本地 Zotero 文献库中含荧光共定位实验的文献清单
检索方式：Zotero 全文检索 colocalization + co-localization + 荧光共定位（everything 模式）检索时间：2026-07-21共检出 60 篇唯一文献（去重后）
一、神经退行性疾病（阿尔茨海默病/帕金森病）
| # |
文献题目 |
期刊 |
年份 |
| 1 |
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease |
Acta Neuropathologica |
2021 |
| 2 |
Complement and microglia mediate early synapse loss in Alzheimer mouse models |
Science |
2016 |
| 3 |
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease |
The FASEB Journal |
2012 |
| 4 |
Neuronal activity enhances tau propagation and tau pathology in vivo |
Nature Neuroscience |
2016 |
| 5 |
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model |
Nature Communications |
2019 |
| 6 |
Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease |
Journal of Neuroinflammation |
2022 |
| 7 |
Neuroinflammation in Alzheimer's disease |
The Lancet Neurology |
2015 |
| 8 |
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease |
Nature |
2020 |
| 9 |
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region |
EMBO Molecular Medicine |
2020 |
| 10 |
Structural and functional characterization of two alpha-synuclein strains |
Nature Communications |
2013 |
| 11 |
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration |
Nature Communications |
2020 |
二、血脑屏障与抗体转运
| # |
文献题目 |
期刊 |
年份 |
| 12 |
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants |
Journal of Experimental Medicine |
2014 |
| 13 |
Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle |
Neuron |
2014 |
| 14 |
The blood-brain barrier: Physiology and strategies for drug delivery |
Advanced Drug Delivery Reviews |
2020 |
三、酪氨酸硫酸化（sY）
| # |
文献题目 |
期刊 |
年份 |
| 15 |
Electron Capture vs Transfer Dissociation for Site Determination of Tryptic Peptide Tyrosine Sulfation |
Journal of Proteome Research |
2024 |
| 16 |
Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig |
EBioMedicine |
2018 |
| 17 |
Neuroprotective response against the onset of ischemic stroke by upregulation of histone H3Y99 sulfation |
Cell Reports Medicine |
2026 |
| 18 |
GAL3ST1-Mediated Histone Tyrosine Sulfation Induced by Cancer-Associated Fibroblasts Promotes Gastric Cancer Metastasis |
Cancer Research |
2026 |
| 19 |
Determination of the sites of tyrosine O-sulfation in peptides and proteins |
Nature Methods |
2007 |
| 20 |
Specific recognition mechanism of an antibody to sulfated tyrosine and its potential use in biological research |
Journal of Biological Chemistry |
2025 |
| 21 |
Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors |
RSC Advances |
2019 |
| 22 |
Development of a Sample-Preparation Workflow for Sulfopeptide Enrichment |
Analytical Chemistry |
2020 |
| 23 |
Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition |
PNAS |
2020 |
| 24 |
Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display |
JACS |
2020 |
| 25 |
Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects antibody recognition |
PLOS ONE |
2021 |
| 26 |
Using circulating O-sulfotyrosine in the differential diagnosis of acute kidney injury and chronic kidney disease |
BMC Nephrology |
2021 |
| 27 |
Tyrosylprotein sulfotransferase-dependent and -independent regulation of root development and signaling by PSK LRR receptor kinases in Arabidopsis |
Journal of Experimental Botany |
2021 |
四、选择素-PSGL-1 相互作用（含硫酸化）
| # |
文献题目 |
期刊 |
年份 |
| 28 |
A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding |
Cell |
1995 |
| 29 |
Insights into the Molecular Basis of Leukocyte Tethering and Rolling Revealed by Structures of P- and E-Selectin Bound to SLeX and PSGL-1 |
Cell |
2000 |
| 30 |
Recognition of a CXCR4 Sulfotyrosine by the Chemokine Stromal Cell-derived Factor-1α (SDF-1α/CXCL12) |
Journal of Molecular Biology |
2006 |
| 31 |
Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120 |
PNAS |
2000 |
五、HIV/病毒中和抗体
| # |
文献题目 |
期刊 |
年份 |
| 32 |
Asymmetric opening of HIV-1 Env bound to CD4 and a coreceptor-mimicking antibody |
Nature Structural & Molecular Biology |
2019 |
| 33 |
Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope |
Cell Reports |
2020 |
| 34 |
Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site |
BMC Biology |
2020 |
| 35 |
A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies |
Journal of Virology |
2019 |
| 36 |
In vitro affinity maturation of broader and more-potent variants of the HIV-1–neutralizing antibody CAP256-VRC26.25 |
PNAS |
2021 |
| 37 |
Monkeypox virus protein OPG188 antagonizes cGAS–STING antiviral signaling pathway to mediate immune evasion |
PNAS |
2026 |
六、纳米抗体与小型蛋白支架
| # |
文献题目 |
期刊 |
年份 |
| 38 |
Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1 |
Life Science Alliance |
2024 |
| 39 |
Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies |
Chemical Science |
2018 |
| 40 |
Actin chromobody imaging reveals sub-organellar actin dynamics |
Nature Methods |
2020 |
| 41 |
Destabilized near-infrared fluorescent nanobodies enable background-free targeting of GFP-based biosensors |
Nature Communications |
2024 |
| 42 |
Development of a V5-tag–directed nanobody and its implementation as an intracellular biosensor of GPCR signaling |
Journal of Biological Chemistry |
2023 |
| 43 |
Therapeutic antibodies: successes, limitations and hopes for the future |
British Journal of Pharmacology |
2009 |
| 44 |
Alternative non-antibody scaffolds for molecular recognition |
Current Opinion in Biotechnology |
2007 |
| 45 |
High-affinity single-domain binding proteins with a binary-code interface |
PNAS |
2007 |
| 46 |
Engineering of binding functions into proteins |
Current Opinion in Biotechnology |
2019 |
| 47 |
Engineered Protein Scaffolds as Next-Generation Therapeutics |
Annual Review of Pharmacology and Toxicology |
2020 |
七、赖氨酸甲基化 / 表观遗传
| # |
文献题目 |
期刊 |
年份 |
| 48 |
Regulation of gene transcription by Polycomb proteins |
Science Advances |
2015 |
| 49 |
Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin |
Molecular Cell |
2003 |
| 50 |
Protein methylome analysis in Arabidopsis reveals regulation in RNA-related processes |
Journal of Proteomics |
2020 |
| 51 |
蛋白质甲基化修饰的蛋白质组学分析方法新进展 |
— |
— |
| 52 |
Integrated proteomic analysis of post-translational modifications by serial enrichment |
Nature Methods |
2013 |
八、其他
| # |
文献题目 |
期刊 |
年份 |
| 53 |
Immunolabeling artifacts and the need for live-cell imaging |
Nature Methods |
2012 |
| 54 |
SH2 and SH3 domains: From structure to function |
Cell |
1992 |
| 55 |
A Simple Cipher Governs DNA Recognition by TAL Effectors |
Science |
2009 |
| 56 |
The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation |
Annual Review of Biochemistry |
2010 |
| 57 |
Neuroprotective Peptide NAPVSIPQ Antagonizes Ethanol Inhibition of L1 Adhesion |
Biological Psychiatry |
2020 |
| 58 |
Regulation of plant peptide hormones and growth factors by post‐translational modification |
Plant Biology |
2019 |
| 59 |
Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade |
Science |
2024 |
| 60 |
Synergistic Combination of Oral Transcytotic Nanomedicine and Histone Demethylase Inhibitor for Enhanced Cancer Chemoimmunotherapy |
ACS Nano |
2024 |
注：本清单基于 Zotero 全文检索结果，检索词为 colocalization / co-localization / 荧光共定位。文献按研究方向分类排列。部分文献中"荧光共定位"可能仅在方法部分提及，具体实验内容需查阅原文确认。