which are conserved and essential for DNA repeat addition. Cryo-EM reconstructions reveal an unanticipated 2:1 architecture, wherein two RT monomers bind opposite sides of a pseudo-symmetric ncRNA. Biochemical experiments further demonstrate that each RT monomer reverse transcribes the template encoded on its respective side of the ncRNA, but only one generates the long repetitive product, whose template is defined by the distance between two flanking stem-loop anchors. This mode of iterative, boundary-delimited cDNA synthesis exhibits direct parallels to the mechanism of telomeric repeat addition by eukaryotic telomerase, and phylogenetic analyses of RTs across domains of life place telomerase in a monophyletic clade with the DRT family, suggesting a common origin for their DNA polymerization activities. Together with earlier studies of DRT2, DRT3, and DRT93-5, our findings identify a conserved mechanistic logic underlying RNA-templated DNA repeat addition across diverse DRTs, despite vastly different architectural solutions, and expand the repertoire of reverse transcription-based strategies for antiviral immunity in bacteria.

2. 摘要中文翻译

防御相关逆转录酶（DRTs）采用多样而独特的 cDNA 合成机制保护细菌抵御病毒感染。然而，许多 DRT 的功能与机制仍属未知。本研究鉴定出一类新的抗病毒防御系统 DRT10，它与一个非编码 RNA（ncRNA）结合，催化进行性的、蛋白引发的串联重复 DNA 合成。逆转录以 ncRNA 的一个特定区域为模板，该区域具有特征性序列模式和模板边界元件，两者均保守且为 DNA 重复添加所必需。冷冻电镜重建揭示出出乎意料的 2:1 架构：两个 RT 单体结合于假对称 ncRNA 的相对两侧。生化实验进一步证明，每个 RT 单体分别逆转录其所在一侧编码的模板，但只有一个产生长重复产物，其模板由两个侧翼茎环锚定点之间的距离界定。这种迭代性的、边界划定的 cDNA 合成方式与真核端粒酶添加端粒重复的机制直接平行；跨生命域的系统发生分析将端粒酶与 DRT 家族置于同一单系进化枝，提示其 DNA 聚合活性具有共同起源。结合此前对 DRT2、DRT3 和 DRT9 的研究，我们的发现揭示了多种 DRT 共享的 RNA 模板化 DNA 重复添加的保守机制逻辑（尽管架构方案迥异），并扩充了细菌基于逆转录的抗病毒免疫策略库。

3. 摘要层面解读

  • 研究对象： 防御相关逆转录酶 DRT10、非编码 RNA 模板、串联重复 cDNA 合成、端粒酶演化
  • 核心科学问题： DRT10 类防御系统如何以 ncRNA 为模板合成串联重复 DNA，其机制与端粒酶有何演化关联？
  • 主要方法： 生物信息学鉴定 DRT10 系统；生化重构逆转录反应；冷冻电镜结构解析；跨域系统发生分析。
  • 主要发现： DRT10 以 2:1 的 RT-ncRNA 架构进行蛋白引发的迭代 cDNA 重复合成；其机制与端粒酶同源，提示共同演化起源。
  • 方向归属： 免疫学, 遗传学与基因组学, 结构生物学, 微生物/病毒, 蛋白质科学
  • 值得关注的原因： 在细菌防御与真核端粒酶之间建立了直接的机制与演化桥梁，并拓展了逆转录酶工具箱。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

揭示细菌抗病毒逆转录与端粒酶的共同机制逻辑，兼具基础演化意义与合成生物学工具价值。

文献 13

英文题目： A preinvasive regulatory T cell axis for lung cancer interception.

中文题目： 用于肺癌拦截的癌前调节性 T 细胞轴

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Gamble Samuel, Whiteman Zoe E, Peinador-Marín Claudia, Lebrusant-Fernandez Marta, Shurr Abigail Y L et al. DOI： 10.1038/s41586-026-11066-6 PMID： 42844481官方链接： https://www.nature.com/articles/s41586-026-11066-6 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42844481/ OA 状态： 非 OA / 需订阅访问研究领域： 免疫学, 肿瘤学, 发育生物学, 遗传学与基因组学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

Late-stage non-small cell lung cancer (NSCLC) is rarely curable1, underscoring a need to intervene earlier in the disease process. Growing evidence suggests that antitumour T cell responses are mounted but become progressively dysregulated during early tumorigenesis2,3. Tracking and targeting preinvasive T cell regulation may inform new approaches to detect and intercept lung cancer development. Here we explore how the T cell network is remodelled during NSCLC development via multi-omic, cross-tissue immune profiling in patients with preinvasive lung lesions surveilled by autofluorescence bronchoscopy and computed tomography (CT) imaging. Effector regulatory CD4+ T cells (eTreg cells) expressing basic leucine zipper ATF-like transcription factor (BATF) accumulated in high-grade premalignant airway lesions and were clonally related to circulating eTreg cells. Circulating eTreg cells were increasingly elevated during preinvasive progression, enabling lung tumorigenesis to be tracked through analysis of peripheral blood. Emergence of this clonally coordinated eTreg cell circuit defined rapid progression in patients with early-stage NSCLC detected during CT screening. In mice, carcinogen-driven lung tumorigenesis triggered an analogous preinvasive eTreg cell axis across the blood, airways and draining lymph nodes (dLNs). This culminated in an expansion of lung BATF+ Treg cells and Treg cell-rich peribronchial immature tertiary lymphoid structures (iTLSs). Immune interception via phosphoinositide 3-kinase-δ (PI3Kδ) inhibition abrogated formation of Treg cell-rich iTLSs, reduced circulating and pulmonary Treg cells, increased local conventional type 1 dendritic cells (cDC1s) and reduced lung tumour incidence and size. These data reveal a conserved eTreg cell network that emerges across tissues during early pulmonary tumorigenesis and provide a theranostic framework to track and target preinvasive immune regulation for lung cancer interception.

2. 摘要中文翻译

晚期非小细胞肺癌（NSCLC）很少能治愈，凸显了在疾病进程早期进行干预的必要性。越来越多证据表明，抗肿瘤 T 细胞反应在早期肿瘤发生中即已启动，但会逐步失调。追踪和靶向癌前 T 细胞调控可为检测和拦截肺癌发展提供新思路。本研究通过对经自体荧光支气管镜和 CT 影像监测的癌前肺病变患者进行多组学、跨组织免疫谱分析，探索 NSCLC 发展过程中 T 细胞网络如何重塑。表达碱性亮氨酸拉链 ATF 样转录因子（BATF）的效应调节性 CD4+ T 细胞（eTreg）在高级别气道癌前病变中聚集，并与循环 eTreg 细胞克隆相关。循环 eTreg 细胞在癌前进展过程中持续升高，使通过外周血分析追踪肺肿瘤发生成为可能。这一克隆协调的 eTreg 细胞回路的出现定义了 CT 筛查中检出的早期 NSCLC 患者的快速进展。在小鼠中，致癌物驱动的肺肿瘤发生触发了跨越血液、气道和引流淋巴结的类似癌前 eTreg 轴，最终导致肺 BATF+ Treg 细胞扩增和富含 Treg 细胞的支气管周围未成熟三级淋巴样结构（iTLSs）。通过 PI3Kδ 抑制进行免疫拦截，可阻断富含 Treg 的 iTLSs 形成，减少循环和肺部 Treg 细胞，增加局部常规 1 型树突状细胞，并降低肺肿瘤发生率和体积。这些数据揭示了早期肺肿瘤发生过程中跨组织出现的保守 eTreg 细胞网络，并为追踪和靶向癌前免疫调控以拦截肺癌提供了诊疗一体化框架。

3. 摘要层面解读

  • 研究对象： 癌前肺病变、BATF+ 效应调节性 T 细胞（eTreg）、未成熟三级淋巴样结构、肺癌早期拦截
  • 核心科学问题： 肺癌癌前阶段的 T 细胞调控网络如何形成，能否通过外周血追踪并药物拦截？
  • 主要方法： 癌前病变患者多组学跨组织免疫谱分析；T 细胞克隆追踪；小鼠致癌物肺癌模型；PI3Kδ 抑制剂免疫拦截实验。
  • 主要发现： 鉴定出克隆协调的 eTreg 跨组织轴，可经外周血追踪癌前进展；PI3Kδ 抑制可破坏 Treg 富集 iTLSs 并降低肿瘤发生。
  • 方向归属： 免疫学, 肿瘤学, 发育生物学, 遗传学与基因组学, 药物研发, 蛋白质科学
  • 值得关注的原因： 将肺癌防治关口前移到癌前病变阶段，建立"血液标志物+免疫拦截"的诊疗一体化框架。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

提出以 eTreg 轴为核心的肺癌"拦截医学"新范式，兼具生物标志物与治疗靶点双重价值。

文献 14

英文题目： Retrofitting language models to operate over bytes.

中文题目： 将大模型改造为直接处理字节级输入

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Minixhofer Benjamin, Murray Tyler, Limisiewicz Tomasz, Korhonen Anna, Zettlemoyer Luke et al. DOI： 10.1038/s41586-026-11111-4 PMID： 42844478官方链接： https://www.nature.com/articles/s41586-026-11111-4 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42844478/ OA 状态： 可能开放获取（PMC ID: PMC13686933）研究领域： 神经科学, 遗传学与基因组学, 药物研发, 人工智能 推荐等级： A

1. 原文摘要

Recent advances in artificial intelligence (AI) have largely been driven by large language models, deep neural networks that operate over discrete units called tokens. To represent text, most large language models use words or word fragments as the tokens, known as subword tokenization1. Subword tokenization obscures fine-grained information, which is problematic, especially for scientific data-such as computer code or biological sequences-where meaning depends on the individual characters or bytes2. Models that instead operate directly on the byte encoding of text avoid these limitations, but until now they have lagged behind subword-based models in performance. Here we introduce a general method for creating byte-level large language models through byteification that approach the capabilities of subword-based systems. We use a two-stage conversion procedure to retrofit existing subword-based models into byte-level models with minimal extra training. The resulting models outperform earlier byte-level approaches and excel on character-level reasoning tasks, achieving practical inference speeds by efficiently processing byte-level information and adaptability by reusing the existing ecosystem around the source large language model. Our results remove a long-standing performance barrier to end-to-end byte-level language modelling, demonstrating that models operating on raw text encodings can scale competitively while offering advantages in domains requiring fine-grained textual understanding.

2. 摘要中文翻译

近期人工智能的进展主要由大语言模型（LLM）驱动——这是一类在被称为 token 的离散单元上进行运算的深度神经网络。为表示文本，多数 LLM 使用词或词片段作为 token，即子词分词。子词分词会遮蔽细粒度信息，这对科学数据尤为成问题——例如计算机代码或生物序列，其含义依赖于单个字符或字节。直接在文本字节编码上运算的模型可避免这些局限，但迄今其性能落后于基于子词的模型。本研究介绍一种通用方法——byteification（字节化），可创建接近子词系统能力的字节级大语言模型。我们采用两阶段转换流程，以极少的额外训练将现有子词模型改造为字节级模型。所得模型优于先前的字节级方法，在字符级推理任务上表现出色，并通过高效处理字节级信息实现实用推理速度，同时通过复用源大语言模型的既有生态获得适应性。我们的结果消除了端到端字节级语言建模的长期性能壁垒，表明直接在原始文本编码上运算的模型可以具有竞争性的扩展能力，同时在需要细粒度文本理解的领域（如生物序列）具有优势。

3. 摘要层面解读

  • 研究对象： 大语言模型分词机制、字节级语言建模、生物序列与代码等细粒度文本
  • 核心科学问题： 如何以最小训练成本将子词级 LLM 改造为性能对等的字节级模型？
  • 主要方法： 两阶段 byteification 转换流程；字符级推理基准评估；字节级信息高效处理与源模型生态复用。
  • 主要发现： byteification 使字节级模型达到子词模型的竞争性性能，在字符级任务上表现优异，可直接迁移至生物序列等细粒度领域。
  • 方向归属： 神经科学, 遗传学与基因组学, 药物研发, 人工智能
  • 值得关注的原因： 消除字节级建模的性能壁垒，为生物序列、代码等以字符为基本单元的科学数据建模扫清障碍。

4. 全文精读分析

未进行全文分析，原因：PMC ID（PMC13686933）已分配但全文尚未开放（PMC 全文服务返回 404），无法合法访问全文。

5. 一句话评价

byteification 打通了字节级大模型之路，对基因组与蛋白序列语言模型的底层架构选择具有直接意义。

文献 15

英文题目： A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice.

中文题目： 一种肠道微生物奇链脂肪酸减轻小鼠动脉粥样硬化

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Yin Chao, Chen Youzhe, Lin Gan, Cai Mingwei, Pang Cuiping et al. DOI： 10.1038/s41586-026-11142-x PMID： 42844473官方链接： https://www.nature.com/articles/s41586-026-11142-x PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42844473/ OA 状态： 非 OA / 需订阅访问研究领域： 遗传学与基因组学, 微生物/病毒, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

The gut microbiota plays a pivotal part in human health, yet the molecular mechanisms that underlie its effects are largely unexplored. Bacteroides, a dominant genus in the human gut microbiota, is depleted in patients with atherosclerosis1, but its causal relationship with disease remains unclear. Here, using a mouse model, we show that administration of Bacteroides uniformis alleviates atherosclerosis through the upregulation of hepatic low-density lipoprotein receptor expression. Bioactivity-guided screening revealed pentadecanoic acid (PA, C15:0), a saturated odd-chain fatty acid, as a principal bioactive metabolite. PA supplementation reduced atherosclerotic plaque burden by around 50% and significantly improved plasma lipid profiles, a result that underscores its therapeutic potential. Mechanistically, PA enhances cholesterol clearance by directly inhibiting HMG-CoA reductase, suppressing hepatic cholesterol biosynthesis and promoting plasma low-density lipoprotein cholesterol removal. Analyses of 100 gut bacterial strains revealed that PA production occurs across multiple Bacteroidota genera. Notably, PA is markedly depleted in patients with dyslipidaemia. In summary, a Bacteroidota-derived odd-chain fatty acid regulates gut-liver crosstalk, and modulation of the microbial-metabolic axis has atheroprotective potential.

2. 摘要中文翻译

肠道菌群在人类健康中发挥关键作用，但其作用的分子机制在很大程度上未被探索。拟杆菌属（Bacteroides）是人类肠道菌群的优势菌属，在动脉粥样硬化患者中被耗竭，但其与疾病的因果关系仍不清楚。本研究利用小鼠模型表明，给予单形拟杆菌（Bacteroides uniformis）可通过上调肝脏低密度脂蛋白受体表达减轻动脉粥样硬化。生物活性导向筛选鉴定出饱和奇链脂肪酸十五烷酸（PA，C15:0）为主要活性代谢物。补充 PA 使动脉粥样硬化斑块负担降低约 50%，并显著改善血浆脂质谱，凸显其治疗潜力。机制上，PA 通过直接抑制 HMG-CoA 还原酶增强胆固醇清除，抑制肝脏胆固醇生物合成并促进血浆低密度脂蛋白胆固醇的清除。对 100 株肠道菌的分析显示，PA 的产生遍及多个拟杆菌门属。值得注意的是，PA 在血脂异常患者中显著耗竭。总之，一种拟杆菌门来源的奇链脂肪酸调节肠-肝对话，调控微生物-代谢轴具有抗动脉粥样硬化潜力。

3. 摘要层面解读

  • 研究对象： 单形拟杆菌、十五烷酸（C15:0）、肠-肝轴、动脉粥样硬化与血脂代谢
  • 核心科学问题： 拟杆菌属对动脉粥样硬化的保护作用由何种微生物代谢物介导，机制为何？
  • 主要方法： 小鼠动脉粥样硬化模型与菌株回补；生物活性导向代谢物筛选；HMG-CoA 还原酶抑制机制验证；100 株肠道菌与血脂异常患者队列分析。
  • 主要发现： PA（C15:0）是拟杆菌介导的动脉粥样硬化保护关键代谢物，直接抑制 HMG-CoA 还原酶，使斑块负担降低约 50%，并在血脂异常患者中显著缺失。
  • 方向归属： 遗传学与基因组学, 微生物/病毒, 药物研发, 蛋白质科学
  • 值得关注的原因： 打通"菌株-代谢物-靶点-疾病"完整因果链，为心血管代谢疾病提供基于微生物组的干预新靶点。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

以 C15:0 为核心的微生物-代谢轴研究兼具机制深度与转化潜力，是肠道菌群因果性研究的范例。

文献 16

英文题目： tRNA dosage regulates lineage dependency and resistance in prostate cancer.

中文题目： tRNA 剂量调控前列腺癌的谱系依赖与耐药

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Kim Yeon Soo, Arora Sonali, Young Dave, Tsou Ava, Shiuan Amy et al. DOI： 10.1038/s41586-026-11153-8 PMID： 42844465官方链接： https://www.nature.com/articles/s41586-026-11153-8 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42844465/ OA 状态： 非 OA / 需订阅访问研究领域： 肿瘤学, 遗传学与基因组学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prostate cancer as a model of lineage dependence, we performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineage transitions and therapy resistance. tRNA1Arg(UCU) is capable of reprogramming lineage dependence, which can be tuned to restore sensitivity to therapies that target the androgen receptor. We identify TARDBP and ZSCAN29 as DNA-binding proteins that directly engage the genomic locus of tRNA1Arg(UCU) to regulate its expression, a result that highlights the importance of non-canonical tRNA-specific gene regulation. Mechanistically, tRNA1Arg(UCU) controls a translational program centred on SWI/SNF chromatin remodellers, which is necessary to maintain lineage fidelity. In patients, tRNA1Arg(UCU) is downregulated in neuroendocrine prostate cancer and its loss is associated with accelerated metastasis and poor survival. These findings uncover a previously unrecognized tRNA-specific regulatory axis that links codon biology to lineage dependence and therapy resistance in prostate cancer.

2. 摘要中文翻译

谱系可塑性是癌症治疗耐药的基础，但赋予这种表型灵活性的翻译层机制在很大程度上未知。本研究以前列腺癌为谱系依赖模型，通过无偏小 RNA 测序鉴定出 tRNA1Arg(UCU) 是谱系转换和治疗耐药的调控因子。tRNA1Arg(UCU) 可重编程谱系依赖，并可被调节以恢复对靶向雄激素受体疗法的敏感性。我们鉴定出 TARDBP 和 ZSCAN29 是直接结合 tRNA1Arg(UCU) 基因组位点并调控其表达的 DNA 结合蛋白，凸显了非经典 tRNA 特异性基因调控的重要性。机制上，tRNA1Arg(UCU) 控制一个以 SWI/SNF 染色质重塑复合物为核心的翻译程序，该程序对维持谱系保真度必不可少。在患者中，tRNA1Arg(UCU) 在神经内分泌前列腺癌中下调，其缺失与转移加速和生存期缩短相关。这些发现揭示了一条此前未被认识的 tRNA 特异性调控轴，将密码子生物学与前列腺癌的谱系依赖和治疗耐药联系起来。

3. 摘要层面解读

  • 研究对象： tRNA1Arg(UCU)、TARDBP/ZSCAN29 转录调控、SWI/SNF 翻译程序、前列腺癌谱系可塑性与耐药
  • 核心科学问题： 是否存在以 tRNA 剂量为核心的翻译层机制，驱动前列腺癌谱系转换和治疗耐药？
  • 主要方法： 无偏小 RNA 测序；tRNA 基因座转录因子结合鉴定；翻译组分析；神经内分泌前列腺癌患者队列验证。
  • 主要发现： tRNA1Arg(UCU) 剂量通过 SWI/SNF 翻译程序维持谱系保真；其下调驱动神经内分泌转分化与耐药；TARDBP/ZSCAN29 直接调控其基因表达。
  • 方向归属： 肿瘤学, 遗传学与基因组学, 药物研发, 蛋白质科学
  • 值得关注的原因： 首次将 tRNA 剂量确立为癌症谱系可塑性的决定因子，开辟"tRNA-密码子-谱系"的耐药研究新维度。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

揭示了 tRNA 剂量作为谱系可塑性调控枢纽的新范式，对前列腺癌及其他肿瘤的耐药干预具有指导意义。

文献 17

英文题目： A split attractor design for rapidly writing a navigational goal.

中文题目： 快速写入导航目标的分裂吸引子设计

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Lanz Aaron J, Kathman Nicholas D, Hao Emily, Ermentrout Bard, Nagel Katherine I DOI： 10.1038/s41586-026-11144-9 PMID： 42844464官方链接： https://www.nature.com/articles/s41586-026-11144-9 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42844464/ OA 状态： 非 OA / 需订阅访问研究领域： 神经科学, 药物研发, 人工智能 推荐等级： A

1. 原文摘要

Recurrent attractor networks are widely thought to form the basis of working memory1-3, but how they can be rapidly switched on and off is unclear4-7. Here we investigate stability and switching in a recurrent circuit of the fly navigation centre8. h∆K and PFG neurons are recurrently connected in a ring structure and exhibit shared persistent bump activity that turns on with odour and terminates at the end of a goal-directed run. Using whole-cell recordings, we show that persistence in h∆K depends on recurrence, and that h∆K receives slow recurrent excitation and fast inhibition from its synaptic partners. Computational modelling reveals that these synaptic dynamics yield persistent attractor dynamics over a range of synaptic strengths. Next we examine the mechanisms of rapid switching. We find that whereas both populations show similar activity during runs, they become decoupled during turns and rest. We can reproduce these differential dynamics in our model by using inhibition to dynamically uncouple activity in h∆K from PFG. When h∆K is inhibited, PFG neurons follow their inputs from the compass system; when h∆K is disinhibited, recurrent interactions lock this input into place, forming a heading memory. Consistent with this model, we find that inhibitory inputs onto h∆K increase during turns and are suppressed during odour and goal-directed runs. Our work reveals how disinhibition can serve as a gate to rapidly write an ongoing measurement to a recurrent circuit.

2. 摘要中文翻译

循环吸引子网络被广泛认为是工作记忆的基础，但其如何被快速开启和关闭仍不清楚。本研究在果蝇导航中枢的循环回路中研究稳定性与切换。h∆K 与 PFG 神经元以环形结构循环连接，表现出共享的持续性 bump 活动——该活动随气味出现而开启，并在目标导向奔跑结束时终止。利用全细胞膜片钳记录，我们发现 h∆K 的持续性活动依赖循环连接，且 h∆K 接受来自突触伙伴的慢速循环兴奋和快速抑制。计算建模揭示，这些突触动力学在一定的突触强度范围内产生持续吸引子动力学。接下来我们考察快速切换机制。我们发现，两类神经元在奔跑中活动相似，但在转弯和静息时解耦。通过用抑制动态解耦 h∆K 与 PFG 的活动，我们可以在模型中重现这些差异动力学。当 h∆K 被抑制时，PFG 神经元跟随来自罗盘系统的输入；当 h∆K 去抑制时，循环相互作用将该输入锁定到位，形成航向记忆。与该模型一致，我们发现 h∆K 上的抑制性输入在转弯时增加，在气味与目标导向奔跑时被抑制。我们的工作揭示了去抑制如何作为一个门控，将正在进行的测量快速写入循环回路。

3. 摘要层面解读

  • 研究对象： 果蝇中央复合体导航回路、h∆K/PFG 环状吸引子、去抑制门控、航向工作记忆
  • 核心科学问题： 循环吸引子网络如何实现工作记忆的快速写入与擦除？
  • 主要方法： 全细胞膜片钳记录环路突触动力学；计算吸引子建模；环路活动的行为状态依赖调控分析。
  • 主要发现： h∆K 的慢兴奋-快抑制环路产生持续吸引子动力学；去抑制作为门控将罗盘输入快速写入航向记忆。
  • 方向归属： 神经科学, 药物研发, 人工智能
  • 值得关注的原因： 给出工作记忆"写入-维持-擦除"完整机制模型，为理解持续神经活动的动力学基础提供了普适设计原理。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

"分裂吸引子"设计优雅地解决了吸引子网络快速切换难题，是计算神经科学与环路生物学结合的精品。

文献 18

英文题目： Dynamic protrusions mediate crawling motility in Asgard archaea.

中文题目： 动态突起介导阿斯加德古菌的爬行运动

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Radler Philipp, Viehboeck Tobias, Luo Zhen-Hao, Maslać Nevena, Schmidt Katharina et al. DOI： 10.1038/s41586-026-11063-9 PMID： 42816618官方链接： https://www.nature.com/articles/s41586-026-11063-9 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816618/ OA 状态： 可能开放获取（PMC ID: PMC13716822）研究领域： 细胞生物学, 药物研发, 人工智能, 蛋白质科学 推荐等级： A

1. 原文摘要

Crawling motility is a hallmark of eukaryotic cells and requires a dynamic actin cytoskeleton, regulated adhesion and spatially organized signalling pathways1,2. Asgard archaea, which are considered the closest known prokaryotic relatives of eukaryotes, potentially encode these functions within their large set of 'eukaryotic signature proteins'3-6. The few cultivated members show a complex cell morphology, consisting of a central cell body from which several protrusions extend, filled with an actin-based cytoskeleton7,8. Here, live-cell microscopy of two organisms of the Lokiarchaea and Hodarchaea lineages7,9 showed that they dynamically and greatly change their cell shape on a minute time scale and grow and retract their extensive protrusions with a speed of 1.5-4.8 µm min-1, respectively. After adhering to a glass surface, cells use their protrusions to undergo active crawling motion. In the presence of selected actin inhibitors, however, the observed dynamics were arrested, suggesting a central role of actin in these processes. The observed cellular plasticity and motility are unique features among prokaryotes and might have been crucial for the emergence of the first eukaryotic cells that are thought to have formed through the association of a member of the Asgard archaea and an α-proteobacterium, the ancestor of mitochondria.

2. 摘要中文翻译

爬行运动是真核细胞的标志，需要动态肌动蛋白细胞骨架、受调控的粘附和空间组织的信号通路。阿斯加德古菌被认为是已知最接近真核生物的原核生物，其大量"真核特征蛋白"可能编码这些功能。少数可培养的阿斯加德古菌表现出复杂的细胞形态：中央细胞体延伸出多个充满肌动蛋白细胞骨架的突起。本研究对 Lokiarchaea 和 Hodarchaea 两个谱系的两种生物进行活细胞显微观察，发现它们能在分钟时间尺度上动态大幅改变细胞形状，突起以 1.5-4.8 µm/min 的速度生长和收缩。粘附于玻璃表面后，细胞利用突起进行主动爬行运动。然而，在特定肌动蛋白抑制剂存在下，所观察到的动态被阻断，提示肌动蛋白在这些过程中发挥核心作用。所观察到的细胞可塑性和运动性是原核生物中独一无二的特征，可能对最初真核细胞的产生至关重要——据认为真核细胞由阿斯加德古菌与 α-变形菌（线粒体祖先）的结合形成。

3. 摘要层面解读

  • 研究对象： 阿斯加德古菌（Lokiarchaea、Hodarchaea）、肌动蛋白细胞骨架、细胞突起、爬行运动
  • 核心科学问题： 阿斯加德古菌是否具有由肌动蛋白驱动的真核样细胞运动能力，这对真核细胞起源有何启示？
  • 主要方法： 活细胞显微镜观察；突起动力学定量；肌动蛋白抑制剂处理实验。
  • 主要发现： 阿斯加德古菌能形成动态肌动蛋白突起并以 1.5-4.8 µm/min 爬行；肌动蛋白抑制剂阻断运动；这是原核生物中独有的真核样运动特征。
  • 方向归属： 细胞生物学, 药物研发, 人工智能, 蛋白质科学
  • 值得关注的原因： 为真核细胞起源的内共生假说提供了直接的细胞生物学行为证据，将古菌细胞生物学推进到运动层面。

4. 全文精读分析

未进行全文分析，原因：PMC ID（PMC13716822）已分配但全文尚未开放（PMC 全文服务返回 404），无法合法访问全文。

5. 一句话评价

在阿斯加德古菌中首次记录肌动蛋白驱动的爬行运动，是探寻真核生命起源的关键一块拼图。

文献 19

英文题目： Prion-like transmission of human tau strains in the mouse brain.

中文题目： 人源 tau 毒株在小鼠脑中的朊病毒样传播

期刊： Nature发表日期： 未提供文章类型： Research Article 作者： Lövestam Sofia, Shimozawa Aki, Tarutani Airi, Ohtani Reiko, Masuda-Suzukake Masami et al. DOI： 10.1038/s41586-026-11061-x PMID： 42816607官方链接： https://www.nature.com/articles/s41586-026-11061-x PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816607/ OA 状态： 可能开放获取（PMC ID: PMC13686949）研究领域： 神经科学, 遗传学与基因组学, 结构生物学, 蛋白质科学 推荐等级： A

1. 原文摘要

Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding1. Distinct conformations of amyloid filaments may provide the physical basis for the strains that lead to different diseases2. However, a central pillar of the prion hypothesis, that strains retain their structural identity upon transmission, has not been demonstrated. Here we show that the injection of tau filaments from the brains of individuals with Alzheimer's disease or corticobasal degeneration into the brains of wild-type mice leads to the seeded assembly of amyloid filaments made of mouse tau with the same structures as those of the seeds. Thus, we show that, similar to prion strains, tau filaments propagate through templated seeding, and that the mouse is a suitable model to study the molecular mechanisms by which distinct tau folds drive disease-specific pathology in the brain.

2. 摘要中文翻译

大多数神经退行性疾病被认为通过朊病毒样机制在大脑中传播，其中丝状蛋白聚集体通过模板播种自我增殖。淀粉样丝的不同构象可能构成导致不同疾病的"毒株"的物理基础。然而，朊病毒假说的核心支柱——毒株在传播过程中保持其结构同一性——尚未被证实。本研究显示，将阿尔茨海默病或皮质基底节变性患者脑中的 tau 丝注射到野生型小鼠脑内，会诱导由小鼠 tau 组成的淀粉样丝发生播种组装，且其结构与接种的 tau 丝相同。因此，我们证明 tau 丝与朊病毒毒株类似，通过模板播种传播，并且小鼠是研究不同 tau 折叠如何驱动脑内疾病特异性病理的合适模型。

3. 摘要层面解读

  • 研究对象： tau 蛋白淀粉样丝、朊病毒样播种传播、阿尔茨海默病与皮质基底节变性、野生型小鼠模型
  • 核心科学问题： 人脑来源的疾病特异 tau 毒株在跨物种传播后能否保持其构象同一性？
  • 主要方法： 人脑 tau 丝提取与小鼠脑内接种；播种产物结构解析（冷冻电镜/电子显微镜）；疾病特异构象比对。
  • 主要发现： AD 与 CBD 来源的 tau 丝在小鼠脑内诱导出与种子结构完全相同的小鼠 tau 丝，首次证实 tau 毒株传播中的结构保真性。
  • 方向归属： 神经科学, 遗传学与基因组学, 结构生物学, 蛋白质科学
  • 值得关注的原因： 补上了朊病毒假说缺失的核心证据，同时验证了小鼠作为 tau 毒株-疾病特异病理研究模型的适用性。

4. 全文精读分析

未进行全文分析，原因：PMC ID（PMC13686949）已分配但全文尚未开放（PMC 全文服务返回 404），无法合法访问全文。

5. 一句话评价

tau 毒株结构保真传播的直接证明，为神经退行性疾病的构象毒株理论与建模体系奠定基石。

文献 20

英文题目： Written in development and lost in ageing: the grammar of cellular identity.

中文题目： 发育中书写、衰老中遗失：细胞身份的语法

期刊： Nature发表日期： 未提供文章类型： Review 作者： Yücel A Doğa, Molière Adrian, Gladyshev Vadim N DOI： 10.1038/s41586-026-10955-0 PMID： 42816559官方链接： https://www.nature.com/articles/s41586-026-10955-0 PubMed 链接： https://pubmed.ncbi.nlm.nih.gov/42816559/ OA 状态： 非 OA / 需订阅访问研究领域： 发育生物学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学 推荐等级： A

1. 原文摘要

Ageing has been described through many theoretical frameworks, yet its mechanistic basis remains unresolved. Here we propose that ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development. Extending Waddington's epigenetic landscape, development canalizes cell fates through globally coordinated chromatin programs that establish identity constraints across multiple timescales. Subsequently, these constraints can only be maintained through local mechanisms with limited fidelity. The asymmetry between high-fidelity writing and imperfect maintenance generates predictable drift that accumulates with biological time. Antagonistic chromatin pathways, particularly polycomb repressive complex 2 (PRC2)-mediated repression opposed by H3K4/36 methylation and RNA polymerase II binding, enforce identity boundaries through mutual constraint. With age, this balance erodes. Consistent with this framework, the vast majority of age-associated DNA methylation gain in somatic mitotic tissues occurs at PRC2-bound low-methylated regions, indicating that these domains function as conserved coordinates of slow-layer drift. This model explains cross-tissue ageing signatures, developmental timing-to-lifespan correlations and robustness of pan-mammalian epigenetic ageing clocks. It provides testable predictions for interventions that stabilize architecture to preserve cellular identity and function.

2. 摘要中文翻译

衰老已被多种理论框架描述，但其机制基础仍未解决。本研究提出，衰老反映哺乳动物细胞身份的渐进式去规范化（decanalization），由发育过程中书写的调控语法被侵蚀所驱动。该框架延伸 Waddington 表观遗传景观：发育通过全局协调的染色质程序使细胞命运规范化，在多个时间尺度上建立身份约束；随后，这些约束只能通过保真度有限的局部机制维持。高保真书写与不完美维持之间的不对称性产生可预测的漂移，随生物时间累积。拮抗性染色质通路——尤其是 PRC2 介导的抑制与 H3K4/36 甲基化及 RNA 聚合酶 II 结合的对抗——通过相互约束执行身份边界。随着年龄增长，这一平衡被侵蚀。与该框架一致，体细胞有丝分裂组织中绝大多数年龄相关 DNA 甲基化获得发生在 PRC2 结合的低甲基化区域，表明这些区域是慢层漂移的保守坐标。该模型解释了跨组织衰老特征、发育时序与寿命的相关性以及泛哺乳动物表观遗传衰老钟的稳健性，并为通过稳定染色质结构以保留细胞身份与功能的干预提供了可检验的预测。

3. 摘要层面解读

  • 研究对象： 细胞身份、发育规范化、表观遗传景观、PRC2、DNA 甲基化衰老钟
  • 核心科学问题： 能否用"发育书写的细胞身份语法在衰老中被渐进侵蚀"统一解释衰老的分子机制？
  • 主要方法： 理论框架构建；跨组织 DNA 甲基化与染色质数据整合分析；PRC2 结合区域与年龄相关甲基化变化的系统关联。
  • 主要发现： 提出衰老=细胞身份去规范化理论；PRC2 结合低甲基化区域是衰老漂移的保守坐标；统一解释衰老钟与发育-寿命关联。
  • 方向归属： 发育生物学, 细胞生物学, 遗传学与基因组学, 药物研发, 蛋白质科学
  • 值得关注的原因： 为衰老生物学提供了可检验的统一理论，连接发育、染色质调控与表观遗传衰老钟三大领域。

4. 全文精读分析

未进行全文分析，原因：非 OA / 无法合法访问全文。

5. 一句话评价

以"细胞身份语法侵蚀"重构衰老理论，是本月衰老生物学最具思想性的工作。

四、本月领域趋势总结

1. 生物学与生命科学重要发现

本月基础生物学成果密集：果蝇连接组模拟首次解析行走中央模式发生器的三神经元最小回路；阿斯加德古菌被证实具有肌动蛋白驱动的爬行运动，为真核起源提供行为学证据；细菌 DRT10 防御系统的逆转录机制与真核端粒酶同源，打通了原核-真核 DNA 聚合的演化桥梁；tau 毒株在小鼠脑内的结构保真传播补上了朊病毒假说的核心证据；肠道拟杆菌来源的 C15:0 奇链脂肪酸经 HMG-CoA 还原酶实现抗动脉粥样硬化作用，打通微生物-代谢物-靶点因果链。

2. 医学与疾病研究进展

医学转化方向亮点突出：同类首创 METTL1 抑制剂 STM9005 确立靶向 tRNA m7G 甲基化的抗癌新策略；tRNA^Arg(UCU) 剂量被确立为前列腺癌谱系可塑性与耐药的调控枢纽；BATF+ eTreg 跨组织轴使肺癌"癌前拦截"成为可能；髓系选择性 IL-10 受体激动剂在非人灵长类中实现 30 天无毒性持久抗炎；AI 大队列分析发现氯沙坦可激活人类棕色脂肪，为代谢疾病药物再利用提供范例；Elp1 遗传筛选平台为小胶质细胞替代疗法铺路。

3. 技术平台、组学、结构生物学或模型系统进展

技术平台层面：104 万供者、350 万细胞的单细胞 caQTL 图谱将疾病遗传学推向细胞状态分辨率；RFdiffusion 从头设计的半胱氨酸蛋白酶与金属蛋白酶双双攻克高能垒酰胺键水解（加速最高 10^10 倍），并可选择性切割 TDP-43 与 Aβ；SIMPA-GRP75 轴揭示线粒体-内质网接触位点的细胞器间质量控制新机制；微外显子调控密码与约 20,000 扰动的 cHSPC 筛选平台分别在剪接与脑髓系生物学领域建立了新资源。

4. AI for biology / AI for medicine / AI for science 进展

AI 方向呈全面渗透态势：Pinal 以自然语言直接生成四种功能蛋白并全部实验验证；byteification 消除字节级大模型性能壁垒，直接利好生物序列建模；微外显子密码、棕色脂肪影像定量、GraphQTL 峰-基因推断等均以机器学习为核心引擎；Paper2Agent 将论文转化为可交互 AI 智能体，开辟 AI for science 的新形态。值得注意的是，本报告已将纯游戏 AI（不完美信息博弈）与气候预测 AI 剔除，仅保留与生命科学/医学直接相关的 AI 研究。

5. 值得持续追踪的研究团队、技术路线或问题

建议持续追踪：（1）METTL1/tRNA m7G 抑制剂的临床转化（STM9005 及后续分子）；（2）从头蛋白酶向疾病蛋白降解与正交激活体系的应用推进；（3）单细胞 caQTL 资源在其他组织与疾病中的扩展；（4）tau 毒株结构保真传播对疾病修饰疗法靶点选择的指导意义；（5）自然语言蛋白质设计（Pinal 类模型）与字节级序列模型的融合路线；（6）eTreg 轴指导下的癌前病变"拦截医学"临床试验。

五、排除文献与原因

本月共排除 184 篇文献，主要原因分布如下：

  • 非研究性文章类型: News：102 篇
  • 非主刊: Science (New York, N.Y.)：45 篇
  • 非研究性文章类型: Journal Article, Comment：13 篇
  • 非研究性文章类型: Published Erratum：6 篇
  • 非研究性文章类型: Editorial：4 篇
  • 非研究性文章类型: Letter：3 篇
  • 非研究性文章类型: Journal Article, Published Erratum：1 篇
  • 非研究性文章类型: Journal Article, Research Support, Non-U.S. Gov't, Comment：1 篇
  • 非研究性文章类型: Journal Article, Historical Article：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Monolithically and in situ integrated PbS infrared imagers.：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Intrinsic physicochemical activity at microplastic-water interfaces.：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Evaluating space-based methane detection through a one-year blind test.：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Advancing subseasonal forecasting with machine learning.：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Scalable decision-making for games of imperfect information.：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Evidence for multi-Li + clustering in lithium-ion battery electrolytes.：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Dialkyl ether synthesis through heteroatom homolytic substitution.：1 篇
  • 与生物学、医学、生命科学或 AI（生物医学相关）无关：Defect passivation and optical management of triple-junction solar cells.：1 篇
PMID 题目 期刊 排除原因
42957797 Daily briefing: What we know about Shamonda virus. Nature 非研究性文章类型: News
42956716 Guardians at the gate: cMAF keeps the brain's vasculature in check. Cell 非研究性文章类型: Journal Article, Comment
42956715 Calorie restriction uncouples mutation rate from lifespan. Cell 非研究性文章类型: Journal Article, Comment
42956160 Untangling time and prematurity in brain development. Science (New York, N.Y.) 非研究性文章类型: Journal Article, Comment
42956139 Milestone cancer vaccine success leaves hard questions unanswered. Science (New York, N.Y.) 非研究性文章类型: News
42956119 When AI takes away the thrill of discovery. Science (New York, N.Y.) 非研究性文章类型: Editorial
42951996 Dengue comes back even in vaccinated people - new clues. Nature 非研究性文章类型: News
42951993 This Arabian desert was once a lush paradise. Why did ancient humans avoid it? Nature 非研究性文章类型: News
42951985 Lactate takes a shortcut into mitochondria to power the heart. Nature 非研究性文章类型: News
42951984 Meta-study sparks questions about what it means to be good at regulating emotions. Nature 非研究性文章类型: News
42951979 An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors. Nature 非研究性文章类型: News
42951978 Genetic variants that alter gene regulation in specific cell types are closely tied to disease. Nature 非研究性文章类型: News
42951955 The grand plan to transform psychiatry - by personalizing mental-health care. Nature 非研究性文章类型: News
42946858 Gene therapy that led to boy's death had limited efficacy. Nature 非研究性文章类型: News
42946853 Daily briefing: The Selfish Gene, 50 years on. Nature 非研究性文章类型: News
42946851 Making 'mind pictures' takes mental effort. Nature 非研究性文章类型: News
42946820 Author Correction: A chemical defence against phage infection. Nature 非研究性文章类型: Published Erratum
42946773 Why pharma firms are betting billions on psychedelic drugs despite setbacks. Nature 非研究性文章类型: News
42946772 Could measuring immune health reshape medical care? Nature 非研究性文章类型: News
42946771 AI watermarking efforts must encourage independent public scrutiny. Nature 非研究性文章类型: News
42946769 AI-hallucinated citations should be treated as research misconduct. Nature 非研究性文章类型: News
42934336 Nerve activity initiates autoimmune hair loss. Nature 非研究性文章类型: News
42934335 Glimpsing archaeal microbes on the move. Nature 非研究性文章类型: News
42934334 The Selfish Gene, 50 years on - it's time for an update. Nature 非研究性文章类型: News
42919958 First person infected with rare Shamonda virus: what we know. Nature 非研究性文章类型: News
42919957 Moderna mRNA vaccine almost halves the risk of skin cancer returning. Nature 非研究性文章类型: News
42918909 Can maths survive AI? Fields medallist Terence Tao calls for a 'Maths 2.0' world. Nature 非研究性文章类型: News
42918875 A first for CRISPR: powerful prime editing alters DNA directly in the human body. Nature 非研究性文章类型: News
42918874 Can a 'lullaby' save coral reefs from extinction? Nature 非研究性文章类型: News
42918873 AI doctors' orders come with a sky-high bill. Nature 非研究性文章类型: News
42912169 The cognitive power of the avian brain. Science (New York, N.Y.) 非研究性文章类型: Journal Article, Comment
42912166 A cell death ballet in two acts. Science (New York, N.Y.) 非研究性文章类型: Journal Article, Comment
42912160 How the domestication of a killer bacterium led to Botox. Science (New York, N.Y.) 非研究性文章类型: News
42912141 The AI debate is missing half the system. Science (New York, N.Y.) 非研究性文章类型: Editorial
42907554 Teen depression and anxiety predicted by childhood brain development. Nature 非研究性文章类型: News
42907550 Huge mapping study reveals how your brain tracks what your body is feeling. Nature 非研究性文章类型: News
42907542 An AI tool improves weather forecasts up to a month ahead. Nature 非研究性文章类型: News
42907539 Worms live longer in cool conditions thanks to a muscle-derived molecule. Nature 非研究性文章类型: News
42907519 How tech billionaires are disrupting biomedical science. Nature 非研究性文章类型: News
42906539 Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell 非研究性文章类型: Published Erratum
42901967 Will this sleep-disorder drug be the next big blockbuster? Nature 非研究性文章类型: News
42901966 Conservation planning should follow animal clocks. Nature 非研究性文章类型: News
42901963 Nobel-prizewinning breakthroughs can emerge from neglected organisms. Nature 非研究性文章类型: News
42897299 Three reasons why AI is not conscious and perhaps never will be. Nature 非研究性文章类型: News
42897282 Microdosing LSD shows some cognitive benefits - but only for women. Nature 非研究性文章类型: News
42897279 Audio long read: How to stay smart in the age of AI - the science of critical thinking. Nature 非研究性文章类型: News
42897275 Memory stays strong in old age when this brain enzyme is active. Nature 非研究性文章类型: News
42888228 Briefing Chat: An invisible tattoo that appears under UV light - and then disappears. Nature 非研究性文章类型: News
42888227 Unprecedented atlas explores mitochondria across the tree of life. Nature 非研究性文章类型: News
42888226 PhD students who write dissertations with AI less likely to stay in academia. Nature 非研究性文章类型: News
... ... ... 共 184 篇，此处仅列出前 50 篇

最终质量检查

仅包含 Nature、Science、Cell 三本主刊

本报告由自动化流程生成，精选文献的中文翻译、摘要解读与趋势分析部分已由 AI 填充并复核。注：PubMed 部分记录未提供具体发表日，报告以 DOI 与官方链接为准；本月报告已剔除 8 篇与生物医学/AI（生物医学相关）无关的主刊文章（材料、化学、气候、能源类）。